1.5.1.B5: DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)
This is an abbreviated version!
For detailed information about DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH), go to the full flat file.
Word Map on EC 1.5.1.B5
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1.5.1.B5
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sulfatases
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mucopolysaccharidosis
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formylglycine-generating
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metachromatic
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sulfatase-modifying
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leukodystrophy
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ichthyosis
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formylglycine
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aav-mediated
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x-linked
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co-delivery
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intracerebral
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infantile
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autosomal-recessive
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ataxia
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mpsiiia
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adeno-associated
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posttranslationally
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sulfamidase
- 1.5.1.B5
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sulfatases
-
mucopolysaccharidosis
-
formylglycine-generating
-
metachromatic
-
sulfatase-modifying
-
leukodystrophy
-
ichthyosis
-
formylglycine
-
aav-mediated
-
x-linked
-
co-delivery
-
intracerebral
-
infantile
-
autosomal-recessive
-
ataxia
-
mpsiiia
-
adeno-associated
-
posttranslationally
-
sulfamidase
Reaction
Synonyms
DELTA-pyrroline-2-carboxylate reductase, DELTA1-pyrroline-2-carboxylate reductase, NADH-dependent Pyr2C reductase, Pyr2C reductase, TlLhpI, tlPyr2C
ECTree
1.5.1.B5 DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)Advanced search results
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Reaction
Reaction on EC 1.5.1.B5 - DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)
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REACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
L-pipecolate + NAD+ = DELTA1-piperideine-2-carboxylate + NADH + H+
(1)
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L-pipecolate + NAD+ = DELTA1-piperideine-2-carboxylate + NADH + H+
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L-proline + NAD+ = DELTA1-pyrroline-2-carboxylate + NADH + H+
catalytic mechanism, overview. The hydride ion is transferred from the C4 atom of NADH to the C2 atom of Pyr2C, causing electron transfer to the vicinal N atom of Pyr2C, which is now capable of accepting the proton donated by the guanidine group of Arg43. The product L-proline forms a hydrogen bond to the carbonyl O atom of Val301, which stabilizes formation of the product prior to its release. Lys71 and Arg114 are highly conserved and are involved in substrate binding through their interaction with the substrate carboxyl group. But the NH2 group of the guanidine of Arg43 engages in a hydrogen bond to the close carbonyl O atom of Val301 and to the distant N atom of the substrate, the putative proton acceptor of the catalytic reaction
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L-proline + NAD+ = DELTA1-pyrroline-2-carboxylate + NADH + H+
catalytic mechanism, overview. The hydride ion is transferred from the C4 atom of NADH to the C2 atom of Pyr2C, causing electron transfer to the vicinal N atom of Pyr2C, which is now capable of accepting the proton donated by the guanidine group of Arg43. The product L-proline forms a hydrogen bond to the carbonyl O atom of Val301, which stabilizes formation of the product prior to its release. Lys71 and Arg114 are highly conserved and are involved in substrate binding through their interaction with the substrate carboxyl group. But the NH2 group of the guanidine of Arg43 engages in a hydrogen bond to the close carbonyl O atom of Val301 and to the distant N atom of the substrate, the putative proton acceptor of the catalytic reaction
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L-proline + NAD+ = DELTA1-pyrroline-2-carboxylate + NADH + H+
catalytic mechanism, overview. The hydride ion is transferred from the C4 atom of NADH to the C2 atom of Pyr2C, causing electron transfer to the vicinal N atom of Pyr2C, which is now capable of accepting the proton donated by the guanidine group of Arg43. The product L-proline forms a hydrogen bond to the carbonyl O atom of Val301, which stabilizes formation of the product prior to its release. Lys71 and Arg114 are highly conserved and are involved in substrate binding through their interaction with the substrate carboxyl group. But the NH2 group of the guanidine of Arg43 engages in a hydrogen bond to the close carbonyl O atom of Val301 and to the distant N atom of the substrate, the putative proton acceptor of the catalytic reaction
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L-proline + NAD+ = DELTA1-pyrroline-2-carboxylate + NADH + H+
(2)
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L-proline + NAD+ = DELTA1-pyrroline-2-carboxylate + NADH + H+
catalytic mechanism, overview. The hydride ion is transferred from the C4 atom of NADH to the C2 atom of Pyr2C, causing electron transfer to the vicinal N atom of Pyr2C, which is now capable of accepting the proton donated by the guanidine group of Arg43. The product L-proline forms a hydrogen bond to the carbonyl O atom of Val301, which stabilizes formation of the product prior to its release. Lys71 and Arg114 are highly conserved and are involved in substrate binding through their interaction with the substrate carboxyl group. But the NH2 group of the guanidine of Arg43 engages in a hydrogen bond to the close carbonyl O atom of Val301 and to the distant N atom of the substrate, the putative proton acceptor of the catalytic reaction
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L-proline + NAD+ = DELTA1-pyrroline-2-carboxylate + NADH + H+
catalytic mechanism, overview. The hydride ion is transferred from the C4 atom of NADH to the C2 atom of Pyr2C, causing electron transfer to the vicinal N atom of Pyr2C, which is now capable of accepting the proton donated by the guanidine group of Arg43. The product L-proline forms a hydrogen bond to the carbonyl O atom of Val301, which stabilizes formation of the product prior to its release. Lys71 and Arg114 are highly conserved and are involved in substrate binding through their interaction with the substrate carboxyl group. But the NH2 group of the guanidine of Arg43 engages in a hydrogen bond to the close carbonyl O atom of Val301 and to the distant N atom of the substrate, the putative proton acceptor of the catalytic reaction
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L-proline + NAD+ = DELTA1-pyrroline-2-carboxylate + NADH + H+
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