1.5.1.53: methylenetetrahydrofolate reductase (NADPH) This is an abbreviated version! For detailed information about methylenetetrahydrofolate reductase (NADPH), go to the full flat file .
Reaction
5-methyltetrahydrofolate +
NADP+ =
5,10-methylenetetrahydrofolate +
NADPH +
H+
Synonyms 5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, MET13, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase (NADPH2), methylenetetrahydrofolic acid reductase, MTHFR, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 1.5.1.53 - methylenetetrahydrofolate reductase (NADPH)
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5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
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5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
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5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
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5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
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5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
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enzyme is specific for the (+) diastereoisomer of 5,10-methylenetetrahydrofolate as its physiological substrate. In addition, the enzyme exhibits a strong NADPH-specific diaphorase (reduced-NAD:lipoamide oxidoreductase, EC 1.8.1.4) or menadione reductase (reduced-NAD(P):(acceptor) oxidoreductase, EC 1.6.5.2 ) activity
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no substrate: dihydrofolate
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