1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring)
This is an abbreviated version!
For detailed information about oxoglutarate dehydrogenase (succinyl-transferring), go to the full flat file.
Word Map on EC 1.2.4.2
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1.2.4.2
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succinate
-
tricarboxylic
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malate
-
isocitrate
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tca
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thiamin
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citrate
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dehydrogenases
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krebs
-
dihydrolipoamide
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citric
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neurodegenerative
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lipoylation
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alzheimer
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lipoic
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lipoamide
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aconitase
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branched-chain
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transketolase
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succinylation
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intramitochondrial
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succinyl-coa
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oxaloacetate
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hexokinase
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acidosis
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glyoxylate
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glutamicum
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fumarase
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encephalopathy
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antimitochondrial
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glutaminase
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pigeon
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alpha-ketoacids
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aciduria
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thiamine-dependent
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thiamine-deficient
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ca2+-sensitive
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2-oxo-acid
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anaplerotic
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6-phosphofructokinase
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wernicke
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ketoacids
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dihydrolipoate
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thiokinase
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1.2.4.1
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diphosphate-dependent
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nadh-linked
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malate-aspartate
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pdc-e2
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industry
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synthesis
- 1.2.4.2
- succinate
-
tricarboxylic
- malate
- isocitrate
- tca
- thiamin
- citrate
- dehydrogenases
-
krebs
- dihydrolipoamide
-
citric
- neurodegenerative
-
lipoylation
- alzheimer
-
lipoic
- lipoamide
- aconitase
-
branched-chain
- transketolase
-
succinylation
-
intramitochondrial
- succinyl-coa
- oxaloacetate
- hexokinase
- acidosis
- glyoxylate
- glutamicum
- fumarase
- encephalopathy
-
antimitochondrial
- glutaminase
-
pigeon
- alpha-ketoacids
-
aciduria
-
thiamine-dependent
-
thiamine-deficient
-
ca2+-sensitive
- 2-oxo-acid
-
anaplerotic
- 6-phosphofructokinase
- wernicke
-
ketoacids
- dihydrolipoate
- thiokinase
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1.2.4.1
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diphosphate-dependent
-
nadh-linked
-
malate-aspartate
- pdc-e2
- industry
- synthesis
Reaction
Synonyms
2-ketoglutarate dehydrogenase, 2-OGDH, 2-OGDH E1, 2-OGDH1, 2-OGDH2, 2-oxoadipate dehydrogenase, 2-oxoglutarate decarboxylase, 2-oxoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex E1 component, 2-oxoglutarate dehydrogenase E1/E2 component, 2-oxoglutarate dehydrogenase-like protein, 2-oxoglutarate:lipoate oxidoreductase, 2OGDH, AKGDH, alpha-ketoglutarate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, alpha-ketoglutarate dehydrogenase multienzyme complex, alpha-ketoglutaric acid dehydrogenase, alpha-ketoglutaric dehydrogenase, alpha-KGD, alpha-KGDH, alpha-KGDHC, alpha-oxoglutarate dehydrogenase, alphaKGDH, At3g55410, dehydrogenase, oxoglutarate, DHTKD1, E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex, E1 subunit of the alpha-ketoglutarate dehydrogenase complex, E1-OGDH1, E1-OGDH2, E1a, E1k, E1o, E1o component, E1o component 2-oxoglutarate dehydrogenase complex, ELK, ilvB, KDH, Kdh E1, ketoglutaric dehydrogenase, KG dehydrogenase, Kgd, KGDH, KGDHC, MPA24.10, OADH, ODH, OdhA, OGDC, OGDH, OGDHC, OGDHL, oxoglutarate decarboxylase, oxoglutarate dehydrogenase, SucA, ThDP-dependent 2-oxoglutarate dehydrogenase
ECTree
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.2.4.2 - oxoglutarate dehydrogenase (succinyl-transferring)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-oxo-5-hexenoic acid + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-pent-4-enoyldihydrolipoyllysine + CO2
-
2-oxo-5-hexenoic acid is not a substrate for wild-type
-
-
?
2-oxoadipate + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
2-oxoadipate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine + CO2
2-oxoglutarate + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
2-oxovalerate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-butanoyldihydrolipoyllysine + CO2
-
2-oxovalerate is not a substrate for wild-type
-
-
?
2-oxoadipate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine + CO2
-
-
-
?
2-oxoadipate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine + CO2
-
-
-
?
2-oxoadipate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine + CO2
-
-
-
?
2-oxoglutarate + 2,6-dichlorophenolindophenol
?
-
-
-
?
2-oxoglutarate + 2,6-dichlorophenolindophenol
?
-
-
-
?
2-oxoglutarate + lipoamide
S-succinyldihydrolipoamide + CO2
-
-
-
-
?
2-oxoglutarate + lipoamide
S-succinyldihydrolipoamide + CO2
-
transcription of the 2-oxoglutarate dehydrogenase component of the 2-oxoglutarate dehydrogenase complex is regulated by glucose and activated by the products of HAP2 and HAP3
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
ir
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
ir
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
ir
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
ir
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
ir
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
ir
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
-
-
-
?
additional information
?
-
-
enzyme also catalyzes the production of H2O2 in vivo, in vitro, and in situ from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a atrget for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview
-
-
?
additional information
?
-
-
OdhA can utilize free dihydrodilipoamide to perform the E2 reaction specifically with succinyl-CoA. OdhA specifically catalyzes the E1 and E2 reaction to convert 2-oxoglutarate to succinyl-CoA but fully relies on the lipoyl residues provided by AceF involved in the reactions to convert pyruvate to acetyl-CoA
-
-
?
additional information
?
-
-
OdhA can utilize free dihydrodilipoamide to perform the E2 reaction specifically with succinyl-CoA. OdhA specifically catalyzes the E1 and E2 reaction to convert 2-oxoglutarate to succinyl-CoA but fully relies on the lipoyl residues provided by AceF involved in the reactions to convert pyruvate to acetyl-CoA
-
-
?
additional information
?
-
-
enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview
-
-
?
additional information
?
-
-
enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview
-
-
?
additional information
?
-
-
the E1o component of the2-oxoglutarate dehydrogenase complex catalyses the initial, substrate-specific and irreversible stage of the overall reaction, and has the lowest catalytic activity (turnover number) among the components and as such limits the rate of the overall process
-
-
?
additional information
?
-
-
enzyme also catalyzes the production of H2O2 from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a target for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview
-
-
?
additional information
?
-
no substrates: pyruvic acid, benzoylformic acid, 2-oxopentanoic acid, 4-methyl-2-oxopentanoic acid and 3-methyl-2-oxobutanoic acid. The enzyme additionally displays low acetolactate synthase activity
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