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2.7.7.15: choline-phosphate cytidylyltransferase

This is an abbreviated version!
For detailed information about choline-phosphate cytidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.15

Reaction

CTP
+
phosphocholine
=
diphosphate
 +
CDP-choline

Synonyms

AtCCT1, CCT, CCT-alpha, CCT1, CCT2, CCTalpha, CCTalpha236, CCTbeta, CCTbeta2, CCTbeta3, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, choline-phosphate cytidylyltransferase A, choline-phosphate cytidylyltransferase-alpha, cholinephosphate cytidylyltransferase, CpCCT1, cpcT, CTalpha, CTbeta2, CTP-phosphocholine cytidylyltransferase, CTP:cholinephosphate cytidylyltransferase, CTP:phosphocholine cytidylyltransferase, CTP:phosphocholine cytidylyltransferase alpha, CTP:phosphocholine cytidylyltransferase alpha-isoform, CTP:phosphocholine cytidylyltransferase beta2, CTP:phosphocholine cytidylyltransferase beta3, CTP:phosphocholine cytidylyltransferase CCT, CTP:phosphocholine cytidylyltransferase-alpha, CTP:phosphocholine cytidylyltransferase-beta2, CTP:phosphocholine cytidylyltranspherase alpha, CTP:phosphorylcholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase CCT1, CTP:phosphorylcholine cytidylyltransferase CCT2, cytidine diphosphocholine pyrophosphorylase, cytidylyltransferase, cytidylyltransferase, choline phosphate, LmjF.18.1330, More, PCYT1A, PF3D7_1316600, PfCCT, phosphocholine cytidylyltransferase, phosphocholine cytidylyltransferase alpha, phosphorylcholine cytidylyltransferase, phosphorylcholine transferase, phosphorylcholine:CTP cytidylyltransferase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.15 choline-phosphate cytidylyltransferase

Inhibitors

Inhibitors on EC 2.7.7.15 - choline-phosphate cytidylyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphatidylcholine
4-chloromercuribenzoate
5,5'-dithiobis(2-nitrobenzoate)
-
-
Blue H-B
-
40% inhibition
Blue MX-R
-
22% inhibition
C2 ceramide
-
-
calpain
-
calpain degrades CCTalpha, 0.6 pmol of calpain effectively cleaves 80% of purified CCTalpha (0.7 pmol) in the absence of calmodulin
-
CDPcholine
-
competitive to choline phosphate
ceramide
chlorpromazine
Dibucaine
-
28% inhibition at 0.05 mM
Green H-4G
-
85% inhibition
-
Levafix E-5BNA
-
40% inhibition
-
lyso-phosphatidylcholine
-
-
lysophosphatidylcholine
Lysosphingolipids
-
reversible
-
N-ethylmaleimide
NaCl
-
inhibitory above 200 mM, 39% inhibition at 300 mM, 67% inhibition at 500 mM
oxidized low density lipoprotein
-
phosphate
phosphodimethylethanolamine
-
competitive to phosphocholine
Phosphoethanolamine
-
competitive to phosphocholine
phosphomonomethylethanolamine
-
competitive to phosphocholine
propanolol
-
28% inhibition at 0.05 mM
Sn-3-Lysophosphatidylcholine
-
-
-
Sphingolipids
-
reversed by activating phospholipids
-
sphingomyelin
-
causes inhibition when present in multilamellar vesicles
sphingosine
Tetracaine
-
50% inhibition at 0.05 mM
Trifluoperazine
-
5fold inhibition of microsomal enzyme at 0.025 mM, 50% inhibition at 0.75mM, addition of saturating amounts of rat liver phospholipid reverses inhibition, no inhibition of hepatocytes at 0.02 mM
Triton X-100
-
-
Tumor necrosis factor alpha
-
-
-
Turquoise H-A
-
40% inhibition
-
Turquoise MX-G
-
85% inhibition
-
Urea
-
50% inhibition of wild-type enzyme at 0.75 M, 50% inhibition of H92N mutant enzyme at 0.35 M, 50% inhibition of H92Q mutant enzyme at 0.2 M
additional information
-