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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
additional information
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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the enzyme should be involved in the replication of BaMV
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
Cystovirus phi6
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
Cystovirus phi6
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template is RNA, the phi6 polymerase is highly processive and can use either single- or double-stranded RNA as a template and synthesizes a full-length complementary strand of an RNA
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
Q6DLV0
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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inducible enzyme
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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replication of Hepatitits C virus is thought to proceed via the initial synthesis of a complementary (-)RNA strand, which serves, in turn, as a template for the production of progeny (+)-strand RNA molecules. An RNA-dependent RNA polymerase is postulated to be involved in these steps
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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essential catalytic enzyme for HCV replication. NS5A binds RNA-dependent RNA polymerase and modulates RNA-dependent RNA polymerase activity
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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NS5B RdRp is essential for viral replication
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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B2 RNA is a substrate for RNA dependent RNA polymerization by Pol II
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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JEV NS5 protein can initiate RNA synthesis through a de novo initiation mechanism. JEV NS5 protein is more efficient in using negative-strand RNA templates, indicating that the JEV NS5 protein is involved in regulating the ratio of positive strand RNA to negative strand RNA
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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JEV NS5 protein can initiate RNA synthesis through a de novo initiation mechanism. JEV NS5 protein is more efficient in using negative-strand RNA templates, indicating that the JEV NS5 protein is involved in regulating the ratio of positive strand RNA to negative strand RNA
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
La France isometric virus
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the enzyme is probably a transcriptase engaged in the synthesis of ssRNA transcripts corresponding to each of the virion-associated dsRNAs
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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the enzyme catalyzes cap methylation of virus-specific mRNA as well as RNA synthesis
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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composed of one phage-coded polypeptide and three host-supplied polypeptides which function in the biosynthesis of proteins in the uninfected host. Two of theses polypeptides, protein elongation factors EF-Tu and EF-Ts, are required for initiation of transcription by replicase with all templates
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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Qbeta replicase is an RNA-dependent RNA polymerase responsible for replicating the RNA genome of coliphage Qbeta and plays a key role in the life cycle of the Qbeta phage
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
the enzyme (RdRP) is essential for both transcription and replication of the viral RNA genome
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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required for replication of the HRV RNA genome
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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key enzyme of replication
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
essential enzyme for viral RNA replication
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
key enzyme responsible for the SARS-CoV-2 replication process, catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA. Identification of potential key agents for targeting RNA-dependent RNA polymerase of SARS-CoV-2 by integrated analysis and virtual drug screening
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
RNA-dependent RNA polymerase is a key enzyme which regulates the viral replication of SARS-CoV-2
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
the enzyme plas a key role in the replication of SARS-CoV-2
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
the enzyme plays a crucial role in SARS-CoV-2 replication
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
the nsp12 (RdRp) is a central component of SARS-CoV-2 replication/transcription machinery. It catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nsP4 possesses the RNA-dependent RNA polymerase activity required for the replication of the SIN genome and transcription of a subgenomic mRNA during infection
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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key step in the reproduction of plus-stranded RNA viruses pathogens is replication of their single-stranded RNA genomes occuring in the cytosol of host cells in association with membranes and requiring a virally-encoded RNA-dependent RNA polymerase
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nucleoside triphosphate + RNAn
diphosphate + RNAn+1
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additional information
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systemic necrotic spotting induced by ORMV in tobacco maps to the RdRp polymerase domain, comparison of necrotic lesions of wild-type and chimeric mutant virusses
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additional information
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NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis
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additional information
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NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis
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additional information
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D-elp1, corresponding to the largest of the three subunits in the RNA polymerase II core elongator complex, has RNA-dependent RNA polymerase activity. RdRP activity is associated with the amino terminal 96-kD fragment, DELTAC, CDS 1-2528. D-elp1 is a noncanonical RdRP that can synthesize dsRNA from different ssRNA templates using either a primer-dependent or primer-independent initiation mechanism, overview. D-elp1 associates tightly with Dcr-2
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additional information
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cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with pre-mRNA processing factor 8, Prp8. Identification of potential protein targets of EV71 3Dpol by MALDI-TOF MS analysis, overview
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additional information
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cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with pre-mRNA processing factor 8, Prp8. Identification of potential protein targets of EV71 3Dpol by MALDI-TOF MS analysis, overview
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additional information
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enzyme-host membrane interactions are an initial step of FHV RNA replication complex assembly, overview
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additional information
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the initiation of FMDV RNA synthesis is strongly inhibited by 5-fluorouridine triphosphate, and it is also an inhibitor of FMDV RNA elongation, overview
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additional information
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the enzyme consists of the phosphoprotein and the large protein, that are both essential for viral synthesis
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additional information
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RNA polymerase II (PolII) acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA. Pol II extends B2 RNA by 18 nt on its 3'-end in an internally templated reaction. The RNA product resulting from extension of B2 RNA by the Pol II RdRP can be removed from Pol II by a factor present in nuclear extracts
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additional information
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the enzyme consists of the phosphoprotein and the large protein, that are both essential for viral synthesis
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additional information
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the RNA polymerase complex consists of three subunits, PB1, PB2, and PA. These polymerase subunits and nucleoprotein, together with the viral RNA, form the viral ribonucleoprotein complex, which is the minimum component for viral RNA replication and transcription
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additional information
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NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis
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additional information
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flaviviral RNA-dependent RNA polymerases initiate replication of the single-stranded RNA genome in the absence of a primer. The template sequence 5'-CU-3' at the 3'-end of the flaviviral genome is highly conserved. Flaviviral RdRps require high concentrations of the second incoming nucleotide GTP to catalyze de novo template-dependent RNA synthesis. the conserved motif F of jRdRp occupies multiple conformations in absence of GTP. Motif F becomes ordered on GTP binding and occludes the nucleotide triphosphate entry tunnel
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additional information
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flaviviral RNA-dependent RNA polymerases initiate replication of the single-stranded RNA genome in the absence of a primer. The template sequence 5'-CU-3' at the 3'-end of the flaviviral genome is highly conserved. Flaviviral RdRps require high concentrations of the second incoming nucleotide GTP to catalyze de novo template-dependent RNA synthesis. the conserved motif F of jRdRp occupies multiple conformations in absence of GTP. Motif F becomes ordered on GTP binding and occludes the nucleotide triphosphate entry tunnel
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additional information
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NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis
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additional information
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flaviviral RNA-dependent RNA polymerases initiate replication of the single-stranded RNA genome in the absence of a primer. The template sequence 5'-CU-3' at the 3'-end of the flaviviral genome is highly conserved. Flaviviral RdRps require high concentrations of the second incoming nucleotide GTP to catalyze de novo template-dependent RNA synthesis. the conserved motif F of jRdRp occupies multiple conformations in absence of GTP. Motif F becomes ordered on GTP binding and occludes the nucleotide triphosphate entry tunnel
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additional information
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the RNA-dependent RNA polymerase of arenaviruses is an integral part of the L protein, a 200-kDa multifunctional and multidomain protein, structure and function of the Lassa virus RdRp domain, folding model of thedomain, overview
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additional information
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the enzyme consists of the phosphoprotein and the large protein, that are both essential for viral synthesis
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additional information
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the enzyme consists of the phosphoprotein and the large protein, that are both essential for viral synthesis
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additional information
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the enzyme consists of the phosphoprotein and the large protein, that are both essential for viral synthesis
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additional information
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pseudogene-derived antisense siRNAs can be produced in specific rice developmental stages or physiological growth conditions, suggesting their potentially important roles in normal rice development involving RDR2, or small RNAs from rice pseudogenes might also function as natural antisense siRNAs either by interacting with the complementary sense RNAs from functional parental genes or by forming double-strand RNAs with transcripts of adjacent paralogous pseudogenes, function classification of rice pseudogenes, overview
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additional information
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Potato spindle tuber viroid replication in the nucleoplasm generates (-)-PSTVd intermediates and (+)-PSTVd copies. The Nicotiana benthamiana canonical 9-zinc finger (ZF) transcription factor IIIA (TFIIIA-9ZF) as well as its variant TFIIIA-7ZF both interact with (+)-PSTVd, but only TFIIIA-7ZF interacts with (-)-PSTVd. TFIIIA-7ZF is found in the nucleoplasm and nucleolus, in contrast to the strictly nucleolar localization of TFIIIA-9ZF. The DNA-dependent RNA polymerase II interacts with the (+)- and (2)-PSTVd RNA in vivo
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additional information
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RHDV polyprotein cleavage product p58 is an active RNA-dependent RNA polymerase, that has no DNA-dependent RNA polymerase activity
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additional information
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RHDV polyprotein cleavage product p58 is an active RNA-dependent RNA polymerase, that has no DNA-dependent RNA polymerase activity
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additional information
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RHDV polyprotein cleavage product p58 is an active RNA-dependent RNA polymerase, that has no DNA-dependent RNA polymerase activity
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additional information
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the enzyme consists of the phosphoprotein and the large protein, that are both essential for viral synthesis
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additional information
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the C-terminal fragment can interact with the viral nucleocapsid protein, the N-terminal 50 amino acids of nucleocapsid protein are responsible for the NP-RdRp interaction
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additional information
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NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis
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additional information
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NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis
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additional information
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comparison of necrotic lesions of wild-type and chimeric mutant virusses
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additional information
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The single-stranded RNA genomes of the plus-stranded RNA viruses serve as templates for translation of viral proteins and perform other essential functions that generally involve local RNA structures, such as RNA hairpins. Viral RNA replication also requires a long-range RNA-RNA interaction
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additional information
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NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis
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additional information
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NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis
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additional information
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NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis
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