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2.7.7.48: RNA-directed RNA polymerase

This is an abbreviated version!
For detailed information about RNA-directed RNA polymerase, go to the full flat file.

Word Map on EC 2.7.7.48

Reaction

nucleoside triphosphate
+
RNAn
=
diphosphate
 +
RNAn+1

Synonyms

111 kDa protein, 180 kDa protein, 182 kDa protein, 183 kDa protein, 186 kDa protein, 216.5 kDa protein, 2A protein, 3CD protein, 3D pol, 3D polymerase, 3Dpol, 3Dpol-like protein, 3P complex, 69.6 kDa protein, core protein, core protein VP1, CVB3 RdRp, D-elp1, DENV 3 polymerase, DENV 3 RdRp, DENV RdRp, ego-1, ego-11, FluPol, FMDV 3D, GhRdRP, HC-J4 NS5BDELTA21, HCN NS5B protein, HCV NS5B, HCV NS5B polymerase, HCV RdRp, hepatitis C virus polymerase, HRV16 3Dpol, influenza polymerase PA, inner layer protein VP1, JEV NS5, JEV NS5 protein, JEV RdRp, jRdRp, L protein, L/P RdRP, large structural protein, M1 phosphoprotein, MOP1, More, NgRDR1, NIB, nonstructural phosphoprotein, nonstructural protein, nonstructural protein 12, nonstructural protein 5B, NS5, NS5 polymerase, NS5 protein, NS5 RdRp, NS5B, NS5B enzyme, NS5B polymerase, NS5B protein, NS5B RdRp, NS5B RNA-dependent RNA polymerase, NS5b-directed RNA polymerase, NS7, nsp12, nsp4, nucleocapsid phosphoprotein, nucleotidyltransferase, ribonucleate, RNA-dependent, ORF1, ORF1A, ORF1B, OsRDR6, P protein, P180, P3D, P66, P70, P88 protein, p92, PB1, PB1 proteins, PB2, PB2 proteins, Phage f2 replicase, phi6, phi6 polymerase, picornaviral 3D polymerase, plant-encoded RNA-dependent RNA polymerase 1, Pol, Pol IV, polymerase 3Dpol, polymerase acidic protein, polymerase basic 1 protein, polymerase L, protein 3Dpol, proteins PB1, proteins, PB 2, proteins, specific or class, lambda3, of reovirus, proteins, specific or class, PB 1, proteins, specific or class, PB 2, Q-beta replicase, Qbeta replicase, Qbeta-replicase, RDR, RDR1, RDR1a, RDR1b, RDR1c, RDR1c2, RDR2, RDR6, RDRP, replicase, phage f2, replicase, Qbeta, ribonucleic acid replicase, ribonucleic acid-dependent ribonucleate nucleotidyltransferase, ribonucleic acid-dependent ribonucleic acid polymerase, ribonucleic replicase, ribonucleic synthetase, RNA dependent RNA polymerase, RNA nucleotidyltransferase (RNA-directed), RNA polymerase, RNA polymerase IV, RNA replicase, RNA synthetase, RNA transcriptase, RNA-binding protein, RNA-dependent ribonucleate nucleotidyltransferase, RNA-dependent RNA polymerase, RNA-dependent RNA polymerase 1, RNA-Dependent RNA Polymerase 2, RNA-dependent RNA polymerase 6, RNA-dependent RNA polymerase NIb, RNA-dependent RNA polymerase NS5B, RNA-dependent RNA polymerases, RNA-dependent RNA replicase, RNA-dependent RNA-polymerase, RNA-directed RNA polymerase, RNA-directed RNA polymerase L, RNAdependent RNA polymerase, rrf-1, RRF-3, RrpC, RSV RdRp, SARS-CoV-2 RdRp, SARS-CoV-2 RNA polymerase, SARSCoV-2 polymerase, SARSCoV-2-core polymerase complex, self-priming RdRp, sigma NS protein, transcriptase, VP1, VP1 protein, WNV NS5

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.48 RNA-directed RNA polymerase

Activating Compound

Activating Compound on EC 2.7.7.48 - RNA-directed RNA polymerase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-chlorosalicylic acid
2 mM, induction of RdRp gene expression
dithiothreitol
10 mM, required to achieve maximal polymerase activity
Foot-and-Mouth disease virus 3B1
-
acts as primer for RNA synthesis by RNA-dependent RNA polymerase. To act as the primer for positive-strand RNA synthesis, the peptide has to be uridylated to form VpgpU(pU). This reaction is achieved by the RNA-dependent RNA polymerase in the presence of the 3CD precursor plus an internal RNA sequence termed a cis-acting replication element, cre
-
Foot-and-Mouth disease virus 3B2
-
acts as primer for RNA synthesis by RNA-dependent RNA polymerase. To act as the primer for positive-strand RNA synthesis, the peptide has to be uridylated to form VpgpU(pU). This reaction is achieved by the RNA-dependent RNA polymerase in the presence of the 3CD precursor plus an internal RNA sequence termed a cis-acting replication element, cre
-
Foot-and-Mouth disease virus 3B3
-
acts as primer for RNA synthesis by RNA-dependent RNA polymerase. To act as the primer for positive-strand RNA synthesis, the peptide has to be uridylated to form VpgpU(pU). This reaction is achieved by the RNA-dependent RNA polymerase in the presence of the 3CD precursor plus an internal RNA sequence termed a cis-acting replication element, cre
-
host factor
-
hexameric host-coded protein of 12500 Da subunits is required for in vitro Qbeta RNA replication
-
L-protein
the intact L protein is essential for enzyme (RdRP) activity and optimal RNA binding. In truncated L protein constructs, enzyme activity is abrogated due to their deficiency in RNA template binding
-
nsp7
the nsp12 (RdRp) catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors
-
nsp8
the nsp12 (RdRp) catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors
-
phosphoprotein P
-
P is essential for RNA-dependent RNA polymerase function as cofactor. The amino terminus of P is essential for its function in a minireplicon assay. It binds to STAT1 and inhibits interferon-induced Tyr phosphorylation of STAT1, which is not required for P polymerase cofactor function, since mutations in the STAT1 binding motif of P, e.g. G121E, do not affect RNA polymerase function, but abrogate STAT1 inhibition, overview. The gene for NiV P encodes functions that sequester inactive STAT1 in the nucleus, preventing its activation and suggest that the W protein is the dominant inhibitor of STAT1 in NiV-infected cells
-
polypeptide Vpg
-
serves as a primer for addition of the first nucleotide during synthesis of both positive and negative strands. Efficiency and specificity of Vpg uridylylation by picornavirus polymerases is greatly influenced by allosteric effects of ligand binding that are likely to be relevant during viral replicative cyle
-
RanBP5
-
a member of importin beta family, required for PB1/PA heterodimer import into the nucleus, where the active heterotrimer of the enzyme is formed
-
salicylic acid
2 mM, induction of RdRp gene expression
Sodium diethyldithiocarbamate
-
5 mM, great stimulation of template-dependent activity and to a lesser extent template-independent activity
viral protein P10
requirement of the interaction between RNA-dependent RNA polymerase (RdRp) and viral protein P10 via the intrinsically disordered C-terminal domain of RdRp in viral replication and progression of infection in vivo
-
VpgpU(pU)
-
Foot-and-Mouth disease virus 3B peptides acts as primers for RNA synthesis by RNA-dependent RNA polymerase. To act as the primer for positive-strand RNA synthesis, the peptides have to be uridylated to form VPgpU(pU). This reaction is achieved by the RNA-dependent RNA polymerase in the presence of the 3CD precursor plus an internal RNA sequence termed a cis-acting replication element, cre
-
additional information
-