1.8.3.7: formylglycine-generating enzyme
This is an abbreviated version!
For detailed information about formylglycine-generating enzyme, go to the full flat file.
Word Map on EC 1.8.3.7
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1.8.3.7
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sulfatases
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metachromatic
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mucopolysaccharidosis
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leukodystrophy
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ichthyosis
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antibody-drug
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ultra-rare
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morquio
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medicine
- 1.8.3.7
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sulfatases
-
metachromatic
- mucopolysaccharidosis
- leukodystrophy
-
ichthyosis
-
antibody-drug
-
ultra-rare
- morquio
- medicine
Reaction
Synonyms
AtsB, C-alpha-formylglycine-generating enzyme 1, Calpha-formylglycine-generating enzyme, Calpha-formylglycine-generating enzyme 1, FGE, FGly-generating enzyme, formylglycine generating enzyme, sulfatase-modifying factor 1, SUMF1
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Inhibitors
Inhibitors on EC 1.8.3.7 - formylglycine-generating enzyme
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the substrate specificity for the cysteine motifs CTPS is not changed upon addition of the cofactor copper
Cu2+
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Cu2+-treated enzyme converts both cysteine motifs (CTPSR and CTAGR)
Cu2+
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Cu2+-treated enzyme converts both cysteine motifs (CTPSR and CTAGR)
proprotein convertases like furin, PACE4, and PC5a process and thereby inactivate formylglycine-generating enzyme
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additional information
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proprotein convertases like furin, PACE4, and PC5a process and thereby inactivate formylglycine-generating enzyme
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