1.14.14.17: squalene monooxygenase
This is an abbreviated version!
For detailed information about squalene monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.17
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1.14.14.17
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cholesterol
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sterol
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terbinafine
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ergosterol
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trichophyton
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mevalonate
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lanosterol
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allylamine
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2,3-oxidosqualene
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hmg-coa
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itraconazole
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mentagrophytes
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rubrum
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oxidosqualene
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terbinafine-resistant
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tellurium
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tinea
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naftifine
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interdigitale
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antimycotic
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bloch
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griseofulvin
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dammarenediol
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dermatophytoses
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cycloartenol
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beta-amyrin
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medicine
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corporis
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drug development
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nutrition
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biotechnology
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pharmacology
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cholesterogenic
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synthesis
- 1.14.14.17
- cholesterol
- sterol
- terbinafine
- ergosterol
- trichophyton
- mevalonate
- lanosterol
- allylamine
- 2,3-oxidosqualene
- hmg-coa
- itraconazole
- mentagrophytes
- rubrum
- oxidosqualene
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terbinafine-resistant
- tellurium
- tinea
- naftifine
- interdigitale
-
antimycotic
-
bloch
-
griseofulvin
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dammarenediol
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dermatophytoses
- cycloartenol
- beta-amyrin
- medicine
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corporis
- drug development
- nutrition
- biotechnology
- pharmacology
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cholesterogenic
- synthesis
Reaction
Synonyms
CYP17, cytochrome P450 17alpha hydroxylase/17,20 lyase, EC 1.14.13.132, EC 1.14.99.7, Erg1, Erg1 protein, Erg1p, hydroxylase, squalene, oxygenase, squalene mono-, PgSQE1, PgSQE2, SE, SE1, SE3, SQE, SQE-I, SQE-II, sqe1, SQE3, SQLE, squalen expoxidase, squalene 2,3-epoxidase, squalene 2,3-oxidocyclase, squalene epoxidase, squalene epoxidase 1, squalene epoxidase 3, squalene hydroxylase, squalene mono-oxygenase, squalene oxydocyclase, squalene-2,3-epoxidase, squalene-2,3-epoxide cyclase, TkSQE1, TkSQE2, TkSQE3, TkSQE4
ECTree
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General Information
General Information on EC 1.14.14.17 - squalene monooxygenase
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malfunction
metabolism
physiological function
additional information
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enzyme downregulation inhibits the tumorigenicity of hepatocellular carcinoma cells in vitro and in vivo
malfunction
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squalene epoxidase inhibition may be responsible for dermatitis and neuropathy
malfunction
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squalene epoxidase inhibition may be responsible for dermatitis and neuropathy
metabolism
B7TWW5, Q75W20
squalene epoxidase catalyzes the first oxygenation step in phytosterol and triterpenoid saponin biosynthesis and is suggested to represent one of the rate-limiting enzymes in this pathway. Expression of PgSQE1 and PgSQE2 are regulated in a different manner
metabolism
B7TWW5, Q75W20
squalene epoxidase catalyzes the first oxygenation step in phytosterol and triterpenoid saponin biosynthesis and is suggested to represent one of the rate-limiting enzymes in this pathway. Expression of PgSQE1 and PgSQE2 are regulated in a different manner, and that PgSQE1 regulates ginsenoside biosynthesis, but not that of phytosterols in Panax ginseng
metabolism
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squalene epoxidase is a key FAD-dependent enzyme of ergosterol and cholesterol biosynthetic pathways
metabolism
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the enzyme plays a pivotal role in the maintenance of cholesterol homeostasis
metabolism
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the enzyme plays a pivotal role in the maintenance of cholesterol homeostasis
metabolism
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the isoform SQE3 is able to complement isoform SQE1 function
metabolism
Q9UNR6
enzyme undergoes cholesterol-dependent proteasomal degradation when cholesterol is in excess. The amphipathic helix within the first 100 amino acids of squalene monooxygenase attaches reversibly to the ER membrane depending on cholesterol levels. With excess, the helix is ejected and unravels, exposing a hydrophobic patch, which then serves as a degradation signal
metabolism
the enzyme catalyzes a key steps in the biosynthesis of cyclic terpenoids
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squalene epoxidase promotes the growth and migration of the hepatocellular carcinoma cells
physiological function
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the enzyme is important for embryo development and bulk squalene epoxidase activity
physiological function
introduction of the SQE-I gene into Saccharomyces cerevisiae erg1 mutants results in the complementation of ergosterol auxotrophy
physiological function
isoform SE1 may participate in the epoxidation reaction to form 2,3-oxidosqualene
physiological function
isoform SE3 may participate in the epoxidation reaction to form 2,3-oxidosqualene
physiological function
rates of myogenesis and adipogenesis induced in C2C12 cells and 3T3-L1 cells, respectively, are decreased by squalene epoxidase knockdown. The expression of myogenic marker genes (Myog, Myod, and Myh4) and adipogenic marker genes (Pparg, Cebpa, and Adipoq) is substantially downregulated in cells transfected with squalene epoxidase siRNA. mRNA expression levels of ROS scavengers, which affect meat quality by altering protein oxidation processes, are significantly downregulated by squalene epoxidase knockdown
physiological function
squalene epoxidase overexpression upregulates lanosterol synthase gene expression in the biosynthetic pathway and stimulates ganoderic acid accumulation
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silencing of PgSQE1 in RNAi roots strongly upregulates PgSQE2 and PNX, cycloartenol synthase, and results in enhanced phytosterol accumulation
additional information
silencing of PgSQE1 in RNAi roots strongly upregulates PgSQE2 and PNX, cycloartenol synthase, and results in enhanced phytosterol accumulation
additional information
Q75W20
silencing of PgSQE1 in RNAi roots strongly upregulates PgSQE2 and PNX, cycloartenol synthase, and results in enhanced phytosterol accumulation