2.3.1.26: sterol O-acyltransferase

This is an abbreviated version!
For detailed information about sterol O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.26

2.3.1.26

keratinocytes

lipoprotein

immortalize

tnf

dermal

esterification

psoriasis

esterify

erk

mapks

chemokine

collagen

atopic

uvb-induced

nanoparticles

atherosclerosis

keratin

cosmetic

dermatitis

caspase-3

drug development

radiation-induced

photoaging

macrophage-derived

cox-2

filaggrin

7alpha-hydroxylase

hairless

sunscreen

nutrition

scratch

pharmacology

sunburn

antiatherosclerotic

phototoxicity

hypocholesterolemic

foam

hmg-coa

photoprotective

desmogleins

dermatology

keratinocyte-derived

ad-like

suprabasal

medicine

cholesterol-fed

hyperproliferation

transdermal

mmp-1

analysis

imiquimod

uvb-irradiated

involucrin

cyclobutane

re-epithelialization

Reaction

Synonyms

A2, ACAT, ACAT-1, ACAT-2, ACAT1, ACAT2, acyl coenzyme A-cholesterol-O-acyltransferase, acyl coenzyme A: cholesteryl acyltransferase, acyl-CoA cholesterol acyltransferase, acyl-CoA cholesterol O-acyltransferase, acyl-CoA: cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase 1, acyl-CoA:cholesterol acyltransferase 2, acyl-coA:cholesterol o-acyl transferase 2, acyl-coenzyme A: cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase 1, acyl-coenzyme A:cholesterol acyltransferase 2, acyl-coenzyme A:cholesterol acyltransferase-1, acyl-coenzyme A:cholesterol O-acyltransferase, acyl-coenzymeA cholesterol acyltransferase, acyl-coenzymeA:cholesterol acyl-transferase, acylcoenzyme A:cholesterol O-acyltransferase, acyltransferase, cholesterol, AsAT, cholesterol acyltransferase, cholesterol acyltransferase 2, cholesterol ester synthase, cholesterol ester synthetase, cholesteryl ester synthetase, hACAT, hACAT-1, hACAT-2, hACAT1, SOAT, SOAT!, Soat1, Soat2, sterol O-acyltransferase 2, sterol-ester synthase, sterol-ester synthetase, steroyl O-acyltransferase 1, steroyl O-acyltransferase 2

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.26 sterol O-acyltransferase

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Results	in table
79	Activating Compound
68	AA Sequence
30	Application
1	CAS Registry Number
48	Cloned(Commentary)
6	Cofactor
4079	Disease/ Diagnostics
6	Expression
32	General Information
487	IC50 Value
513	Inhibitors
28	Ki Value [mM]
35	KM Value [mM]
105	Localization
5	Metals/Ions
26	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
215	Organism
2	Pathway
22	PDB ID
10	pH Optimum
2	pH Range
5	Posttranslational Modification
97	Protein Variants
25	Purification (Commentary)
2	Reaction
32	Reaction Type
184	Reference
13	Renatured (Commentary)
294	Source Tissue
113	Specific Activity [micromol/min/mg]
12	Storage Stability
291	Substrates and Products (Substrate)
13	Subunits
177	Synonyms
1	Systematic Name
49	Temperature Optimum [°C]
5	Temperature Stability [°C]

KM Value

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KM Value on EC 2.3.1.26 - sterol O-acyltransferase

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0.00163 - 0.06

cholesterol

2 entries

0.00000266 - 0.00001218

cis-9-octadecenoyl-CoA

6 entries

0.0022

elaidoyl-CoA

Rattus norvegicus

486674

0.0028

linoleoyl-CoA

Rattus norvegicus

486674

0.0013 - 0.069

oleoyl-CoA

13 entries

0.038

palmitoyl-CoA

Mus musculus

486691

0.0012

pregnenolone

Homo sapiens

O75908, P35610

pH 7.4, 37°C, with cholesterol (0.32 mM). Without cholesterol, the Km for pregnenolone is too high to be measurable

720018

0.0064

stearoyl-CoA

Homo sapiens

pH and temperature not specified in the publication

718887

additional information

14 entries