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2.7.1.74: deoxycytidine kinase

This is an abbreviated version!
For detailed information about deoxycytidine kinase, go to the full flat file.

Word Map on EC 2.7.1.74

Reaction

NTP
+
deoxycytidine
=
NDP
 +
dCMP

Synonyms

2'-deoxycytidine kinase, ara-C kinase, arabinofuranosylcytosine kinase, dC kinase, dCK, deoxycytidine kinase, deoxycytidine-cytidine kinase, dNTP:deoxycytidine 5'-phosphotransferase, kinase, deoxycytidine (phosphorylating), NTP:deoxycytidine 5'-phosphotransferase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.74 deoxycytidine kinase

Specific Activity

Specific Activity on EC 2.7.1.74 - deoxycytidine kinase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000057
-
differentiated adipocytes
0.0000521
-
CEM lymphocytes
0.00088
-
cytosine arabinoside-induced cells
0.0048
-
37°C, pH 7.0
0.00523
-
37°C, pH 8.0
0.00632
-
37°C, pH 8.0
0.012
-
37°C, pH 8.0
0.0206
-
37°C, pH 8.0
0.048
-
mitochondrial isozyme, pH 7.5, 37°C
0.072
-
cytoplasmic isozyme I, pH 7.5, 37°C
0.0846
-
37°C, pH 8.0
0.11 - 0.15
-
pH 8.0, 37°C
108
substrate dideoxythymidine, mutant R104M/D133T, pH 7.5, 37°C
114
substrate 2'-deoxy-3'-thiacytidine, mutant R104M/D133T, pH 7.5, 37°C
13.5
-
deoxyadenosine as substrate, 37°C, pH 7.0
135
substrate dideoxythymidine, mutant A100V/R104M/D133T, pH 7.5, 37°C
1387
substrate 1-beta-D-arabinosylcytosine, mutant R104M/D133T, pH 7.5, 37°C
149
substrate 2'-deoxy-3'-thiacytidine, mutant A100V/R104M/D133A, pH 7.5, 37°C
1648
substrate gemcitabine, wild-type, pH 7.5, 37°C
186
substrate dideoxythymidine, mutant A100V/R104M/D133S, pH 7.5, 37°C
206
substrate dideoxythymidine, mutant D47E/R104Q/D133G/N163I/F242L, pH 7.5, 37°C
2262
substrate gemcitabine, mutant A100V/R104M/D133T, pH 7.5, 37°C
26
substrate 2'-deoxy-3'-thiacytidine, mutant A100V/R104M/D133T, pH 7.5, 37°C
270
substrate 2'-deoxy-3'-thiacytidine, mutant A100V/R104M/D133S, pH 7.5, 37°C
28
substrate dideoxythymidine, mutant R104M/D133S, pH 7.5, 37°C
3177
substrate 1-beta-D-arabinosylcytosine, mutant A100V/R104M/D133S, pH 7.5, 37°C
3308
substrate 1-beta-D-arabinosylcytosine, mutant A100V/R104M/D133A, pH 7.5, 37°C
3339
substrate 1-beta-D-arabinosylcytosine, mutant R104M/D133SA, pH 7.5, 37°C
4
-
cytidine as substrate, 37°C, pH 7.0
4267
substrate gemcitabine, mutant R104M/D133T, pH 7.5, 37°C
4400
substrate 1-beta-D-arabinosylcytosine, mutant D47E/R104Q/D133G/N163I/F242L, pH 7.5, 37°C
4530
substrate gemcitabine, mutant A100V/R104M/D133A, pH 7.5, 37°C
545
substrate 2'-deoxy-3'-thiacytidine, mutant R104M/D133S, pH 7.5, 37°C
5624
substrate gemcitabine, mutant R104M/D133SA, pH 7.5, 37°C
599
substrate 1-beta-D-arabinosylcytosine, mutant A100V/R104M/D133T, pH 7.5, 37°C
6.5
substrate dideoxythymidine, wild-type, pH 7.5, 37°C
6009
substrate gemcitabine, mutant A100V/R104M/D133S, pH 7.5, 37°C
64
substrate dideoxythymidine, mutant A100V/R104M/D133A, pH 7.5, 37°C
6460
substrate gemcitabine, mutant D47E/R104Q/D133G/N163I/F242L, pH 7.5, 37°C
7.2
-
deoxyguanosine as substrate, 37°C, pH 7.0
8
-
37°C, pH 7.0
815
substrate 2'-deoxy-3'-thiacytidine, mutant D47E/R104Q/D133G/N163I/F242L, pH 7.5, 37°C
88
substrate 2'-deoxy-3'-thiacytidine, wild-type, pH 7.5, 37°C
984
substrate 1-beta-D-arabinosylcytosine, wild-type, pH 7.5, 37°C
additional information