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EC 2.7.7.93 Details

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EC number

2.7.7.93

Accepted name

phosphonoformate cytidylyltransferase

Reaction

CTP + phosphonoformate = CMP-5′-phosphonoformate + diphosphate

Other name(s)

phpF (gene name)

Systematic name

CTP:phosphonoformate cytidylyltransferase

Comment

The enzyme, characterized from the bacterium Streptomyces viridochromogenes, participates in the biosynthesis of the herbicide antibiotic bialaphos. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase.

History

created 2016

EC Tree

1 Oxidoreductases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.2 Phosphotransferases with a carboxy group as acceptor

2.7.3 Phosphotransferases with a nitrogenous group as acceptor

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)

2.7.6 Diphosphotransferases

2.7.7 Nucleotidyltransferases

2.7.7.1 nicotinamide-nucleotide adenylyltransferase

2.7.7.2 FAD synthase

2.7.7.3 pantetheine-phosphate adenylyltransferase

2.7.7.4 sulfate adenylyltransferase

2.7.7.5 sulfate adenylyltransferase (ADP)

2.7.7.6 DNA-directed RNA polymerase

2.7.7.7 DNA-directed DNA polymerase

2.7.7.8 polyribonucleotide nucleotidyltransferase

2.7.7.9 UTP—glucose-1-phosphate uridylyltransferase

2.7.7.10 UTP—hexose-1-phosphate uridylyltransferase

2.7.7.11 UTP—xylose-1-phosphate uridylyltransferase

2.7.7.12 UDP-glucose—hexose-1-phosphate uridylyltransferase

2.7.7.13 mannose-1-phosphate guanylyltransferase

2.7.7.14 ethanolamine-phosphate cytidylyltransferase

2.7.7.15 choline-phosphate cytidylyltransferase

2.7.7.16 created 1961, deleted 1972, [transferred to EC 3.1.4.22, deleted 1980]

2.7.7.17 created 1965, deleted 1972, [transferred to EC 3.1.4.23, deleted 1980]

2.7.7.18 nicotinate-nucleotide adenylyltransferase

2.7.7.19 polynucleotide adenylyltransferase

2.7.7.20 created 1965, deleted 1972

2.7.7.21 tRNA cytidylyltransferase

2.7.7.22 mannose-1-phosphate guanylyltransferase (GDP)

2.7.7.23 UDP-N-acetylglucosamine diphosphorylase

2.7.7.24 glucose-1-phosphate thymidylyltransferase

2.7.7.25 tRNA adenylyltransferase

2.7.7.26 created 1961 as EC 3.1.4.8, transferred 1965 to EC 2.7.7.26, deleted 1972

2.7.7.27 glucose-1-phosphate adenylyltransferase

2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase

2.7.7.29 created 1972, deleted 2004

2.7.7.30 fucose-1-phosphate guanylyltransferase

2.7.7.31 DNA nucleotidylexotransferase

2.7.7.32 galactose-1-phosphate thymidylyltransferase

2.7.7.33 glucose-1-phosphate cytidylyltransferase

2.7.7.34 glucose-1-phosphate guanylyltransferase

2.7.7.35 ADP ribose phosphorylase

2.7.7.36 aldose-1-phosphate adenylyltransferase

2.7.7.37 aldose-1-phosphate nucleotidyltransferase

2.7.7.38 3-deoxy-manno-octulosonate cytidylyltransferase

2.7.7.39 glycerol-3-phosphate cytidylyltransferase

2.7.7.40 D-ribitol-5-phosphate cytidylyltransferase

2.7.7.41 phosphatidate cytidylyltransferase

2.7.7.42 [glutamine synthetase] adenylyltransferase

2.7.7.43 N-acylneuraminate cytidylyltransferase

2.7.7.44 glucuronate-1-phosphate uridylyltransferase

2.7.7.45 guanosine-triphosphate guanylyltransferase

2.7.7.46 gentamicin 2′′-nucleotidyltransferase

2.7.7.47 streptomycin 3′′-adenylyltransferase

2.7.7.48 RNA-directed RNA polymerase

2.7.7.49 RNA-directed DNA polymerase

2.7.7.50 mRNA guanylyltransferase

2.7.7.51 adenylylsulfate—ammonia adenylyltransferase

2.7.7.52 RNA uridylyltransferase

2.7.7.53 ATP adenylyltransferase

2.7.7.54 phenylalanine adenylyltransferase

2.7.7.55 anthranilate adenylyltransferase

2.7.7.56 tRNA nucleotidyltransferase

2.7.7.57 N-methylphosphoethanolamine cytidylyltransferase

2.7.7.58 (2,3-dihydroxybenzoyl)adenylate synthase

2.7.7.59 [protein-PII] uridylyltransferase

2.7.7.60 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

2.7.7.61 citrate lyase holo-[acyl-carrier protein] synthase

2.7.7.62 adenosylcobinamide-phosphate guanylyltransferase

2.7.7.63 lipoate—protein ligase

2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase

2.7.7.65 diguanylate cyclase

2.7.7.66 malonate decarboxylase holo-[acyl-carrier protein] synthase

2.7.7.67 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase

2.7.7.68 2-phospho-L-lactate guanylyltransferase

2.7.7.69 GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase

2.7.7.70 D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase

2.7.7.71 D-glycero-α-D-manno-heptose 1-phosphate guanylyltransferase

2.7.7.72 CCA tRNA nucleotidyltransferase

2.7.7.73 sulfur carrier protein ThiS adenylyltransferase

2.7.7.74 1L-myo-inositol 1-phosphate cytidylyltransferase

2.7.7.75 molybdopterin adenylyltransferase

2.7.7.76 molybdenum cofactor cytidylyltransferase

2.7.7.77 molybdenum cofactor guanylyltransferase

2.7.7.78 GDP-D-glucose phosphorylase

2.7.7.79 tRNA^His guanylyltransferase

2.7.7.80 molybdopterin-synthase adenylyltransferase

2.7.7.81 pseudaminic acid cytidylyltransferase

2.7.7.82 CMP-N,N′-diacetyllegionaminic acid synthase

2.7.7.83 UDP-N-acetylgalactosamine diphosphorylase

2.7.7.84 2′-5′ oligoadenylate synthase

2.7.7.85 diadenylate cyclase

2.7.7.86 cyclic GMP-AMP synthase

2.7.7.87 L-threonylcarbamoyladenylate synthase

2.7.7.88 GDP polyribonucleotidyltransferase

2.7.7.89 [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase

2.7.7.90 8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase

2.7.7.91 valienol-1-phosphate guanylyltransferase

2.7.7.92 3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase

2.7.7.93 phosphonoformate cytidylyltransferase

2.7.7.94 4-hydroxyphenylalkanoate adenylyltransferase

2.7.7.95 mycocerosic acid adenylyltransferase

2.7.7.96 ADP-D-ribose pyrophosphorylase

2.7.7.97 3-hydroxy-4-methylanthranilate adenylyltransferase

2.7.7.98 4-hydroxybenzoate adenylyltransferase

2.7.7.99 N-acetyl-α-D-muramate 1-phosphate uridylyltransferase

2.7.7.100 SAMP-activating enzyme

2.7.7.101 DNA primase DnaG

2.7.7.102 DNA primase AEP

2.7.7.103 L-glutamine-phosphate cytidylyltransferase

2.7.7.104 2-hydroxyethylphosphonate cytidylyltransferase

2.7.7.105 phosphoenolpyruvate guanylyltransferase

2.7.7.106 3-phospho-D-glycerate guanylyltransferase

2.7.7.107 (2-aminoethyl)phosphonate cytidylyltransferase

2.7.7.108 protein adenylyltransferase

2.7.8 Transferases for other substituted phosphate groups

2.7.9 Phosphotransferases with paired acceptors

2.7.10 Protein-tyrosine kinases

2.7.11 Protein-serine/threonine kinases

2.7.11.1 non-specific serine/threonine protein kinase

2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase

2.7.11.3 dephospho-[reductase kinase] kinase

2.7.11.4 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase

2.7.11.5 [isocitrate dehydrogenase (NADP⁺)] kinase

2.7.11.6 [tyrosine 3-monooxygenase] kinase

2.7.11.7 myosin-heavy-chain kinase

2.7.11.8 Fas-activated serine/threonine kinase

2.7.11.9 Goodpasture-antigen-binding protein kinase

2.7.11.10 IκB kinase

2.7.11.11 cAMP-dependent protein kinase

2.7.11.12 cGMP-dependent protein kinase

2.7.11.13 protein kinase C

2.7.11.14 rhodopsin kinase

2.7.11.15 β-adrenergic-receptor kinase

2.7.11.16 G-protein-coupled receptor kinase

2.7.11.17 Ca²⁺/calmodulin-dependent protein kinase

2.7.11.18 myosin-light-chain kinase

2.7.11.19 phosphorylase kinase

2.7.11.20 elongation factor 2 kinase

2.7.11.21 polo kinase

2.7.11.22 cyclin-dependent kinase

2.7.11.23 [RNA-polymerase]-subunit kinase

2.7.11.24 mitogen-activated protein kinase

2.7.11.25 mitogen-activated protein kinase kinase kinase

2.7.11.26 tau-protein kinase

2.7.11.27 [acetyl-CoA carboxylase] kinase

2.7.11.28 tropomyosin kinase

2.7.11.29 low-density-lipoprotein receptor kinase

2.7.11.30 receptor protein serine/threonine kinase

2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase

2.7.11.32 [pyruvate, phosphate dikinase] kinase

2.7.11.33 [pyruvate, water dikinase] kinase

2.7.11.34 NEK6-subfamily protein kinase

2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)

2.7.13 Protein-histidine kinases

2.7.14 Protein-arginine kinases

2.7.99 Other protein kinases

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

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Release 2023.1 (January 2023)