1.5.1.B5: DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)
This is an abbreviated version!
For detailed information about DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH), go to the full flat file.
Word Map on EC 1.5.1.B5
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1.5.1.B5
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sulfatases
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mucopolysaccharidosis
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formylglycine-generating
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metachromatic
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sulfatase-modifying
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leukodystrophy
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ichthyosis
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formylglycine
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aav-mediated
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x-linked
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co-delivery
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intracerebral
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infantile
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autosomal-recessive
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ataxia
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mpsiiia
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adeno-associated
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posttranslationally
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sulfamidase
- 1.5.1.B5
-
sulfatases
-
mucopolysaccharidosis
-
formylglycine-generating
-
metachromatic
-
sulfatase-modifying
-
leukodystrophy
-
ichthyosis
-
formylglycine
-
aav-mediated
-
x-linked
-
co-delivery
-
intracerebral
-
infantile
-
autosomal-recessive
-
ataxia
-
mpsiiia
-
adeno-associated
-
posttranslationally
-
sulfamidase
Reaction
Synonyms
DELTA-pyrroline-2-carboxylate reductase, DELTA1-pyrroline-2-carboxylate reductase, NADH-dependent Pyr2C reductase, Pyr2C reductase, TlLhpI, tlPyr2C
ECTree
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Cofactor
Cofactor on EC 1.5.1.B5 - DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)
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additional information
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the preference of tlPyr2C for NADH instead of NADPH can be rationalized by analysing the residues of tlPyr2C that bind to the 2'-hydroxyl group of NADH and comparing them with the residues of tlPyr2C orthologues that bind to the phosphate group of NADPH. Determination and analysis of the NADH binding structure and interaction network of tlPyr2C, structure comparisons, detailed overview. A role of Asn168 in the selectivity for NADH versus NADPH is suggested
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NAD+
H3ZMH3; H3ZMH4
the kcat/Km value for proline in the presence of NADP+ is about 50fold lower than that in the presence of NAD+