EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
bone |
- |
699216, 761361 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
bone |
- |
686263, 741242 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
bone |
- |
673845 |
1.13.11.5 | homogentisate 1,2-dioxygenase |
bone |
- |
712909, 712935 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
bone |
embryo |
439200, 439237 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
bone |
represents about 45% of total enzyme activity |
439243 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
bone |
- |
-, 675017, 745431, 746171 |
1.14.11.7 | procollagen-proline 3-dioxygenase |
bone |
- |
672947, 712433 |
1.14.13.8 | flavin-containing monooxygenase |
bone |
- |
673313 |
1.14.15.16 | vitamin D3 24-hydroxylase |
bone |
- |
714836 |
1.14.15.18 | calcidiol 1-monooxygenase |
bone |
- |
674990 |
1.3.5.1 | succinate dehydrogenase |
bone |
- |
686400 |
1.4.3.13 | protein-lysine 6-oxidase |
bone |
leg |
391736, 391740 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
bone |
- |
711688 |
1.8.1.9 | thioredoxin-disulfide reductase |
bone |
- |
658795 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
bone |
- |
712462 |
2.3.1.255 | N-terminal amino-acid Nalpha-acetyltransferase NatA |
bone |
- |
756332, 756675 |
2.3.1.B43 | protein-lysine desuccinylase (NAD+) |
bone |
- |
755970 |
2.4.1.174 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase |
bone |
- |
674881 |
2.4.1.174 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase |
bone |
quantitative gene expression and in situ hybridization of genes associated with endochondral ossification |
-, 760033 |
2.4.1.41 | polypeptide N-acetylgalactosaminyltransferase |
bone |
isozymes ppGalNAcT-1, ppGalNAcT-2, and ppGalNAcT-3, expression patterns, overview. Expression of isozyme ppGalNAcT-1 especially in calvaria and tibia |
704654 |
2.4.1.50 | procollagen galactosyltransferase |
bone |
embryo bone |
439149 |
2.4.1.66 | procollagen glucosyltransferase |
bone |
embryo bone |
439149 |
2.5.1.56 | N-acetylneuraminate synthase |
bone |
- |
739153 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
bone |
- |
709930 |
2.7.1.3 | ketohexokinase |
bone |
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues |
678985 |
2.7.1.36 | mevalonate kinase |
bone |
- |
708647 |
2.7.10.1 | receptor protein-tyrosine kinase |
bone |
ossification centers of developing bone |
690303 |
2.7.11.10 | IkappaB kinase |
bone |
- |
662547 |
2.7.11.19 | phosphorylase kinase |
bone |
- |
676038 |
2.7.11.30 | receptor protein serine/threonine kinase |
bone |
ALK3 |
665487 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
bone |
- |
-, 703618 |
2.7.8.29 | L-serine-phosphatidylethanolamine phosphatidyltransferase |
bone |
- |
740791 |
3.1.3.1 | alkaline phosphatase |
bone |
- |
650752, 652666, 654004, 691134, 707746, 714682, 94567, 94573, 94582, 94625, 94635 |
3.1.3.1 | alkaline phosphatase |
bone |
bone isozyme is of the non-specific type |
653965 |
3.1.3.2 | acid phosphatase |
bone |
- |
134688, 134711, 663766, 665956 |
3.1.3.2 | acid phosphatase |
bone |
cortical bone matrix |
134689 |
3.1.3.2 | acid phosphatase |
bone |
high activity |
652665 |
3.1.3.4 | phosphatidate phosphatase |
bone |
low levels of lipin-2, in bone and bone marrow, at 1020% the levels in liver |
709065 |
3.1.3.48 | protein-tyrosine-phosphatase |
bone |
- |
94976 |
3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
bone |
- |
694494 |
3.1.3.75 | phosphoethanolamine/phosphocholine phosphatase |
bone |
- |
-, 714633, 715704 |
3.1.3.75 | phosphoethanolamine/phosphocholine phosphatase |
bone |
from 3 weeks old male chickens, from tibia, diaphyseal cortical and trabecular bone, expression pattern, PHOSPHO1 is specifically expressed at sites of mineralization in bone and cartilage |
655132 |
3.1.3.75 | phosphoethanolamine/phosphocholine phosphatase |
bone |
high levels in matrix vesicles from growth plate chondrocytes |
678951 |
3.1.3.75 | phosphoethanolamine/phosphocholine phosphatase |
bone |
matrix vesicles |
680993 |
3.1.3.75 | phosphoethanolamine/phosphocholine phosphatase |
bone |
PHOSPHO1 is restricted to mineralizing regions of bone and growth plate. 120fold higher level of PHOSPHO1 expression in bone compared with liver. Enzyme present within matrix vesicles is in an active state. Present in early hypertrophic chondrocytes of the growth plate, and in osteoblasts of trabecular surfaces and infilling primary osteons of cortical bone |
680993 |
3.1.4.40 | CMP-N-acylneuraminate phosphodiesterase |
bone |
- |
135474 |
3.1.4.50 | glycosylphosphatidylinositol phospholipase D |
bone |
expression during embryonic ossification. GPI-PLD is observed during both intramembraneous and endochondral ossification and localized predominantly to the extracellular matrix of chondrocytes and to primary trabecular of the skeleton |
664464 |
3.1.6.4 | N-acetylgalactosamine-6-sulfatase |
bone |
- |
681953 |
3.2.2.29 | thymine-DNA glycosylase |
bone |
proliferating regions of the fetal bone |
694487 |
3.4.11.2 | membrane alanyl aminopeptidase |
bone |
adult |
664240 |
3.4.15.1 | peptidyl-dipeptidase A |
bone |
ACE is expressed in osteoblasts and hypertrophic chondrocytes in the periosteal callus during fracture healing, accompanied by expression of the angiotensin type-1 and type-2 receptors |
707920 |
3.4.21.112 | site-1 protease |
bone |
- |
653621 |
3.4.21.B25 | PACE4 proprotein convertase |
bone |
expression pattern of bone-related genes by RT-PCR/quantitative real-time PCR |
732215 |
3.4.21.B26 | proprotein convertase 5 |
bone |
expressed during mouse development in many tissues including bone and tooth |
753112 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
bone |
malignant mesenchymal cells |
651537 |
3.4.21.B43 | kallikrein 12 |
bone |
- |
679276, 717833 |
3.4.22.38 | cathepsin K |
bone |
- |
-, 695899, 695956, 696041, 696631, 697011, 697012, 697066, 697150, 697257, 697775, 698935, 700549, 708216 |
3.4.22.38 | cathepsin K |
bone |
cathepsin K is increased by a suppressive L-thyroxine therapy and decreases with increasing age, overview |
701297 |
3.4.22.38 | cathepsin K |
bone |
cathepsin K probe localizes adjacent to newly mineralizing bone in vivo |
697010 |
3.4.22.38 | cathepsin K |
bone |
femur and lumbar vertebra |
697009 |
3.4.22.38 | cathepsin K |
bone |
from ankylosing spondylitis and degenerative disc disease patients, strong expression in the different regions of the spine. Cathepsin K-positive multinucleated cells are located at sites of bone destruction, overview |
695609 |
3.4.22.60 | caspase-7 |
bone |
the activated form of caspase-7 is detected from the beginning of ossification during embryonic development and persists postnatally in alveolar and mandibular bones as well as long bones of limbs |
731608 |
3.4.22.B26 | calpain 6 |
bone |
- |
717676 |
3.4.24.14 | procollagen N-endopeptidase |
bone |
- |
668857, 754590 |
3.4.24.19 | procollagen C-endopeptidase |
bone |
- |
733481 |
3.4.24.19 | procollagen C-endopeptidase |
bone |
membranous bones of chick embryos |
31040 |
3.4.24.35 | gelatinase B |
bone |
- |
733208 |
3.4.24.65 | macrophage elastase |
bone |
subchondral |
754996 |
3.4.24.7 | interstitial collagenase |
bone |
- |
-, 753882, 95818 |
3.4.24.79 | pappalysin-1 |
bone |
- |
683711, 753513 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
bone |
- |
638810 |
3.4.24.B11 | ADAMTS1 endopeptidase |
bone |
- |
720086 |
3.4.24.B15 | PHEX peptidase |
bone |
- |
652449, 652458, 719437, 734347, 734358 |
3.4.24.B4 | matrix metalloproteinase-13 |
bone |
- |
711675, 711853, 712131, 712259, 712933 |
3.4.24.B4 | matrix metalloproteinase-13 |
bone |
enzyme is expressed during both intramembranous ossification in skull and endochondral ossification in long bones during gestation |
650906 |
3.4.24.B4 | matrix metalloproteinase-13 |
bone |
MMP13 is expressed by hypertrophic chondrocytes and osteoblasts in the fracture callus |
682484 |
3.4.24.B4 | matrix metalloproteinase-13 |
bone |
mRNA encoding MMP13 is present in multiple cell types involved in human fetal bone development |
712933 |
3.4.24.B4 | matrix metalloproteinase-13 |
bone |
subchondral bone, mRNA expressions of matrix metalloproteinase-13 is significantly enhanced in osteoarthritis subchondral bone osteoblasts compared to subchondral bone osteoblasts without osteoarthritis. The expression of these gene is greater in patients with severe cartilage damage than in those with mild cartilage damage |
693802 |
3.4.24.B4 | matrix metalloproteinase-13 |
bone |
surfaces under the ruffled borders and some clear zones of osteoclasts. MMP-13 may play an important role in the degradation of type I collagen in bone matrix, acting in concert with cathepsin K and MMP-9 produced by osteoclasts |
668095 |
3.5.3.18 | dimethylargininase |
bone |
- |
668120 |
3.6.1.1 | inorganic diphosphatase |
bone |
- |
209799 |
3.6.1.2 | trimetaphosphatase |
bone |
- |
209936 |
3.6.1.9 | nucleotide diphosphatase |
bone |
NPP1 is highly expressed in bone, in bone tissue, NPP1 activity is mainly associated with osteoblast- and chondrocyte-derived membrane structures termed matrix vesicles, where it has been identified as the key diphosphate-generating enzyme ensuring normal bone matrix mineralization and soft tissue calcification |
696406 |
4.1.1.90 | peptidyl-glutamate 4-carboxylase |
bone |
- |
695615, 715064 |
4.2.1.1 | carbonic anhydrase |
bone |
cytosolic peripheral isoenzyme |
680115 |
4.2.1.1 | carbonic anhydrase |
bone |
inner peripheral isoenzyme |
680115 |
4.2.1.1 | carbonic anhydrase |
bone |
integral peripheral isoenzyme |
680115 |
4.2.1.1 | carbonic anhydrase |
bone |
outer peripheral isoenzyme |
680115 |
4.6.1.1 | adenylate cyclase |
bone |
- |
34774, 691574 |
5.3.4.1 | protein disulfide-isomerase |
bone |
activities in adult tissues are only 10-40% of those found in newborn |
3049 |
5.6.2.4 | DNA 3'-5' helicase |
bone |
- |
758107 |
6.2.1.76 | malonate-CoA ligase |
bone |
- |
765555 |