1.2.1.27: methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

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For detailed information about methylmalonate-semialdehyde dehydrogenase (CoA-acylating), go to the full flat file.

Word Map on EC 1.2.1.27

Reaction

2-Methyl-3-oxopropanoate
+
CoA
+
H2O
+
NAD+
=
propanoyl-CoA
+
HCO3-
+
NADH

Synonyms

Aldh6a1, dddC, FG99_15390, KES23460, malonate-semialdehyde dehydrogenase, methylmalonate semialdehyde dehydrogenase, methylmalonate semialdehyde dehydrogenase protein, methylmalonate-semialdehyde dehydrogenase, methylmalonic acid semialdehyde dehydrogenase, MMSADH, MMSDH, MSDH, NAD-dependent malonate-semialdehyde dehydrogenase, OdoMMSDH, OsALDH6, PA3570, SSO1218

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

Systematic Name

Systematic Name on EC 1.2.1.27 - methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

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SYSTEMATIC NAME
IUBMB Comments
2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
Also converts 3-oxopropanoate into acetyl-CoA [3]. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding [3]. Bicarbonate rather than CO2 is released as a final product [3].