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1.7.1.9: nitroquinoline-N-oxide reductase

This is an abbreviated version!
For detailed information about nitroquinoline-N-oxide reductase, go to the full flat file.

Reaction

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4-(hydroxyamino)quinoline N-oxide
+ 2 NAD(P)+ +
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H2O
=
Show molfile
4-Nitroquinoline N-oxide
+ 2 NAD(P)H + 2 H+

Synonyms

4-nitroquinoline 1-oxide reductase, 4NQO reductase, EC 1.6.6.10, NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.1 With NAD+ or NADP+ as acceptor
                EC 1.7.1.91.7.1.9 nitroquinoline-N-oxide reductase

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Resultsin table
1CAS Registry Number
3Inhibitors
1KM Value [mM]
2Localization
1Molecular Weight [Da]
10Organism
1Purification (Commentary)
2Reaction
3Reaction Type
10Reference
12Specific Activity [micromol/min/mg]
10Substrates and Products (Substrate)
4Synonyms
1Systematic Name
All data fields related to EC 1.7.1.9

Reference

Reference on EC 1.7.1.9 - nitroquinoline-N-oxide reductase

for references in articles please use BRENDA:EC1.7.1.9

Please use the Reference Search for a specific query.

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Suzuki, K.
Distribution of 4-nitroquinoline 1-oxide reductase in the mucosa of canine digestive tract
Gann
69
229-235
1978
Canis lupus familiaris
Manually annotated by BRENDA team
Booth, D.R.
A relationship found between intra-oral sites of 4NQO reductase activity and chemical carcinogenesis
Cell Tissue Kinet.
23
331-340
1990
Rattus norvegicus
Manually annotated by BRENDA team
Suzuki, K.
The distribution of 4-nitroquinoline 1-oxide reductase in the mucosa of animal digestive tracts
Nihon Univ. J. Med.
20
345-357
1978
Cavia porcellus, Cricetinae, Felis catus, Oryctolagus cuniculus, Rattus norvegicus
-
Manually annotated by BRENDA team
Stanley, J.S.; York, J.L.; Benson, a.M.
Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice
Cancer Res.
52
58-63
1992
Mus musculus
Manually annotated by BRENDA team
Benson, A.M.
Conversion of 4-nitroquinoline 1-oxide (4NQO) to 4-hydroxyaminoquinoline 1-oxide by a dicumarol-resistant hepatic 4NQO nitroreductase in rats and mice
Biochem. Pharmacol.
46
1217-1221
1993
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team