1.8.98.2: sulfiredoxin
This is an abbreviated version!
For detailed information about sulfiredoxin, go to the full flat file.
Word Map on EC 1.8.98.2
-
1.8.98.2
-
peroxiredoxins
-
hyperoxidation
-
thioredoxins
-
overoxidized
-
sulfenic
-
peroxidatic
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txnrd1
-
sulfinylated
-
deglutathionylation
-
prxiii
-
prdxs
-
cys-so2h
-
medicine
-
drug development
- 1.8.98.2
- peroxiredoxins
-
hyperoxidation
- thioredoxins
-
overoxidized
-
sulfenic
-
peroxidatic
- txnrd1
-
sulfinylated
-
deglutathionylation
-
prxiii
-
prdxs
-
cys-so2h
- medicine
- drug development
Reaction
Synonyms
AtSrx, cysteine-sulfinic acid reductase, neoplastic progression 3, peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase, protein cysteine sulfinic acid reductase, Srx, Srx1, Srxn1, sulfiredoxin, sulfiredoxin 1, sulfiredoxin-1, sulphiredoxin
ECTree
1.8.98.2 sulfiredoxinAdvanced search results
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topReference on EC 1.8.98.2 - sulfiredoxin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jönsson, T.J.; Murray, M.S.; Johnson, L.C.; Poole, L.B.; Lowther, W.T.
Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin
Biochemistry
44
8634-8642
2005
Homo sapiens (Q9BYN0), Homo sapiens
Findlay, V.J.; Tapiero, H.; Townsend, D.M.
Sulfiredoxin: a potential therapeutic agent?
Biomed. Pharmacother.
59
374-379
2005
Homo sapiens
Chang, T.S.; Jeong, W.; Woo, H.A.; Lee, S.M.; Park, S.; Rhee, S.G.
Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine
J. Biol. Chem.
279
50994-51001
2004
Homo sapiens, Mus musculus, Rattus norvegicus
Woo, H.A.; Jeong, W.; Chang, T.S.; Park, K.J.; Park, S.J.; Yang, J.S.; Rhee, S.G.
Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-Cys peroxiredoxins
J. Biol. Chem.
280
3125-3128
2005
Rattus norvegicus
Biteau, B.; Labarre, J.; Toledano, M.B.
ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin
Nature
425
980-984
2003
Saccharomyces cerevisiae
Lee, D.Y.; Park, S.J.; Jeong, W.; Sung, H.J.; Oho, T.; Wu, X.; Rhee, S.G.; Gruschus, J.M.
Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysis
Biochemistry
45
15301-15309
2006
Homo sapiens (Q9BYN0), Homo sapiens
Findlay, V.J.; Townsend, D.M.; Morris, T.E.; Fraser, J.P.; He, L.; Tew, K.D.
A novel role for human sulfiredoxin in the reversal of glutathionylation
Cancer Res.
66
6800-6806
2006
Homo sapiens (Q9BYN0), Homo sapiens
Liu, X.P.; Liu, X.Y.; Zhang, J.; Xia, Z.L.; Liu, X.; Qin, H.J.; Wang, D.W.
Molecular and functional characterization of sulfiredoxin homologs from higher plants
Cell Res.
16
287-296
2006
Arabidopsis thaliana (Q8GY89), Oryza sativa
Jeong, W.; Park, S.J.; Chang, T.S.; Lee, D.Y.; Rhee, S.G.
Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin
J. Biol. Chem.
281
14400-14407
2006
Homo sapiens
Jang, H.H.; Chi, Y.H.; Park, S.K.; Lee, S.S.; Lee, J.R.; Park, J.H.; Moon, J.C.; Lee, Y.M.; Kim, S.Y.; Lee, K.O.; Lee, S.Y.
Structural and functional regulation of eukaryotic 2-Cys peroxiredoxins including the plant ones in cellular defense-signaling mechanisms against oxidative stress
Physiol. Plant.
126
549-559
2006
Saccharomyces cerevisiae, Homo sapiens
Rey, P.; Becuwe, N.; Barrault, M.B.; Rumeau, D.; Havaux, M.; Biteau, B.; Toledano, M.B.
The Arabidopsis thaliana sulfiredoxin is a plastidic cysteine-sulfinic acid reductase involved in the photooxidative stress response
Plant J.
49
505-514
2007
Arabidopsis thaliana, Arabidopsis thaliana (Q8GY89)
Roussel, X.; Bechade, G.; Kriznik, A.; Van Dorsselaer, A.; Sanglier-Cianferani, S.; Branlant, G.; Rahuel-Clermont, S.
Evidence for the formation of a covalent thiosulfinate intermediate with peroxiredoxin in the catalytic mechanism of sulfiredoxin
J. Biol. Chem.
283
22371-22382
2008
Saccharomyces cerevisiae
Joensson, T.J.; Tsang, A.W.; Lowther, W.T.; Furdui, C.M.
Identification of intact protein thiosulfinate intermediate in the reduction of cysteine sulfinic acid in peroxiredoxin by human sulfiredoxin
J. Biol. Chem.
283
22890-22894
2008
Homo sapiens (Q9BYN0), Homo sapiens
Soriano, F.X.; Leveille, F.; Papadia, S.; Higgins, L.G.; Varley, J.; Baxter, P.; Hayes, J.D.; Hardingham, G.E.
Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione
J. Neurochem.
107
533-543
2008
Rattus norvegicus
Joensson, T.J.; Johnson, L.C.; Lowther, W.T.
Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace
Nature
451
98-101
2008
Homo sapiens (Q9BYN0), Homo sapiens
Kim, H.; Kim, H.; Hong, S.; Rhee, S.G.; Jeong, W.
A colorimetric assay for sulfiredoxin activity using inorganic phosphate measurement
Anal. Biochem.
393
36-40
2009
Homo sapiens
Singh, A.; Ling, G.; Suhasini, A.N.; Zhang, P.; Yamamoto, M.; Navas-Acien, A.; Cosgrove, G.; Tuder, R.M.; Kensler, T.W.; Watson, W.H.; Biswal, S.
Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs
Free Radic. Biol. Med.
46
376-386
2009
Homo sapiens, Mus musculus
Park, J.W.; Mieyal, J.J.; Rhee, S.G.; Chock, P.B.
Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin
J. Biol. Chem.
284
23364-23374
2009
Homo sapiens
Roussel, X.; Kriznik, A.; Richard, C.; Rahuel-Clermont, S.; Branlant, G.
The catalytic mechanism of Sulfiredoxin from Saccharomyces cerevisiae passes through an oxidized disulfide Sulfiredoxin intermediate that is reduced by thioredoxin
J. Biol. Chem.
284
33048-33055
2009
Saccharomyces cerevisiae
Noh, Y.H.; Baek, J.Y.; Jeong, W.; Rhee, S.G.; Chang, T.S.
Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III
J. Biol. Chem.
284
8470-8477
2009
Homo sapiens
Lei, K.; Townsend, D.M.; Tew, K.D.
Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response
Oncogene
27
4877-4887
2008
Homo sapiens
Iglesias-Baena, I.; Barranco-Medina, S.; Lazaro-Payo, A.; Lopez-Jaramillo, F.J.; Sevilla, F.; Lazaro, J.J.
Characterization of plant sulfiredoxin and role of sulphinic form of 2-Cys peroxiredoxin
J. Exp. Bot.
61
1509-1521
2010
Arabidopsis thaliana, Arabidopsis thaliana Columbia
Moon, J.C.; Kim, G.M.; Kim, E.K.; Lee, H.N.; Ha, B.; Lee, S.Y.; Jang, H.H.
Reversal of 2-Cys peroxiredoxin oligomerization by sulfiredoxin
Biochem. Biophys. Res. Commun.
432
291-295
2013
Saccharomyces cerevisiae
Roussel, X.; Boukhenouna, S.; Rahuel-Clermont, S.; Branlant, G.
The rate-limiting step of sulfiredoxin is associated with the transfer of the gamma-phosphate of ATP to the sulfinic acid of overoxidized typical 2-Cys peroxiredoxins
FEBS Lett.
585
574-578
2011
Saccharomyces cerevisiae
Chi, Y.H.; Kim, S.Y.; Jung, I.J.; Shin, M.R.; Jung, Y.J.; Park, J.H.; Lee, E.S.; Maibam, P.; Kim, K.S.; Park, J.H.; Kim, M.J.; Hwang, G.Y.; Lee, S.Y.
Dual functions of Arabidopsis sulfiredoxin: acting as a redox-dependent sulfinic acid reductase and as a redox-independent nuclease enzyme
FEBS Lett.
586
3493-3499
2012
Arabidopsis thaliana
Baek, J.Y.; Han, S.H.; Sung, S.H.; Lee, H.E.; Kim, Y.M.; Noh, Y.H.; Bae, S.H.; Rhee, S.G.; Chang, T.S.
Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2
J. Biol. Chem.
287
81-89
2012
Mus musculus (Q9D975), Mus musculus
Iglesias-Baena, I.; Barranco-Medina, S.; Sevilla, F.; Lazaro, J.J.
The dual-targeted plant sulfiredoxin retroreduces the sulfinic form of atypical mitochondrial peroxiredoxin
Plant Physiol.
155
944-955
2011
Arabidopsis thaliana (Q8GY89), Pisum sativum (D2KKL9), Pisum sativum
Shi, S.; Guo, Y.; Lou, Y.; Li, Q.; Cai, X.; Zhong, X.; Li, H.
Sulfiredoxin involved in the protection of peroxiredoxins against hyperoxidation in the early hyperglycaemia
Exp. Cell Res.
352
273-280
2017
Rattus norvegicus
Rhee, S.G.; Kil, I.S.
Mitochondrial H2O2 signaling is controlled by the concerted action of peroxiredoxin III and sulfiredoxin Linking mitochondrial function to circadian rhythm
Free Radic. Biol. Med.
99
120-127
2016
Mus musculus
Calderon, A.; Lazaro-Payo, A.; Iglesias-Baena, I.; Camejo, D.; Lazaro, J.J.; Sevilla, F.; Jimenez, A.
Glutathionylation of pea chloroplast 2-Cys Prx and mitochondrial Prx IIF affects their structure and peroxidase activity and sulfiredoxin deglutathionylates only the 2-Cys Prx
Front. Plant Sci.
8
118
2017
Pisum sativum
Sevilla, F.; Camejo, D.; Ortiz-Espin, A.; Calderon, A.; Lazaro, J.J.; Jimenez, A.
The thioredoxin/peroxiredoxin/sulfiredoxin system current overview on its redox function in plants and regulation by reactive oxygen and nitrogen species
J. Exp. Bot.
66
2945-2955
2015
Arabidopsis thaliana
Li, Q.; Yu, S.; Wu, J.; Zou, Y.; Zhao, Y.
Sulfiredoxin-1 protects PC12 cells against oxidative stress induced by hydrogen peroxide
J. Neurosci. Res.
91
861-870
2013
Rattus norvegicus
Kil, I.S.; Bae, S.H.; Rhee, S.G.
Study of the signaling function of sulfiredoxin and peroxiredoxin III in isolated adrenal gland unsuitability of clonal and primary adrenocortical cells
Methods Enzymol.
527
169-181
2013
Mus musculus
Forshaw, T.E.; Reisz, J.A.; Nelson, K.J.; Gumpena, R.; Lawson, J.R.; Joensson, T.J.; Wu, H.; Clodfelter, J.E.; Johnson, L.C.; Furdui, C.M.; Lowther, W.T.
Specificity of human sulfiredoxin for reductant and peroxiredoxin oligomeric state
Antioxidants (Basel)
10
946
2021
Homo sapiens (Q9BYN0), Homo sapiens
Liu, M.; Wang, J.; Li, X.; Sylvanno, M.J.; Li, M.; Zhang, M.; Wang, M.
The crystal structure of sulfiredoxin from Arabidopsis thaliana revealed a more robust antioxidant mechanism in plants
Biochem. Biophys. Res. Commun.
520
347-352
2019
Arabidopsis thaliana (Q8GY89), Arabidopsis thaliana
Chawsheen, H.A.; Jiang, H.; Ying, Q.; Ding, N.; Thapa, P.; Wei, Q.
The redox regulator sulfiredoxin forms a complex with thioredoxin domain-containing 5 protein in response to ER stress in lung cancer cells
J. Biol. Chem.
294
8991-9006
2019
Homo sapiens (Q9BYN0), Homo sapiens
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