1.4.1.8: valine dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about valine dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
dehydrogenase, valine (nicotinamide adenine dinucleotide phosphate), ValDH, valine dehydrogenase (nicotinamide adenine dinucleotide phosphate), VDH
ECTree
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Engineering
Engineering on EC 1.4.1.8 - valine dehydrogenase (NADP+)
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A124G
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lower activity toward aliphatic amino acid substrates, e.g. catalytic rate constant for oxidative deamination of L-valine is only 12% of the wild type, but higher activities toward L-phenylalanine, L-tyrosine, and L-methionine
K79A
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lower affinity for L-valine and 2-oxoisovalerate and lower catalytic rate constants compared to the wild type enzyme
K91A
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lower affinity for L-valine and 2-oxoisovalerate and lower catalytic rate constants compared to the wild type enzyme
additional information
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active site lysine residue modified with pyridoxal 5-phosphate