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1.1.1.176: 12alpha-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 12alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Wordmap for 1.1.1.176

Word Map on EC 1.1.1.176 Wordmap for 1.1.1.176

Reaction

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cholate
+
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NADP+
=
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3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate
+
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NADPH
+
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H+

Synonyms

12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, CDD59475, dehydrogenase, 12alpha-hydroxy steroid, Elen_2515, NAD+-dependent 12alpha-HSDH, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP+-dependent 12alpha-HSDH, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                EC 1.1.1.1761.1.1.176 12alpha-hydroxysteroid dehydrogenase

Temperature Stability

Temperature Stability on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

for references in articles please use BRENDA:EC1.1.1.176

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0 - 4
-
half-life: 11 days
25
-
half-life: 4 days, increases to 10 days by addition of NADP+
30
-
half-life: 2 days, increases to 5 days by addition of NADP+
43
-
slow inactivation
50
-
30 min, inactivation
56
-
rapid inactivation