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11.2
(2E,6E)-8-(N-methyl-2-aminobenzoyloxy)-3,7-dimethyl-2,6-octandien-1-diphosphate
-
pH 7.5, 25°C
0.0000633 - 3.5
(2E,6E)-farnesyl diphosphate
0.00000031
(2E,6E)-farnesyl thiodiphosphate
-
much smaller than using (2E,6E)-farnesyl diphosphate, pH 7.5, 25°C
0.002 - 1.77
(2Z,6E,10E)-geranylgeranyl diphosphate
0.002 - 1.77
(Z,E,E)-Geranylgeranyl diphosphate
0.02
7-(2,6-dimethyl-8-diphospho-2,6-octadienyloxy)-8-methyl-4-trifluoromethyl-chromen-2-one geranyl diphosphate
-
alternative substrate, pH 7.5, 25°C
0.00006 - 2.5
farnesyl diphosphate
1.7
geranyl diphosphate
-
25°C, pH 7.5
0.18 - 2.1
geranylgeranyl diphosphate
0.0002 - 2.5
isopentenyl diphosphate
additional information
additional information
-
0.0000633
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, D26R mutant with 0.5 mM MgCl2
0.0000766
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, D26K mutant with 0.5 mM MgCl2
0.00013
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, S83(Ala)5 mutant
0.00014
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, R77A mutant
0.00022
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, DELTAV82S83 mutant
0.00028
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, DELTAS72 mutant
0.000366
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, D26E mutant with 0.5 mM MgCl2
0.00076
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, DELTAS83 mutant
0.0009
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, S83(Ala)1 mutant
0.00125
(2E,6E)-farnesyl diphosphate
mutant enzyme N77A, pH 7.5, 37°C
0.00155
(2E,6E)-farnesyl diphosphate
mutant enzyme N77Q, pH 7.5, 37°C
0.0025
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H199A/E213A
0.0026
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H43A and mutant E213A
0.00272
(2E,6E)-farnesyl diphosphate
mutant enzyme N77D, pH 7.5, 37°C
0.0033
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant D26A
0.0033
(2E,6E)-farnesyl diphosphate
-
mutant enzyme D26A, pH 7.5, 25°C
0.004
(2E,6E)-farnesyl diphosphate
R80A mutant, pH 7.5, 37°C
0.013
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, without 0.1% Triton
0.0167
(2E,6E)-farnesyl diphosphate
D29A mutant, pH 7.5, 37°C
0.022
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, N74A mutant
0.026
(2E,6E)-farnesyl diphosphate
-
mutant enzyme E213A, pH 7.5, 25°C
0.0542
(2E,6E)-farnesyl diphosphate
R33A mutant, pH 7.5, 37°C
0.095
(2E,6E)-farnesyl diphosphate
-
L85A mutant, 25°C, pH 7.5
0.11
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, S71A mutant
0.151
(2E,6E)-farnesyl diphosphate
mutant enzyme W78D, pH 7.5, 37°C
0.2
(2E,6E)-farnesyl diphosphate
mutant C234A, co-substrate: isopentenyl diphosphate
0.2
(2E,6E)-farnesyl diphosphate
mutant C234A, pH 7.5, temperature not specified in the publication
0.216
(2E,6E)-farnesyl diphosphate
R42G mutant, pH 7.5, 37°C
0.22
(2E,6E)-farnesyl diphosphate
wild-type, co-substrate: isopentenyl diphosphate
0.22
(2E,6E)-farnesyl diphosphate
-
mutant enzyme D218A, pH 7.5, 25°C
0.22
(2E,6E)-farnesyl diphosphate
wild type, pH 7.5, temperature not specified in the publication
0.23
(2E,6E)-farnesyl diphosphate
-
L88A mutant, 25°C, pH 7.5
0.3
(2E,6E)-farnesyl diphosphate
-
mutant enzymes E73A, pH 7.5, 25°C
0.3
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, E73A mutant
0.4
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, E81A mutant
0.434
(2E,6E)-farnesyl diphosphate
mutant enzyme N78R, pH 7.5, 37°C
0.456
(2E,6E)-farnesyl diphosphate
mutant enzyme W78I, pH 7.5, 37°C
0.462
(2E,6E)-farnesyl diphosphate
G32R mutant, pH 7.5, 37°C
0.505
(2E,6E)-farnesyl diphosphate
E76Q mutant, pH 7.5, 37°C
0.61
(2E,6E)-farnesyl diphosphate
-
F89A mutant, 25°C, pH 7.5
0.96
(2E,6E)-farnesyl diphosphate
G32R/R42G mutant, pH 7.5, 37°C
1.09
(2E,6E)-farnesyl diphosphate
E84Q mutant, pH 7.5, 37°C
1.1
(2E,6E)-farnesyl diphosphate
-
mutant enzyme D150A, pH 7.5, 25°C
1.1
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W31F, pH 7.5, 25°C
1.1
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W75F, pH 7.5, 25°C
1.1
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, W75A mutant
1.22
(2E,6E)-farnesyl diphosphate
wild-type enzyme, pH 7.5, 37°C
1.23
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, wild type with 0.05 mM MgCl2
1.5
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W207F, pH 7.5, 25°C
1.66
(2E,6E)-farnesyl diphosphate
wild-type, pH 7.5, 37°C
1.7
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W149F, pH 7.5, 25°C
1.92
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, wild type with 3 mM MgCl2
1.98
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, wild type with 1 mM MgCl2
2.2
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H199A
2.5
(2E,6E)-farnesyl diphosphate
-
wild-type enzyme, pH 7.5, 25°C
2.5
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C
2.5
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, wild type
2.5
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, wild type
2.5
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, recombinant wild-type enzyme
2.5
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W91F, pH 7.5, 25°C
2.5
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, in the presence of 0.1% Triton
2.5
(2E,6E)-farnesyl diphosphate
-
wild type, 25°C, pH 7.5
2.5
(2E,6E)-farnesyl diphosphate
-
wild type, pH 7.5, 25°C
3.5
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W221F, pH 7.5, 25°C
0.002
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme N77A, pH 7.5, 37°C
0.00231
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme N77Q, pH 7.5, 37°C
0.00415
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme N77D, pH 7.5, 37°C
0.00579
(2Z,6E,10E)-geranylgeranyl diphosphate
R80A mutant, pH 7.5, 37°C
0.0258
(2Z,6E,10E)-geranylgeranyl diphosphate
D29A mutant, pH 7.5, 37°C
0.0813
(2Z,6E,10E)-geranylgeranyl diphosphate
R33A mutant, pH 7.5, 37°C
0.3
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme W78D, pH 7.5, 37°C
0.382
(2Z,6E,10E)-geranylgeranyl diphosphate
R42G mutant, pH 7.5, 37°C
0.604
(2Z,6E,10E)-geranylgeranyl diphosphate
E76Q mutant, pH 7.5, 37°C
0.608
(2Z,6E,10E)-geranylgeranyl diphosphate
G32R mutant, pH 7.5, 37°C
0.899
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme W78R, pH 7.5, 37°C
1.07
(2Z,6E,10E)-geranylgeranyl diphosphate
E84Q mutant, pH 7.5, 37°C
1.11
(2Z,6E,10E)-geranylgeranyl diphosphate
G32R/R42G mutant, pH 7.5, 37°C
1.37
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme W78I, pH 7.5, 37°C
1.77
(2Z,6E,10E)-geranylgeranyl diphosphate
wild-type enzyme, pH 7.5, 37°C
1.77
(2Z,6E,10E)-geranylgeranyl diphosphate
wild-type, pH 7.5, 37°C
0.002
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme N77A, pH 7.5, 37°C
0.00231
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme N77Q, pH 7.5, 37°C
0.00415
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme N77D, pH 7.5, 37°C
0.3
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme W78D, pH 7.5, 37°C
0.899
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme W78R, pH 7.5, 37°C
1.37
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme W78I, pH 7.5, 37°C
1.77
(Z,E,E)-Geranylgeranyl diphosphate
wild-type enzyme, pH 7.5, 37°C
0.00006
farnesyl diphosphate
pH 7.5, 25°C, mutant D26R
0.00008
farnesyl diphosphate
pH 7.5, 25°C, mutant D26K
0.0004
farnesyl diphosphate
pH 7.5, 25°C, mutant D26E
0.00125
farnesyl diphosphate
mutant enzyme N77A, pH 7.5, 37°C
0.00155
farnesyl diphosphate
mutant enzyme N77Q, pH 7.5, 37°C
0.002
farnesyl diphosphate
pH 7.5, 30°C, recombinant mutant W210A
0.0025
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H199A/E213A
0.0026
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H43A and mutant E213A
0.00272
farnesyl diphosphate
mutant enzyme N77D, pH 7.5, 37°C
0.003
farnesyl diphosphate
pH 7.5, 30°C, recombinant mutant F207S
0.0033
farnesyl diphosphate
pH 7.5, 25°C, mutant D26A
0.0033
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant D26A
0.015
farnesyl diphosphate
pH 7.5, 30°C, recombinant mutant Y148F
0.0167
farnesyl diphosphate
mutant enzyme D29A, pH 7.5, 37°C
0.0542
farnesyl diphosphate
mutant enzyme R33A, pH 7.5, 37°C
0.071
farnesyl diphosphate
pH 7.5, 30°C, recombinant mutant Y148F
0.095
farnesyl diphosphate
-
pH 7.5, 25°C, mutant L85A
0.11
farnesyl diphosphate
pH 7.5, 30°C, recombinant mutant Y71S
0.151
farnesyl diphosphate
mutant enzyme W78D, pH 7.5, 37°C
0.2
farnesyl diphosphate
mutant C234A, pH 7.5
0.216
farnesyl diphosphate
mutant enzyme R42G, pH 7.5, 37°C
0.22
farnesyl diphosphate
wild-type, pH 7.5
0.23
farnesyl diphosphate
-
pH 7.5, 25°C, mutant L88A
0.434
farnesyl diphosphate
mutant enzyme N78R, pH 7.5, 37°C
0.456
farnesyl diphosphate
mutant enzyme W78I, pH 7.5, 37°C
0.462
farnesyl diphosphate
mutant enzyme G32R, pH 7.5, 37°C
0.505
farnesyl diphosphate
mutant enzyme E76Q, pH 7.5, 37°C
0.61
farnesyl diphosphate
-
pH 7.5, 25°C, mutant F89A
0.96
farnesyl diphosphate
mutant enzyme G32R/R42G, pH 7.5, 37°C
1.09
farnesyl diphosphate
mutant enzyme E84Q, pH 7.5, 37°C
1.22
farnesyl diphosphate
wild-type enzyme, pH 7.5, 37°C
1.22
farnesyl diphosphate
pH 7.5, 30°C, recombinant wild-type enzyme
1.66
farnesyl diphosphate
wild-type enzyme, pH 7.5, 37°C
2.2
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H199A
2.5
farnesyl diphosphate
-
pH 7.5, 25°C, wild-type enzyme
2.5
farnesyl diphosphate
pH 7.5, 25°C, wild-type enzyme
2.5
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant wild-type enzyme
0.18
geranylgeranyl diphosphate
-
pH 7.5, 25°C, mutant L85A
0.18
geranylgeranyl diphosphate
-
L85A mutant, 25°C, pH 7.5
0.32
geranylgeranyl diphosphate
-
pH 7.5, 25°C, mutant L88A
0.32
geranylgeranyl diphosphate
-
L88A mutant, 25°C, pH 7.5
0.7
geranylgeranyl diphosphate
-
pH 7.5, 25°C, mutant F89A
0.7
geranylgeranyl diphosphate
-
F89A mutant, 25°C, pH 7.5
2.1
geranylgeranyl diphosphate
-
pH 7.5, 25°C, wild-type enzyme
2.1
geranylgeranyl diphosphate
-
wild type, 25°C, pH 7.5
0.0002
isopentenyl diphosphate
-
-
0.002
isopentenyl diphosphate
pH 7.5, 30°C, recombinant mutant W210A
0.0025
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H199A/E213A
0.0026
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H43A and mutant E213A
0.0027
isopentenyl diphosphate
mutant enzyme N77Q, pH 7.5, 37°C
0.0033
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant mutant D26A
0.00473
isopentenyl diphosphate
mutant enzyme N77D, pH 7.5, 37°C
0.01
isopentenyl diphosphate
pH 7.5, 30°C, recombinant mutant F207S
0.0164
isopentenyl diphosphate
mutant enzyme N77A, pH 7.5, 37°C
0.071
isopentenyl diphosphate
pH 7.5, 30°C, recombinant mutant Y148F
0.11
isopentenyl diphosphate
pH 7.5, 30°C, recombinant mutant Y71S
0.115
isopentenyl diphosphate
pH 7.5, 30°C, recombinant mutant Y148F
0.2
isopentenyl diphosphate
mutant C234A, co-substrate: farnesyl diphosphate
0.22
isopentenyl diphosphate
wild-type, co-substrate: farnesyl diphosphate
0.397
isopentenyl diphosphate
mutant enzyme W78D, pH 7.5, 37°C
0.783
isopentenyl diphosphate
mutant enzyme W78I, pH 7.5, 37°C
0.803
isopentenyl diphosphate
mutant enzyme W78R, pH 7.5, 37°C
1.55
isopentenyl diphosphate
pH 7.5, 30°C, recombinant wild-type enzyme
1.85
isopentenyl diphosphate
wild-type, pH 7.5, 37°C
2.2
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H199A
2.5
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant wild-type enzyme
additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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-
additional information
additional information
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turnover number for recombinant wild-type enzyme and mutant enzymes Y71S, Y148F, F207S, W210A, W224A
-
additional information
additional information
turnover number for recombinant wild-type enzyme and mutant enzymes Y71S, Y148F, F207S, W210A, W224A
-