1.14.12.25: p-cumate 2,3-dioxygenase

This is an abbreviated version!
For detailed information about p-cumate 2,3-dioxygenase, go to the full flat file.

Reaction

p-cumate
+
NADH
+
H+
+
O2
=
(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate
+
NAD+

Synonyms

CmtAa, CmtAb, CmtAc, CmtAd, p-cumate dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.25 p-cumate 2,3-dioxygenase

Natural Substrates Products

Natural Substrates Products on EC 1.14.12.25 - p-cumate 2,3-dioxygenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
p-cumate + NADH + H+ + O2
(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+
show the reaction diagram
-
-
-
-
?
p-cumate + NADH + H+ + O2
2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+
show the reaction diagram
-
-
the substrate for the ring cleavage of 2,3-dihydroxy-p-cumate is formed from p-cumate in two reactions via a dihydrodiol intermediate (2,3-dihydroxy-4-isopropylcyclohexa-4,6-dienoate). Both hydroxyl atoms of the dihydrodiol are derived from the same molecule of 02
-
?