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EC 2.7.11.31 Details
EC number
2.7.11.31
Accepted name
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
Reaction
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
Other name(s)
AMPK, AMP-activated protein kinase, HMG-CoA reductase kinase, β-hydroxy-β-methylglutaryl-CoA reductase kinase, [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase, 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase, 3-hydroxy-3-methylglutaryl-CoA reductase kinase, hydroxymethylglutaryl coenzyme A reductase kinase, hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating), hydroxymethylglutaryl-CoA reductase kinase, reductase kinase, STK29
Systematic name
ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase
CAS registry number
172522-01-9
Comment
The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79) [5]. Thr-172 within the catalytic subunit (α-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase [7]. GTP can act instead of ATP [4]
History
created 1984 as EC 2.7.1.109, transferred 2005 to EC 2.7.11.31
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EC Tree
1 Oxidoreductases
2 Transferases
2.1 Transferring one-carbon groups
2.2 Transferring aldehyde or ketonic groups
2.3 Acyltransferases
2.4 Glycosyltransferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.6 Transferring nitrogenous groups
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.3 Phosphotransferases with a nitrogenous group as acceptor
2.7.4 Phosphotransferases with a phosphate group as acceptor
2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)
2.7.6 Diphosphotransferases
2.7.7 Nucleotidyltransferases
2.7.7.1 nicotinamide-nucleotide adenylyltransferase
2.7.7.2 FAD synthase
2.7.7.3 pantetheine-phosphate adenylyltransferase
2.7.7.4 sulfate adenylyltransferase
2.7.7.5 sulfate adenylyltransferase (ADP)
2.7.7.6 DNA-directed RNA polymerase
2.7.7.7 DNA-directed DNA polymerase
2.7.7.8 polyribonucleotide nucleotidyltransferase
2.7.7.9 UTP—glucose-1-phosphate uridylyltransferase
2.7.7.10 UTP—hexose-1-phosphate uridylyltransferase
2.7.7.11 UTP—xylose-1-phosphate uridylyltransferase
2.7.7.12 UDP-glucose—hexose-1-phosphate uridylyltransferase
2.7.7.13 mannose-1-phosphate guanylyltransferase
2.7.7.14 ethanolamine-phosphate cytidylyltransferase
2.7.7.15 choline-phosphate cytidylyltransferase
2.7.7.16 created 1961, deleted 1972, [transferred to EC 3.1.4.22, deleted 1980]
2.7.7.17 created 1965, deleted 1972, [transferred to EC 3.1.4.23, deleted 1980]
2.7.7.18 nicotinate-nucleotide adenylyltransferase
2.7.7.19 polynucleotide adenylyltransferase
2.7.7.20 created 1965, deleted 1972
2.7.7.21 tRNA cytidylyltransferase
2.7.7.22 mannose-1-phosphate guanylyltransferase (GDP)
2.7.7.23 UDP-N-acetylglucosamine diphosphorylase
2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.25 tRNA adenylyltransferase
2.7.7.26 created 1961 as EC 3.1.4.8, transferred 1965 to EC 2.7.7.26, deleted 1972
2.7.7.27 glucose-1-phosphate adenylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.29 created 1972, deleted 2004
2.7.7.30 fucose-1-phosphate guanylyltransferase
2.7.7.31 DNA nucleotidylexotransferase
2.7.7.32 galactose-1-phosphate thymidylyltransferase
2.7.7.33 glucose-1-phosphate cytidylyltransferase
2.7.7.34 glucose-1-phosphate guanylyltransferase
2.7.7.35 ADP ribose phosphorylase
2.7.7.36 aldose-1-phosphate adenylyltransferase
2.7.7.37 aldose-1-phosphate nucleotidyltransferase
2.7.7.38 3-deoxy-manno-octulosonate cytidylyltransferase
2.7.7.39 glycerol-3-phosphate cytidylyltransferase
2.7.7.40 D-ribitol-5-phosphate cytidylyltransferase
2.7.7.41 phosphatidate cytidylyltransferase
2.7.7.42 [glutamine synthetase] adenylyltransferase
2.7.7.43 N-acylneuraminate cytidylyltransferase
2.7.7.44 glucuronate-1-phosphate uridylyltransferase
2.7.7.45 guanosine-triphosphate guanylyltransferase
2.7.7.46 gentamicin 2′′-nucleotidyltransferase
2.7.7.47 streptomycin 3′′-adenylyltransferase
2.7.7.48 RNA-directed RNA polymerase
2.7.7.49 RNA-directed DNA polymerase
2.7.7.50 mRNA guanylyltransferase
2.7.7.51 adenylylsulfate—ammonia adenylyltransferase
2.7.7.52 RNA uridylyltransferase
2.7.7.53 ATP adenylyltransferase
2.7.7.54 phenylalanine adenylyltransferase
2.7.7.55 anthranilate adenylyltransferase
2.7.7.56 tRNA nucleotidyltransferase
2.7.7.57 N-methylphosphoethanolamine cytidylyltransferase
2.7.7.58 (2,3-dihydroxybenzoyl)adenylate synthase
2.7.7.59 [protein-PII] uridylyltransferase
2.7.7.60 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
2.7.7.61 citrate lyase holo-[acyl-carrier protein] synthase
2.7.7.62 adenosylcobinamide-phosphate guanylyltransferase
2.7.7.63 lipoate—protein ligase
2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase
2.7.7.65 diguanylate cyclase
2.7.7.66 malonate decarboxylase holo-[acyl-carrier protein] synthase
2.7.7.67 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
2.7.7.68 2-phospho-L-lactate guanylyltransferase
2.7.7.69 GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase
2.7.7.70 D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase
2.7.7.71 D-glycero-α-D-manno-heptose 1-phosphate guanylyltransferase
2.7.7.72 CCA tRNA nucleotidyltransferase
2.7.7.73 sulfur carrier protein ThiS adenylyltransferase
2.7.7.74 1L-myo-inositol 1-phosphate cytidylyltransferase
2.7.7.75 molybdopterin adenylyltransferase
2.7.7.76 molybdenum cofactor cytidylyltransferase
2.7.7.77 molybdenum cofactor guanylyltransferase
2.7.7.78 GDP-D-glucose phosphorylase
2.7.7.79 tRNAHis guanylyltransferase
2.7.7.80 molybdopterin-synthase adenylyltransferase
2.7.7.81 pseudaminic acid cytidylyltransferase
2.7.7.82 CMP-N,N′-diacetyllegionaminic acid synthase
2.7.7.83 UDP-N-acetylgalactosamine diphosphorylase
2.7.7.84 2′-5′ oligoadenylate synthase
2.7.7.85 diadenylate cyclase
2.7.7.86 cyclic GMP-AMP synthase
2.7.7.87 L-threonylcarbamoyladenylate synthase
2.7.7.88 GDP polyribonucleotidyltransferase
2.7.7.89 [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
2.7.7.90 8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase
2.7.7.91 valienol-1-phosphate guanylyltransferase
2.7.7.92 3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase
2.7.7.93 phosphonoformate cytidylyltransferase
2.7.7.94 4-hydroxyphenylalkanoate adenylyltransferase
2.7.7.95 mycocerosic acid adenylyltransferase
2.7.7.96 ADP-D-ribose pyrophosphorylase
2.7.7.97 3-hydroxy-4-methylanthranilate adenylyltransferase
2.7.7.98 4-hydroxybenzoate adenylyltransferase
2.7.7.99 N-acetyl-α-D-muramate 1-phosphate uridylyltransferase
2.7.7.100 SAMP-activating enzyme
2.7.7.101 DNA primase DnaG
2.7.7.102 DNA primase AEP
2.7.7.103 L-glutamine-phosphate cytidylyltransferase
2.7.7.104 2-hydroxyethylphosphonate cytidylyltransferase
2.7.7.105 phosphoenolpyruvate guanylyltransferase
2.7.7.106 3-phospho-D-glycerate guanylyltransferase
2.7.7.107 (2-aminoethyl)phosphonate cytidylyltransferase
2.7.7.108 protein adenylyltransferase
2.7.8 Transferases for other substituted phosphate groups
2.7.9 Phosphotransferases with paired acceptors
2.7.10 Protein-tyrosine kinases
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase
2.7.11.3 dephospho-[reductase kinase] kinase
2.7.11.4 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
2.7.11.5 [isocitrate dehydrogenase (NADP+)] kinase
2.7.11.6 [tyrosine 3-monooxygenase] kinase
2.7.11.7 myosin-heavy-chain kinase
2.7.11.8 Fas-activated serine/threonine kinase
2.7.11.9 Goodpasture-antigen-binding protein kinase
2.7.11.10 IκB kinase
2.7.11.11 cAMP-dependent protein kinase
2.7.11.12 cGMP-dependent protein kinase
2.7.11.13 protein kinase C
2.7.11.14 rhodopsin kinase
2.7.11.15 β-adrenergic-receptor kinase
2.7.11.16 G-protein-coupled receptor kinase
2.7.11.17 Ca2+/calmodulin-dependent protein kinase
2.7.11.18 myosin-light-chain kinase
2.7.11.19 phosphorylase kinase
2.7.11.20 elongation factor 2 kinase
2.7.11.21 polo kinase
2.7.11.22 cyclin-dependent kinase
2.7.11.23 [RNA-polymerase]-subunit kinase
2.7.11.24 mitogen-activated protein kinase
2.7.11.25 mitogen-activated protein kinase kinase kinase
2.7.11.26 tau-protein kinase
2.7.11.27 [acetyl-CoA carboxylase] kinase
2.7.11.28 tropomyosin kinase
2.7.11.29 low-density-lipoprotein receptor kinase
2.7.11.30 receptor protein serine/threonine kinase
2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
2.7.11.32 [pyruvate, phosphate dikinase] kinase
2.7.11.33 [pyruvate, water dikinase] kinase
2.7.11.34 NEK6-subfamily protein kinase
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.13 Protein-histidine kinases
2.7.14 Protein-arginine kinases
2.7.99 Other protein kinases
2.8 Transferring sulfur-containing groups
2.9 Transferring selenium-containing groups
2.10 Transferring molybdenum- or tungsten-containing groups
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
7 Translocases