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2.5.1.48: cystathionine gamma-synthase

This is an abbreviated version!
For detailed information about cystathionine gamma-synthase, go to the full flat file.

Word Map on EC 2.5.1.48

Reaction

O4-succinyl-L-homoserine
+
L-cysteine
=
L-cystathionine
 +
succinate

Synonyms

AtCGS, CGS, CGS1, CS,26, cystathionine gamma-synthase, cystathionine synthase, cystathionine synthetase, cystathionine-gamma-synthase, EC 4.2.99.9, homoserine O-transsuccinylase, homoserine transsuccinylase, HTS, MetB, O-succinyl-L-homoserine succinate-lyase (adding cysteine), O-succinylhomoserine (Thiol)-lyase, O-succinylhomoserine synthase, O-succinylhomoserine synthetase, synthase, cystathionine gamma-

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.48 cystathionine gamma-synthase

Substrates Products

Substrates Products on EC 2.5.1.48 - cystathionine gamma-synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-cystathionine + acetate
O-acetyl-L-homoserine + L-cysteine
show the reaction diagram
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutyrate
show the reaction diagram
-
beta-elimination
-
?
L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
show the reaction diagram
L-cystathionine + L-cysteine
L-cystathionine + L-cysteine
show the reaction diagram
-
-
observed via 35S-exchange
?
O-acetyl-L-homoserine + 2-mercaptoethanol
S-hydroxyethyl-L-homocysteine + acetate
show the reaction diagram
-
150% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine + acetate
show the reaction diagram
-
50% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine + acetate
show the reaction diagram
-
65% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + allyl mercaptan
S-allyl-L-homocysteine + acetate
show the reaction diagram
-
4% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + benzyl mercaptan
S-benzyl-L-homocysteine + acetate
show the reaction diagram
-
41% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + CH3SH
L-methionine + acetate
show the reaction diagram
-
11% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + D-Cys
D-allocystathionine + acetate
show the reaction diagram
-
101% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + D-homocysteine
meso-homolanthionine + acetate
show the reaction diagram
-
125% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + ethyl mercaptan
L-thionine + acetate
show the reaction diagram
-
24% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + isobutyl mercaptan
S-isobutyl-L-homocysteine + acetate
show the reaction diagram
-
13% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + isopropyl mercaptan
S-isopropyl-L-homocysteine + acetate
show the reaction diagram
-
1% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + L-Cys ethyl ester
S-[(2R)-2-amino-3-ethoxy-3-oxopropyl]-L-homocysteine + acetate
show the reaction diagram
-
15% relative activity to O-acetyl-L-homoserine + L-cysteine
i.e. L-cystathionine monoethyl ester + acetate
?
O-acetyl-L-homoserine + L-Cys methyl ester
S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + acetate
show the reaction diagram
O-acetyl-L-homoserine + L-cysteine
L-cystathionine + acetate
show the reaction diagram
O-acetyl-L-homoserine + L-homocysteine
L-homolanthionine + acetate
show the reaction diagram
-
92% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + m-thiocresol
S-m-tolyl-L-homocysteine + acetate
show the reaction diagram
-
150% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + N-acetyl-L-Cys
S-(L-acetylamino-2-carboxyethyl)-L-homocysteine + acetate
show the reaction diagram
-
12% relative activity to O-acetyl-L-homoserine + L-cysteine
i.e. mono-N-acetyl-L-cystathionine + acetate
?
O-acetyl-L-homoserine + n-butyl mercaptan
S-n-butyl-L-homocysteine + acetate
show the reaction diagram
-
5% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + n-propyl mercaptan
S-n-propyl-L-homocysteine + acetate
show the reaction diagram
-
13% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + o-thiocresol
S-o-tolyl-L-homocysteine + acetate
show the reaction diagram
-
3% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + p-nitrothiophenol
S-p-nitrophenyl-L-homocysteine + acetate
show the reaction diagram
-
41% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + p-thiocresol
S-p-tolyl-L-homocysteine + acetate
show the reaction diagram
-
25% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + phenyl mercaptan
S-phenyl-L-homocysteine + acetate
show the reaction diagram
-
98% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + S2-
L-homocysteine + acetate
show the reaction diagram
-
163% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + sec-butyl mercaptan
S-sec-butyl-L-homocysteine + acetate
show the reaction diagram
-
5% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + tert-butyl mercaptan
S-tert-butyl-L-homosysteine + acetate
show the reaction diagram
-
2% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thioacetic acid
S-acetyl-L-homocysteine + acetate
show the reaction diagram
-
3% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thioglycolate ethyl ester
S-ethoxycarbonyl-L-homocysteine + acetate
show the reaction diagram
-
348% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thioglycolate n-butyl ester
S-n-butoxycarbonyl-L-homocysteine + acetate
show the reaction diagram
-
274% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-acetyl-L-homoserine + thiosalicylic acid
S-o-carboxyphenyl-L-homocysteine + acetate
show the reaction diagram
-
63% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-malonyl-L-homoserine + L-cysteine
L-cystathionine + malonate
show the reaction diagram
-
14% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-phenyl-L-homoserine + L-cysteine
L-cystathionine + phenol
show the reaction diagram
-
1% relative activity to O-acetyl-L-homoserine + L-cysteine
-
?
O-phospho-L-homoserine + L-cysteine
L-cystathionine + phosphate
show the reaction diagram
O-phospho-L-homoserine + L-cysteine ethyl ester
S-[(2R)-2-amino-3-ethoxy-3-oxopropyl]-L-homocysteine + phosphate
show the reaction diagram
-
1% relative activity to O-phospho-L-homoserine + L-cysteine
-
-
?
O-phospho-L-homoserine + L-cysteine methyl ester
S-(L-2-amino-2-methoxycarbonyl)-L-homocysteine + phosphate
show the reaction diagram
-
15% relative activity to O-phospho-L-homoserine + L-cysteine
-
-
?
O-phospho-L-homoserine + L-selenocysteine
selenocystathionine + phosphate
show the reaction diagram
-
-
-
?
O-phospho-L-homoserine + S2-
L-homocysteine + phosphate
show the reaction diagram
O-phospho-L-serine + L-cysteine
?
show the reaction diagram
-
-
-
-
?
O-succinyl-L-homoserine
succinate + pyruvate + NH3
show the reaction diagram
-
elimination reaction
-
-
?
O-succinyl-L-homoserine + 2-mercaptoethanol
S-ethyl-L-homocysteine + succinate
show the reaction diagram
-
32% of the activity with L-cysteine
-
-
?
O-succinyl-L-homoserine + beta-mercaptopropionate
S-carboxyethyl-L-homocysteine + succinate
show the reaction diagram
-
-
-
?
O-succinyl-L-homoserine + CH3SH
L-methionine + succinate
show the reaction diagram
O-succinyl-L-homoserine + D-cysteine
?
show the reaction diagram
-
20% of the activity with L-cysteine
-
-
?
O-succinyl-L-homoserine + H2O
succinate + 2-oxobutyrate + NH3
show the reaction diagram
O-succinyl-L-homoserine + H2S
L-homocysteine + succinate
show the reaction diagram
O-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
show the reaction diagram
O-succinyl-L-homoserine + L-selenocysteine
selenocystathionine + succinate
show the reaction diagram
O-succinyl-L-homoserine + sodium sulfide
L-homocysteine + sodium succinate
show the reaction diagram
-
62% of the activity with L-cysteine
-
-
?
O-succinyl-L-serine + H2O
succinate + pyruvate + NH3
show the reaction diagram
O-succinyl-L-serine + L-cysteine
lanthionine + succinate
show the reaction diagram
-
-
-
?
O-succinyl-L-serine + L-homocysteine
succinate + L-cystathionine
show the reaction diagram
O4-succinyl-L-homoserine + L-cysteine
L-cystathionine + succinate
show the reaction diagram
additional information
?
-