1.8.4.10: adenylyl-sulfate reductase (thioredoxin)

This is an abbreviated version!
For detailed information about adenylyl-sulfate reductase (thioredoxin), go to the full flat file.

Word Map on EC 1.8.4.10

Reaction

AMP
+
sulfite
+
thioredoxin disulfide
=
5'-adenylyl sulfate
+
thioredoxin

Synonyms

5'-adenylylsulfate reductase, adenosine-5'-phosphosulfate reductase, adenylylsulfate reductase, APR, APR-B, APS reductase, PaAPR, PpAPR-B, thioredoxin dependent 5'-adenylylsulfate reductase, thioredoxin-dependent APS reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.10 adenylyl-sulfate reductase (thioredoxin)

Engineering

Engineering on EC 1.8.4.10 - adenylyl-sulfate reductase (thioredoxin)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D122G
mutant does not display improved activity with 3'-phosphoadenosine-5'-phosphosulfate and shows significantly reduced activity with 5'-adenylylsulfate as the substrate
C139S
-
no activity
C140S
-
mutant enzyme shows 3% of wild-type activity
C228S
-
no activity
C231S
-
no activity
C256S
-
no activity
additional information