1.1.1.88: hydroxymethylglutaryl-CoA reductase

This is an abbreviated version, for detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.

Reaction

(R)-mevalonate
+
CoA
 + 2 NAD+ =
3-hydroxy-3-methylglutaryl-CoA
 + 2 NADH + 2 H+

Synonyms

3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, NADH-dependent HMG-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.88 hydroxymethylglutaryl-CoA reductase

Reference

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Reference on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fimognari, G.M.; Rodwell, V.W.
Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA)
Biochemistry
4
2086-2090
1965
Mycobacterium sp., Mycobacterium sp. s4, Pseudomonas mevalonii
-
Manually annotated by BRENDA team
Bensch, W.R.; Rodwell, V.W.
Purification and properties of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Pseudomonas
J. Biol. Chem.
245
3755-3762
1970
Pseudomonas mevalonii
Manually annotated by BRENDA team
Rodwell, V.W.; Bensch, W.R.
S-3-Hydroxy-3-methylglutaryl-CoA reductase from Pseudomonas
Methods Enzymol.
71
480-486
1981
Pseudomonas mevalonii
Manually annotated by BRENDA team
Gill, J.F.; Beach, M.J.; Rodwell, V.W.
Mevalonate utilization in Pseudomonas sp. M. Purification and characterization of an inducible 3-hydroxy-3-methylglutaryl coenzyme A reductase
J. Biol. Chem.
260
9393-9398
1985
Pseudomonas mevalonii
Manually annotated by BRENDA team
Jordan-Starck, T.C.; Rodwell, V.W.
Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA reductase. Characterization and chemical modification
J. Biol. Chem.
264
17913-17918
1989
Pseudomonas mevalonii
Manually annotated by BRENDA team
Jordan-Starck, T.C.; Rodwell, V.W.
Role of cysteine residues in Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA reductase. Site-directed mutagenesis and characterization of the mutant enzymes
J. Biol. Chem.
264
17919-17923
1989
Pseudomonas mevalonii
Manually annotated by BRENDA team
Beach, M.J.; Rodwell, V.W.
Cloning, sequencing, and overexpression of mvaA, which encodes Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase
J. Bacteriol.
171
2994 - 3001
1989
Pseudomonas mevalonii
Manually annotated by BRENDA team
Darnay, B.G.; Wang, Y.; Rodwell, V.W.
Identification of the catalytically important histidine of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
J. Biol. Chem.
267
15064-15070
1992
Pseudomonas mevalonii
Manually annotated by BRENDA team
Sato, R.; Goldstein, J.L.; Brown, M.S.
Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion
Proc. Natl. Acad. Sci. USA
90
9261-9265
1993
Mesocricetus auratus
Manually annotated by BRENDA team
Lawrence, C.M.; Rodwell, V.W.; Stauffacher, C.V.
Crystal structure of Pseudomonas mevalonii HMG-CoA reductase at 3.0 Angstrom resolution
Science
268
1758-1762
1995
Pseudomonas mevalonii
Manually annotated by BRENDA team
Friesen, J.A.; Lawrence, C.M.; Stauffacher, C.V.; Rodwell, V.W.
Structural determinants of nucleotide coenzyme specificity in the distinctive dinucleotide binding fold of HMG-CoA reductase from Pseudomonas mevalonii
Biochemistry
35
11945-11950
1996
Pseudomonas mevalonii
Manually annotated by BRENDA team
Rogers, K.S.; Rodwell, V.W.; Geiger, P.
Active form of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase
Biochem. Mol. Med.
61
114-120
1997
Pseudomonas mevalonii
Manually annotated by BRENDA team
Tabernero, L.; Bochar, D.A.; Rodwell, V.W.; Stauffacher, C.V.
Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase
Proc. Natl. Acad. Sci. USA
96
7167-7177
1999
Pseudomonas mevalonii (P13702)
Manually annotated by BRENDA team
Bochar, D.A.; Tabernero, L.; Stauffacher, C.V.; Rodwell, V.W.
Aminoethylcysteine can replace the function of the essential active site lysine of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase
Biochemistry
38
8879-8883
1999
Pseudomonas mevalonii
Manually annotated by BRENDA team
Ayora-Talavera, T.; Chappell, J.; Lozoya-Gloria, E.; Loyola-Vargas, V.M.
Overexpression in Catharanthus roseus hairy roots of a truncated hamster 3-hydroxy-3-methylglutaryl-CoA reductase gene
Appl. Biochem. Biotechnol.
97
135-145
2002
Mesocricetus auratus
Manually annotated by BRENDA team
Crane, Y.M.; Korth, K.L.
Regulated accumulation of 3-hydroxy-3-methylglutaryl CoA reductase protein in potato cell cultures: Effects of calcium and enzyme inhibitors
J. Plant Physiol.
159
1301-1307
2002
Solanum tuberosum
-
Manually annotated by BRENDA team
Hedl, M.; Rodwell, V.W.
Inhibition of the Class II HMG-CoA reductase of Pseudomonas mevalonii
Protein Sci.
13
1693-1697
2004
Pseudomonas mevalonii
Manually annotated by BRENDA team
Azenabor, A.A.; Kennedy, P.; Balistreri, S.
Chlamydia trachomatis Infection of Human Trophoblast Alters Estrogen and Progesterone Biosynthesis: an insight into role of infection in pregnancy sequelae
Int. J. Med. Sci.
4
223-231
2007
Homo sapiens
Manually annotated by BRENDA team
Shirai, N.; Suzuki, H.
Effect of docosahexaenoic acid on brain 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in male ICR mice
J. Nutr. Biochem.
18
488-494
2007
Mus musculus
Manually annotated by BRENDA team
Kevei, Z.; Lougnon, G.; Mergaert, P.; Horvath, G.V.; Kereszt, A.; Jayaraman, D.; Zaman, N.; Marcel, F.; Regulski, K.; Kiss, G.B.; Kondorosi, A.; Endre, G.; Kondorosi, E.; Ane, J.
3-hydroxy-3-methylglutaryl coenzyme a reductase1 interacts with NORK and is crucial for nodulation in Medicago truncatula
Plant Cell
19
3974-3989
2007
Medicago truncatula
Manually annotated by BRENDA team
Perchellet, J.P.; Perchellet, E.M.; Crow, K.R.; Buszek, K.R.; Brown, N.; Ellappan, S.; Gao, G.; Luo, D.; Minatoya, M.; Lushington, G.H.
Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins
Int. J. Mol. Med.
24
633-643
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Yu, Q.; Liu, L.; Wang, Y.
Expression of low-density lipoprotein receptors and hydroxy methylglutaryl-coenzyme A-reductase in human pterygium
Int. J. Ophthal.
9
284-285
2009
Homo sapiens
-
Manually annotated by BRENDA team
Martini, C.; Trapani, L.; Narciso, L.; Marino, M.; Trentalance, A.; Pallottini, V.
3-Hydroxy 3-methylglutaryl coenzyme A reductase increase is essential for rat muscle differentiation
J. Cell. Physiol.
220
524-530
2009
Rattus norvegicus
Manually annotated by BRENDA team
Slotta, J.; Laschke, M.; Wang, Y.; Schilling, M.; Menger, M.; Thorlacius, H.
Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury
J. Investig. Med.
57
645-649
2009
Mus musculus
Manually annotated by BRENDA team
Ma, S.M.; Garcia, D.E.; Redding-Johanson, A.M.; Friedland, G.D.; Chan, R.; Batth, T.S.; Haliburton, J.R.; Chivian, D.; Keasling, J.D.; Petzold, C.J.; Lee, T.S.; Chhabra, S.R.
Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases
Metab. Eng.
13
588-597
2011
Bordetella petrii, Delftia acidovorans, Pseudomonas mevalonii
Manually annotated by BRENDA team