EC Number   |
Expression |
Reference |
|---|
   2.1.1.348 | down |
m6A methyltransferases METTL3 mRNA is decreased in responses to heat shock stress in HepG2 cells |
758170 |
| 2.1.1.348 | up |
hepatitis B X-interacting protein (HBXIP) up-regulates METTL3 by suppressing let-7g, in which METTL3 increases HBXIP expression forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP, leading to accelerated cell proliferation in breast cancer. Expression of METTL3 is positively related to that of HBXIP in clinical breast cancer tissues |
756331 |
| 2.1.1.348 | up |
m6A level for RNA methylation and the expression level of METTL3 are up-regulated in human osteosarcoma tissues and osteosarcoma cell lines |
755980 |
| 2.1.1.348 | up |
m6A methylated RNA level and its N6-methyladenosine methylase METTL3 are consistently up-regulated in the liver tissues from patients with type 2 diabetes. The m6A methylated RNA and METTL3 levels are up-regulated in mouse with 16 weeks high-fat diet, compared with mice fed a standard chow diet |
755983 |
| 2.1.1.348 | up |
the enzyme is significantly up-regulated in human hepatocellular carcinoma and multiple solid tumors |
756898 |
