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1.8.3.7: formylglycine-generating enzyme

This is an abbreviated version!
For detailed information about formylglycine-generating enzyme, go to the full flat file.

Word Map on EC 1.8.3.7

Reaction

a [sulfatase]-L-cysteine
+
O2
 + 2 a thiol =
a [sulfatase]-3-oxo-L-alanine
 +
hydrogen sulfide
 +
a disulfide
 +
H2O

Synonyms

AtsB, C-alpha-formylglycine-generating enzyme 1, Calpha-formylglycine-generating enzyme, Calpha-formylglycine-generating enzyme 1, FGE, FGly-generating enzyme, formylglycine generating enzyme, sulfatase-modifying factor 1, SUMF1

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.3 With oxygen as acceptor
                1.8.3.7 formylglycine-generating enzyme

Crystallization

Crystallization on EC 1.8.3.7 - formylglycine-generating enzyme

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with bromide and iodide ions, using 20-25% (w/v) PEG 4000, 0.1 M Tris-HCl pH 8.0-9.0, 0.2-0.3 M CaCl2
using 20-25% (w/v) PEG 4000/0.1 M Tris-HCl, pH 8.0-9.0, 0.2-0.3 M CaCl2
vapor diffusion method, using 100 mM Tris, 2.4 M ammonium formate, 0.3% (w/v) beta-octylglucoside, 3.2% (v/v) 2-butanol, pH 8.0
-
X-ray crystal structure of Cu-bound enzyme at a resolution of 2.2 A
1.04 A structure of the enzyme in complex with copper and a cysteine-containing peptide substrate (Abz-ATTPLCGPSRASILSGR)
in complex with in complex with either Ag+ or Cd2+
-