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EC 2.7.7.72 Details
show Brenda entryEC number
2.7.7.72
Accepted name
CCA tRNA nucleotidyltransferase
Reaction
a tRNA precursor + 2 CTP + ATP = a tRNA with a 3′ CCA end + 3 diphosphate (overall reaction);;(1a) a tRNA precursor + CTP = a tRNA with a 3′ cytidine end + diphosphate;;(1b) a tRNA with a 3′ cytidine + CTP = a tRNA with a 3′ CC end + diphosphate;;(1c) a tRNA with a 3′ CC end + ATP = a tRNA with a 3′ CCA end + diphosphate
Other name(s)
CCA-adding enzyme,
tRNA adenylyltransferase,
tRNA cytidylyltransferase,
tRNA CCA-pyrophosphorylase,
tRNA-nucleotidyltransferase,
transfer-RNA nucleotidyltransferase,
transfer ribonucleic acid nucleotidyl transferase,
CTP(ATP):tRNA nucleotidyltransferase,
transfer ribonucleate adenylyltransferase,
transfer ribonucleate adenyltransferase,
transfer RNA adenylyltransferase,
transfer ribonucleate nucleotidyltransferase,
ATP (CTP):tRNA nucleotidyltransferase,
ribonucleic cytidylic cytidylic adenylic pyrophosphorylase,
transfer ribonucleic adenylyl (cytidylyl) transferase,
transfer ribonucleic-terminal trinucleotide nucleotidyltransferase,
transfer ribonucleate cytidylyltransferase,
ribonucleic cytidylyltransferase,
-C-C-A pyrophosphorylase,
ATP(CTP)-tRNA nucleotidyltransferase,
tRNA adenylyl(cytidylyl)transferase,
CTP:tRNA cytidylyltransferase
Systematic name
CTP,CTP,ATP:tRNA cytidylyl,cytidylyl,adenylyltransferase
Comment
The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3′ CCA sequence. The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition [5].
History
created 1965 as EC 2.7.7.21 and EC 2.7.7.25, both transferred 2010 to EC 2.7.7.72
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1 Oxidoreductases
2 Transferases
2.7.7.20 created 1965, deleted 1972 2.7.7.29 created 1972, deleted 2004
