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Information on EC 1.14.14.17 - squalene monooxygenase

for references in articles please use BRENDA:EC1.14.14.17

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IUBMB Comments

A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7, lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH—hemoprotein reductase [5,7].

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
squalene epoxidase, squalene monooxygenase, erg1p, erg1 protein, pgsqe1, pgsqe2, tksqe1, squalene-2,3-epoxide cyclase, squalene mono-oxygenase, squalene epoxidase 1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
squalene + [reduced NADPH-hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram