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EC 2.7.11.15 Details

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EC number

2.7.11.15

Accepted name

β-adrenergic-receptor kinase

Reaction

ATP + [β-adrenergic receptor] = ADP + phospho-[β-adrenergic receptor]

Other name(s)

ATP:β-adrenergic-receptor phosphotransferase, [β-adrenergic-receptor] kinase, β-adrenergic receptor-specific kinase, β-AR kinase, β-ARK, β-ARK 1, β-ARK 2, β-receptor kinase, GRK2, GRK3, β-adrenergic-receptor kinase (phosphorylating), β2ARK, βARK1, β-adrenoceptor kinase, β-adrenoceptor kinase 1, β-adrenoceptor kinase 2, ADRBK1, BARK1, adrenergic receptor kinase, STK15

Systematic name

ATP:[β-adrenergic receptor] phosphotransferase

CAS registry number

102925-39-3

Comment

Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn²⁺ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).

History

created 1989 as EC 2.7.1.126, transferred 2005 to EC 2.7.11.15

EC Tree

1 Oxidoreductases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.2 Phosphotransferases with a carboxy group as acceptor

2.7.3 Phosphotransferases with a nitrogenous group as acceptor

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)

2.7.6 Diphosphotransferases

2.7.7 Nucleotidyltransferases

2.7.7.1 nicotinamide-nucleotide adenylyltransferase

2.7.7.2 FAD synthase

2.7.7.3 pantetheine-phosphate adenylyltransferase

2.7.7.4 sulfate adenylyltransferase

2.7.7.5 sulfate adenylyltransferase (ADP)

2.7.7.6 DNA-directed RNA polymerase

2.7.7.7 DNA-directed DNA polymerase

2.7.7.8 polyribonucleotide nucleotidyltransferase

2.7.7.9 UTP—glucose-1-phosphate uridylyltransferase

2.7.7.10 UTP—hexose-1-phosphate uridylyltransferase

2.7.7.11 UTP—xylose-1-phosphate uridylyltransferase

2.7.7.12 UDP-glucose—hexose-1-phosphate uridylyltransferase

2.7.7.13 mannose-1-phosphate guanylyltransferase

2.7.7.14 ethanolamine-phosphate cytidylyltransferase

2.7.7.15 choline-phosphate cytidylyltransferase

2.7.7.16 created 1961, deleted 1972, [transferred to EC 3.1.4.22, deleted 1980]

2.7.7.17 created 1965, deleted 1972, [transferred to EC 3.1.4.23, deleted 1980]

2.7.7.18 nicotinate-nucleotide adenylyltransferase

2.7.7.19 polynucleotide adenylyltransferase

2.7.7.20 created 1965, deleted 1972

2.7.7.21 tRNA cytidylyltransferase

2.7.7.22 mannose-1-phosphate guanylyltransferase (GDP)

2.7.7.23 UDP-N-acetylglucosamine diphosphorylase

2.7.7.24 glucose-1-phosphate thymidylyltransferase

2.7.7.25 tRNA adenylyltransferase

2.7.7.26 created 1961 as EC 3.1.4.8, transferred 1965 to EC 2.7.7.26, deleted 1972

2.7.7.27 glucose-1-phosphate adenylyltransferase

2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase

2.7.7.29 created 1972, deleted 2004

2.7.7.30 fucose-1-phosphate guanylyltransferase

2.7.7.31 DNA nucleotidylexotransferase

2.7.7.32 galactose-1-phosphate thymidylyltransferase

2.7.7.33 glucose-1-phosphate cytidylyltransferase

2.7.7.34 glucose-1-phosphate guanylyltransferase

2.7.7.35 ADP ribose phosphorylase

2.7.7.36 aldose-1-phosphate adenylyltransferase

2.7.7.37 aldose-1-phosphate nucleotidyltransferase

2.7.7.38 3-deoxy-manno-octulosonate cytidylyltransferase

2.7.7.39 glycerol-3-phosphate cytidylyltransferase

2.7.7.40 D-ribitol-5-phosphate cytidylyltransferase

2.7.7.41 phosphatidate cytidylyltransferase

2.7.7.42 [glutamine synthetase] adenylyltransferase

2.7.7.43 N-acylneuraminate cytidylyltransferase

2.7.7.44 glucuronate-1-phosphate uridylyltransferase

2.7.7.45 guanosine-triphosphate guanylyltransferase

2.7.7.46 gentamicin 2′′-nucleotidyltransferase

2.7.7.47 streptomycin 3′′-adenylyltransferase

2.7.7.48 RNA-directed RNA polymerase

2.7.7.49 RNA-directed DNA polymerase

2.7.7.50 mRNA guanylyltransferase

2.7.7.51 adenylylsulfate—ammonia adenylyltransferase

2.7.7.52 RNA uridylyltransferase

2.7.7.53 ATP adenylyltransferase

2.7.7.54 phenylalanine adenylyltransferase

2.7.7.55 anthranilate adenylyltransferase

2.7.7.56 tRNA nucleotidyltransferase

2.7.7.57 N-methylphosphoethanolamine cytidylyltransferase

2.7.7.58 (2,3-dihydroxybenzoyl)adenylate synthase

2.7.7.59 [protein-PII] uridylyltransferase

2.7.7.60 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

2.7.7.61 citrate lyase holo-[acyl-carrier protein] synthase

2.7.7.62 adenosylcobinamide-phosphate guanylyltransferase

2.7.7.63 lipoate—protein ligase

2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase

2.7.7.65 diguanylate cyclase

2.7.7.66 malonate decarboxylase holo-[acyl-carrier protein] synthase

2.7.7.67 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase

2.7.7.68 2-phospho-L-lactate guanylyltransferase

2.7.7.69 GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase

2.7.7.70 D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase

2.7.7.71 D-glycero-α-D-manno-heptose 1-phosphate guanylyltransferase

2.7.7.72 CCA tRNA nucleotidyltransferase

2.7.7.73 sulfur carrier protein ThiS adenylyltransferase

2.7.7.74 1L-myo-inositol 1-phosphate cytidylyltransferase

2.7.7.75 molybdopterin adenylyltransferase

2.7.7.76 molybdenum cofactor cytidylyltransferase

2.7.7.77 molybdenum cofactor guanylyltransferase

2.7.7.78 GDP-D-glucose phosphorylase

2.7.7.79 tRNA^His guanylyltransferase

2.7.7.80 molybdopterin-synthase adenylyltransferase

2.7.7.81 pseudaminic acid cytidylyltransferase

2.7.7.82 CMP-N,N′-diacetyllegionaminic acid synthase

2.7.7.83 UDP-N-acetylgalactosamine diphosphorylase

2.7.7.84 2′-5′ oligoadenylate synthase

2.7.7.85 diadenylate cyclase

2.7.7.86 cyclic GMP-AMP synthase

2.7.7.87 L-threonylcarbamoyladenylate synthase

2.7.7.88 GDP polyribonucleotidyltransferase

2.7.7.89 [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase

2.7.7.90 8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase

2.7.7.91 valienol-1-phosphate guanylyltransferase

2.7.7.92 3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase

2.7.7.93 phosphonoformate cytidylyltransferase

2.7.7.94 4-hydroxyphenylalkanoate adenylyltransferase

2.7.7.95 mycocerosic acid adenylyltransferase

2.7.7.96 ADP-D-ribose pyrophosphorylase

2.7.7.97 3-hydroxy-4-methylanthranilate adenylyltransferase

2.7.7.98 4-hydroxybenzoate adenylyltransferase

2.7.7.99 N-acetyl-α-D-muramate 1-phosphate uridylyltransferase

2.7.7.100 SAMP-activating enzyme

2.7.7.101 DNA primase DnaG

2.7.7.102 DNA primase AEP

2.7.7.103 L-glutamine-phosphate cytidylyltransferase

2.7.7.104 2-hydroxyethylphosphonate cytidylyltransferase

2.7.7.105 phosphoenolpyruvate guanylyltransferase

2.7.7.106 3-phospho-D-glycerate guanylyltransferase

2.7.7.107 (2-aminoethyl)phosphonate cytidylyltransferase

2.7.7.108 protein adenylyltransferase

2.7.8 Transferases for other substituted phosphate groups

2.7.9 Phosphotransferases with paired acceptors

2.7.10 Protein-tyrosine kinases

2.7.11 Protein-serine/threonine kinases

2.7.11.1 non-specific serine/threonine protein kinase

2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase

2.7.11.3 dephospho-[reductase kinase] kinase

2.7.11.4 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase

2.7.11.5 [isocitrate dehydrogenase (NADP⁺)] kinase

2.7.11.6 [tyrosine 3-monooxygenase] kinase

2.7.11.7 myosin-heavy-chain kinase

2.7.11.8 Fas-activated serine/threonine kinase

2.7.11.9 Goodpasture-antigen-binding protein kinase

2.7.11.10 IκB kinase

2.7.11.11 cAMP-dependent protein kinase

2.7.11.12 cGMP-dependent protein kinase

2.7.11.13 protein kinase C

2.7.11.14 rhodopsin kinase

2.7.11.15 β-adrenergic-receptor kinase

2.7.11.16 G-protein-coupled receptor kinase

2.7.11.17 Ca²⁺/calmodulin-dependent protein kinase

2.7.11.18 myosin-light-chain kinase

2.7.11.19 phosphorylase kinase

2.7.11.20 elongation factor 2 kinase

2.7.11.21 polo kinase

2.7.11.22 cyclin-dependent kinase

2.7.11.23 [RNA-polymerase]-subunit kinase

2.7.11.24 mitogen-activated protein kinase

2.7.11.25 mitogen-activated protein kinase kinase kinase

2.7.11.26 tau-protein kinase

2.7.11.27 [acetyl-CoA carboxylase] kinase

2.7.11.28 tropomyosin kinase

2.7.11.29 low-density-lipoprotein receptor kinase

2.7.11.30 receptor protein serine/threonine kinase

2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase

2.7.11.32 [pyruvate, phosphate dikinase] kinase

2.7.11.33 [pyruvate, water dikinase] kinase

2.7.11.34 NEK6-subfamily protein kinase

2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)

2.7.13 Protein-histidine kinases

2.7.14 Protein-arginine kinases

2.7.99 Other protein kinases

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

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Release 2023.1 (January 2023)