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ADP-linked PEP carboxykinase
ATP, oxaloacetate carboxy-lyase (transphosphorylating)
-
-
ATP-dependent phosphoenolpyruvate carboxykinase
ATP-dependent phosphoenolpyruvate(PEP)carboxykinase
ATP-forming PEP-carboxykinase
ATP-oxaloacetate carboxylase (transphosporylating)
ATP: oxaloacetate carboxy-lyase
-
ATP:oxaloacetate carboxy-lyase
transphosphorylating, interacts also with GTP, EC 4.1.1.32
ATP:oxaloacetate carboxylyase (transphosphorylating)
-
Carboxykinase, phosphopyruvate (adenosine triphosphate)
-
-
-
-
Glycosomal protein P60
-
-
-
-
PEP carboxylase kinase
-
-
PEPC kinase
PPCK1 and PPCK2 genes
phosphoenolpyruvate carboxykinase
phosphoenolpyruvate carboxykinase ATP-dependent
-
-
phosphoenolpyruvate carboxykinase [ATP]
-
-
Phosphoenolpyruvate carboxylase
Phosphoenolpyruvate carboxylase (ATP)
-
-
-
-
phosphoenolpyruvate carboxylase kinase
-
phosphoenolpyruvate(PEP)carboxykinase (GTP/ATP:oxaloacetate carboxy-lyase (transphosphorylating)EC 4.1.1.32/49)
phosphoenolpyruvic carboxykinase
-
-
-
-
Phosphoenolpyruvic carboxylase
-
-
-
-
phosphopyruvate carboxykinase
-
-
-
-
Phosphopyruvate carboxykinase (adenosine triphosphate)
-
-
-
-
yeast PEP carboxykinase
-
-
ADP-linked PEP carboxykinase

-
-
ADP-linked PEP carboxykinase
-
-
-
ADP-linked PEP carboxykinase
-
-
ATP-dependent phosphoenolpyruvate carboxykinase

-
-
ATP-dependent phosphoenolpyruvate carboxykinase
-
-
ATP-dependent phosphoenolpyruvate(PEP)carboxykinase

-
-
ATP-dependent phosphoenolpyruvate(PEP)carboxykinase
-
-
ATP-dependent phosphoenolpyruvate(PEP)carboxykinase
-
-
ATP-forming PEP-carboxykinase

-
-
ATP-forming PEP-carboxykinase
-
-
-
ATP-oxaloacetate carboxylase (transphosporylating)

-
-
ATP-oxaloacetate carboxylase (transphosporylating)
-
-
ATP-oxaloacetate carboxylase (transphosporylating)
-
-
PCK

-
-
pckA

-
-
PEP carboxykinase

-
-
-
-
PEP carboxylase

-
-
-
-
PEPC

-
-
PEPC
Alternanthera ficoides
-
-
PEPCK

-
-
-
-
PEPCK
Anaerobiospirillum succiniproducens
-
-
PEPCK
no activity in Hordeum vulgare
-
-
phosphoenolpyruvate carboxykinase

-
-
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
Alternanthera ficoides
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
phosphoenolpyruvate carboxykinase
Anaerobiospirillum succiniproducens
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
no activity in Hordeum vulgare
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
phosphoenolpyruvate carboxykinase
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
phosphoenolpyruvate carboxykinase
-
-
Phosphoenolpyruvate carboxylase

-
-
-
-
Phosphoenolpyruvate carboxylase
-
-
phosphoenolpyruvate(PEP)carboxykinase (GTP/ATP:oxaloacetate carboxy-lyase (transphosphorylating)EC 4.1.1.32/49)

-
-
phosphoenolpyruvate(PEP)carboxykinase (GTP/ATP:oxaloacetate carboxy-lyase (transphosphorylating)EC 4.1.1.32/49)
-
-
phosphoenolpyruvate(PEP)carboxykinase (GTP/ATP:oxaloacetate carboxy-lyase (transphosphorylating)EC 4.1.1.32/49)
-
-
PPC

-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ADP + (E)-3-fluorophosphoenolpyruvate + CO2
ATP + 3-fluorooxaloacetate
ADP + (Z)-3-fluorophosphoenolpyruvate + CO2
ATP + 3-fluorooxaloacetate
ADP + phosphoenolpyruvate + CO2
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
ATP + aspartate
ADP + alanine + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
ATP + phosphoenolpyruvate + CO2
ADP + oxaloacetate
CTP + oxaloacetate
CDP + phosphoenolpyruvate + CO2
-
15% of the activity with ATP
-
-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
ITP + oxaloacetate
IDP + phosphoenolpyruvate + CO2
TTP + oxaloacetate
TDP + phosphoenolpyruvate + CO2
-
16% of the activity with ATP
-
-
?
UTP + oxaloacetate
UDP + phosphoenolpyruvate + CO2
-
20% of the activity with ATP
-
-
?
additional information
?
-
ADP + (E)-3-fluorophosphoenolpyruvate + CO2

ATP + 3-fluorooxaloacetate
-
-
-
?
ADP + (E)-3-fluorophosphoenolpyruvate + CO2
ATP + 3-fluorooxaloacetate
-
-
-
?
ADP + (Z)-3-fluorophosphoenolpyruvate + CO2

ATP + 3-fluorooxaloacetate
-
-
-
?
ADP + (Z)-3-fluorophosphoenolpyruvate + CO2
ATP + 3-fluorooxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2

?
-
catabolic CO2-fixing enzyme, important role in succinate formation
-
-
?
ADP + phosphoenolpyruvate + CO2
?
-
the enzyme is responsible for the CO2 fixation
-
-
?
ADP + phosphoenolpyruvate + CO2

ATP + oxaloacetate
-
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
in contrast to its normal role in gluconeogenesis, PEP carboxykinase can operate in the reverse direction from phosphoenolpyruvate to oxaloacetate, upon knockout of pyruvate kinase in a riboflavin-producing Bacillus subtilis strain and in wild-type 168
-
-
r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
the enzyme may function in the conversion of carbon skeletons to phosphoenolpyruvate, which, depending on the energy requirements of the phloem, is subsequently utilised by either gluconoeogenesis or the Krebs cycle, which both consume protons
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
synthesis of oxaloacetate is a key step in the formation of four-carbon compounds, such as malate, fumarate, and succinate
-
r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
-
r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
Arg70 is important for catalytic efficiency of the enzyme and for binding of phosphoenolpyruvate
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ATP + oxaloacetate

?
-
the enzyme is neither regulatory nor inducible, the main function is catalyzing the synthesis of phosphoenopyruvate as a part of the gluconeogenetic pathway
-
-
?
ATP + oxaloacetate
?
-
the enzyme is neither regulatory nor inducible, the main function is catalyzing the synthesis of phosphoenopyruvate as a part of the gluconeogenetic pathway
-
-
?
ATP + oxaloacetate

ADP + phosphoenolpyruvate + CO2
-
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
Alternanthera ficoides
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
for the Anaerobiospirillum succiniciproducens enzyme, at physiological concentrations of Mn2+ and Mg2+, the affinity for CO2 increases as the ATP/ADP ratio is increased in the assay medium. The results show that a high ATP/ADP ratio favors CO2 fixation by the PEP carboxykinase from Anaerobiospirillum succiniciproducens
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
Anaerobiospirillum succiniproducens
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
Anaerobiospirillum succiniproducens
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
key enzyme in the regulation of flux through the gluconeogenic pathway, gluconeogenic production of sugars from storage oil
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
first commmitted step of gluconeogenesis
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates towards gluconeogenesis
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
first commmitted step of gluconeogenesis
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
responsible for light-independent carbon fixation
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
ADP is the preferred PCK phosphate acceptor
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
ADP is the preferred PCK phosphate acceptor
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
interacts also with GTP, EC 4.1.1.32
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
acts in the metabolic pathways at the intersection of the glycolysis, the gluconeogenesis and the Krebs cycle, enzyme activity increases when cells are submitted to hypothermic stress
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
responsible for light-independent carbon fixation
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
first commmitted step of gluconeogenesis
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + phosphoenolpyruvate + CO2

ADP + oxaloacetate
-
-
-
-
?
ATP + phosphoenolpyruvate + CO2
ADP + oxaloacetate
-
-
-
-
?
GTP + oxaloacetate

GDP + phosphoenolpyruvate + CO2
when ADP is replaced by GDP in the PEP-carboxylating reaction, PCK activity decreases approximately 5fold
-
-
r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
when ADP is replaced by GDP in the PEP-carboxylating reaction, PCK activity decreases approximately 5fold
-
-
r
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
52% of the activity with ATP
-
-
?
GTP + oxaloacetate
GDP + phosphoenolpyruvate + CO2
-
52% of the activity with ATP
-
-
?
ITP + oxaloacetate

IDP + phosphoenolpyruvate + CO2
-
36% of the activity with ATP
-
-
?
ITP + oxaloacetate
IDP + phosphoenolpyruvate + CO2
-
36% of the activity with ATP
-
-
?
additional information

?
-
-
no activity with IDP, GDP, ITP and GTP
-
-
?
additional information
?
-
-
catalyzes an exchange reaction between C14O2 and the beta-carboxyl group of oxaloacetate
-
-
?
additional information
?
-
-
catalyzes an exchange reaction between C14O2 and the beta-carboxyl group of oxaloacetate
-
-
?
additional information
?
-
-
PEP carboxykinase utilizes 2'-dADP and 2'-dATP as substrates with kinetic and equilibrium dissociation constants very similar to those of ADP and ATP, respectively
-
-
?
additional information
?
-
GDP and IDP are no substrates
-
?
additional information
?
-
GDP and IDP are no substrates
-
?
additional information
?
-
-
under physiological conditions the enzyme is bidirectional and is regulated primarily by mass action
-
-
?
additional information
?
-
-
CO2-exchange reaction with ATP, GTP, ITP, CTP, UTP and TTP
-
-
?
additional information
?
-
-
central role in energy metabolism
-
-
?
additional information
?
-
-
important regulatory function of the enzyme in the amino-acid catabolism of Trypanosoma cruzi
-
-
?
additional information
?
-
-
important regulatory function of the enzyme in the amino-acid catabolism of Trypanosoma cruzi
-
-
?
additional information
?
-
-
CO2-exchange reaction with ATP, GTP, ITP, CTP, UTP and TTP
-
-
?
additional information
?
-
-
decarboxylation of aspartate is dependent on the activity of PEPCK
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ADP + phosphoenolpyruvate + CO2
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
ATP + phosphoenolpyruvate + CO2
ADP + oxaloacetate
additional information
?
-
ADP + phosphoenolpyruvate + CO2

?
-
catabolic CO2-fixing enzyme, important role in succinate formation
-
-
?
ADP + phosphoenolpyruvate + CO2
?
-
the enzyme is responsible for the CO2 fixation
-
-
?
ADP + phosphoenolpyruvate + CO2

ATP + oxaloacetate
-
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
in contrast to its normal role in gluconeogenesis, PEP carboxykinase can operate in the reverse direction from phosphoenolpyruvate to oxaloacetate, upon knockout of pyruvate kinase in a riboflavin-producing Bacillus subtilis strain and in wild-type 168
-
-
r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
synthesis of oxaloacetate is a key step in the formation of four-carbon compounds, such as malate, fumarate, and succinate
-
r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
-
-
?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
-
-
r
ATP + oxaloacetate

?
-
the enzyme is neither regulatory nor inducible, the main function is catalyzing the synthesis of phosphoenopyruvate as a part of the gluconeogenetic pathway
-
-
?
ATP + oxaloacetate
?
-
the enzyme is neither regulatory nor inducible, the main function is catalyzing the synthesis of phosphoenopyruvate as a part of the gluconeogenetic pathway
-
-
?
ATP + oxaloacetate

ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
Alternanthera ficoides
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
Anaerobiospirillum succiniproducens
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
key enzyme in the regulation of flux through the gluconeogenic pathway, gluconeogenic production of sugars from storage oil
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
first commmitted step of gluconeogenesis
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates towards gluconeogenesis
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
first commmitted step of gluconeogenesis
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
responsible for light-independent carbon fixation
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
acts in the metabolic pathways at the intersection of the glycolysis, the gluconeogenesis and the Krebs cycle, enzyme activity increases when cells are submitted to hypothermic stress
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
responsible for light-independent carbon fixation
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
first commmitted step of gluconeogenesis
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
carbon and nitrogen metabolism
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
?
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
-
-
r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
-
gluconeogenesis and anaplerotic reactions
-
r
ATP + phosphoenolpyruvate + CO2

ADP + oxaloacetate
-
-
-
-
?
ATP + phosphoenolpyruvate + CO2
ADP + oxaloacetate
-
-
-
-
?
additional information

?
-
-
under physiological conditions the enzyme is bidirectional and is regulated primarily by mass action
-
-
?
additional information
?
-
-
central role in energy metabolism
-
-
?
additional information
?
-
-
important regulatory function of the enzyme in the amino-acid catabolism of Trypanosoma cruzi
-
-
?
additional information
?
-
-
important regulatory function of the enzyme in the amino-acid catabolism of Trypanosoma cruzi
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(NH4)2SO4
-
10 mM, slight
2,3-Butanedione
-
phosphoenolpyruvate, ADP and Mn2+, alone or in combination protect against inactivation
5,5'-dithiobis(2-nitrobenzoate)
-
-
D-fructose 1,6-bisphosphate
dihydroxyacetone phosphate
Fluorescein mercuric acetate
fructose 1,6-bisphosphate
-
-
IDP
-
inhibits exchange reaction with ATP or GTP
iodoacetamide
-
less than 10% inhibition
MnCl2
-
excess ogf MnCl2 over ATP is inhibitory
NEM
-
less than 10% inhibition
o-Iodobenzoate
-
0.2 mM , 50% inhibition
o-Iodosobenzoate
-
0.5 mM, 50% inhibition
p-chloromercuribenzenesulfonate
Phenylglyoxal
-
phosphoenolpyruvate, ADP and Mn2+, alone or in combination protect against inactivation. Modification of only two of the three to four reactive arginine residues per enzyme subunit is responsible for inactivation
quinolinic acid
-
1 mM, complete inhibition of decarboxylation
3-Mercaptopicolinic acid

-
specific to this enzyme
3-Mercaptopicolinic acid
-
-
ATP

the presence of 9.6 mM ATP decreases 3folds the catalytic efficiency of the enzyme
ATP
-
excess of ATP over MnCl2 is inhibitory
ATP
transcription of pck gene is suppressed by
ATP
-
5 mM, inhibition of carboxylation
D-fructose 1,6-bisphosphate

Anaerobiospirillum succiniproducens
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
-
D-fructose 6-phosphate

Anaerobiospirillum succiniproducens
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
dihydroxyacetone phosphate

Anaerobiospirillum succiniproducens
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
dihydroxyacetone phosphate
-
-
Fluorescein mercuric acetate

-
0.0008 mM, 50% inhibition
Fluorescein mercuric acetate
-
-
Glycerate 3-phosphate

Anaerobiospirillum succiniproducens
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
Glycerate 3-phosphate
-
-
malate

-
-
malate
Alternanthera ficoides
-
-
Mg2+

Anaerobiospirillum succiniproducens
-
-
oxalate

-
competitive inhibitor
oxalate
-
competitive inhibitor
oxalate
-
competitive inhibitor
p-chloromercuribenzenesulfonate

-
0.0025 mM, 50% inhibition
p-chloromercuribenzenesulfonate
-
-
p-chloromercuribenzoate

-
-
p-chloromercuribenzoate
-
0.007 mM, 50% inhibition
p-chloromercuribenzoate
-
-
additional information

presence of inorganic phosphate strongly reduces expression of PPCK1 and PPCK2 transcripts
-
additional information
-
presence of inorganic phosphate strongly reduces expression of PPCK1 and PPCK2 transcripts
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acidosis
The regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat kidney cortex. The role of acid-base balance and glucocorticoids.
Acidosis, Lactic
Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Cause of Hypoglycemia-Induced Seizure and Death.
Adenoviridae Infections
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Carcinoma, Hepatocellular
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Carcinoma, Hepatocellular
Effects of amino acid analogues on protein synthesis and degradation in isolated cells.
Carcinoma, Hepatocellular
Regulation of gene expression in rat hepatocytes and hepatoma cells by insulin: quantitation of messenger ribonucleic acid's coding for tyrosine aminotransferase, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase.
Carcinoma, Hepatocellular
Regulation of phosphoenolpyruvate carboxykinase gene transcription by insulin and cAMP: reciprocal actions on initiation and elongation.
Carcinoma, Hepatocellular
The role of protein synthesis in the decay of phosphoenolpyruvate carboxykinase messenger RNA.
Carcinoma, Hepatocellular
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Chagas Disease
Crystal structure of the dimeric phosphoenolpyruvate carboxykinase (PEPCK) from Trypanosoma cruzi at 2 A resolution.
Dehydration
[Activity of NADP-dependent glyceraldehyde-phosphate dehydrogenase and phosphoenolpyruvate carboxylase in wheat leaves under water stress]
Herpes Simplex
A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection.
Hyperglycemia
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
Hyperthyroidism
3,5,3'-Triiodothyronine-induced synthesis of rat liver phosphoenolpyruvate carboxykinase.
Hyperthyroidism
Renal phosphoenolpyruvate carboxykinase turnover in hypo- and hyperthyroid rat in vivo.
Hypoglycemia
Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Cause of Hypoglycemia-Induced Seizure and Death.
Infections
A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection.
Infections
Cell-surface location of Listeria-specific protein p60--detection of Listeria cells by indirect immunofluorescence.
Insulinoma
Identification of a calcium-regulated insulinoma cell phosphoprotein as an islet cell keratin.
Liver Neoplasms
Hepatic gluconeogenic key enzymes in patients with hepatic cancer.
Neoplasms
Autoimmune expression of a cytoplasmic protein p60 in mice bearing metastasizing SV40-transformed tumors.
Neoplasms
Identification of transformation-specific proteins synthesized in cryptovirogenic mammalian cells.
Neoplasms
The Mechanism by Which Amentoflavone Improves Insulin Resistance in HepG2 Cells.
Neurodegenerative Diseases
G Proteins, p60TRP, and Neurodegenerative Diseases.
Sarcoma, Avian
Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60.
Starvation
3,5,3'-Triiodothyronine-induced synthesis of rat liver phosphoenolpyruvate carboxykinase.
Starvation
cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei.
Starvation
Characterization and functional analysis of phosphoenolpyruvate carboxylase kinase genes in rice.
Starvation
Induction of rat liver phosphoenolpyruvate carbonxykinase (GTP) by cyclic AMP during starvation. The permissive action of glucocorticoids.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0059 - 0.0085
(Z)-3-fluorophosphoenolpyruvate
0.035 - 8
phosphoenolpyruvate
additional information
additional information
MnATP2- as substrate, for S252A mutant Km above 3000 microM
-
0.0059
(Z)-3-fluorophosphoenolpyruvate

-
0.0085
(Z)-3-fluorophosphoenolpyruvate
-
0.01
ADP

-
mutant enzyme E299A, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.013
ADP
-
mutant enzyme Y207L, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.016
ADP
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.017
ADP
-
ADP in form of MnADP-
0.032
ADP
-
pH 6.5, 30°C, mutant enzyme H225E
0.034
ADP
-
pH 6.6, 30°C, wild-type enzyme
0.034
ADP
-
kinetic parameter in the PEP carboxylation direction
0.034
ADP
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.034
ADP
-
ADP in form of MnADP-
0.034
ADP
ADP in form of MnADP-
0.039
ADP
-
ADP in form of MgADP-
0.04
ADP
ADP in form of MnADP-
0.043
ADP
-
pH 6.5, 30°C, mutant enzyme D263E
0.058
ADP
-
pH 6.6, 30°C, mutant enzyme R70K
0.063
ADP
-
pH 6.6, 30°C, mutant enzyme R70Q
0.075
ADP
-
ADP in form of MnADP-
0.077
ADP
-
pH 6.5, 30°C, wild-type enzyme
0.077
ADP
for the pyruvate kinase-like activity of S252A mutant
0.077
ADP
ADP in form of MnADP-
0.086
ADP
-
pH 6.6, 30°C, mutant enzyme R70M
0.09
ADP
wild-type, pH 7.4, 37°C
0.099
ADP
-
mutant enzyme L460A, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.1
ADP
mutant Y180F, pH 7.4, 37°C
0.132
ADP
ADP in form of MnADP-
0.151
ADP
for the pyruvate kinase-like activity of wild-type
0.151
ADP
ADP in form of MnADP-
0.17
ADP
-
F216Y: kinetic parameter in the PEP carboxylation direction
0.17
ADP
-
ADP in form of MnADP-
0.29
ADP
mutant Y180A, pH 7.4, 37°C
0.41
ADP
mutant H205Q, pH 7.4, 37°C
0.81
ADP
in 50 mM HEPES (pH 7.0)
2.03
ADP
for R457M mutant
2.03
ADP
ADP in form of MnADP-
17
ADP
-
pH 7.0, 25°C, 5 mM Mn2+, 4 mM Mg2+
18
ADP
-
pH 7.0, 25°C, 5 mM Mn2+, 4 mM Mg2+
36
ADP
-
pH 7.0, 25°C, 0.010 mM Mn2+, 4 mM Mg2+, light
44
ADP
-
pH 7.0, 25°C, 0.010 mM Mn2+, 4 mM Mg2+, dark
0.0011
ATP

-
pH 7.0, 25°C, 5 mM Mn2+, 4 mM Mg2+
0.0015
ATP
-
pH 7.0, 25°C, 5 mM Mn2+
0.016
ATP
-
F216Y: kinetic parameter in the PEP formation direction
0.016
ATP
-
ATP in form of MnATP2-
0.019
ATP
-
exchange reaction
0.019
ATP
-
ATP in form of MnATP2-
0.0257
ATP
-
pH 7.0, 25°C, 0.010 mM Mn2+, 4 mM Mg2+, light
0.026
ATP
-
mutant enzyme E299A, in 100 mM MOPS buffer (pH 7.0), at 30°C
0.027
ATP
-
ATP in form of MnATP2-
0.03
ATP
-
wild type enzyme, in 100 mM MOPS buffer (pH 7.0), at 30°C
0.034
ATP
-
kinetic parameter in the PEP formation direction
0.034
ATP
-
ATP in form of MnATP2-
0.0435
ATP
-
pH 7.0, 25°C, 0.010 mM Mn2+, 4 mM Mg2+, dark
0.054
ATP
wild-type, pH 7.4, 37°C
0.067
ATP
ATP in form of MnATP2-
0.09
ATP
mutant Y180A, pH 7.4, 37°C
0.09
ATP
mutant Y180F, pH 7.4, 37°C
0.15
ATP
mutant H205Q, pH 7.4, 37°C
0.204
ATP
-
mutant enzyme L460A, in 100 mM MOPS buffer (pH 7.0), at 30°C
1.83
ATP
in 50 mM HEPES (pH 7.0)
0.009
CO2

for wild-type
0.009
CO2
CO2 in form of HCO3-
0.0098
CO2
for R457M mutant
0.0098
CO2
CO2 in form of HCO3-
0.01
CO2
-
pH 6.6, 30°C, mutant enzyme R70M
0.01
CO2
-
CO2 in form of HCO3-
0.018
CO2
-
pH 6.6, 30°C, wild-type enzyme
0.018
CO2
-
kinetic parameter in the PEP carboxylation direction
0.018
CO2
-
CO2 in form of HCO3-
0.019
CO2
-
pH 6.6, 30°C, mutant enzyme R70Q
0.019
CO2
-
CO2 in form of HCO3-
0.024
CO2
-
F216Y: kinetic parameter in the PEP carboxylation direction
0.024
CO2
-
CO2 in form of HCO3-
0.025
CO2
-
pH 6.6, 30°C, mutant enzyme R70K
0.025
CO2
-
CO2 in form of HCO3-
0.03
CO2
-
pH 6.5, 30°C, mutant enzyme D263E
0.03
CO2
-
CO2 in form of HCO3-
0.033
CO2
-
pH 6.5, 30°C, wild-type enzyme
0.033
CO2
-
CO2 in form of HCO3-
0.036
CO2
-
pH 6.5, 30°C, mutant enzyme H225E
0.036
CO2
-
CO2 in form of HCO3-
0.055
CO2
-
pH 7.0, 25°C, 0.010 mM Mn2+, 4 mM Mg2+, light and dark
0.238
CO2
-
pH 7.0, 25°C, 5 mM Mn2+, 4 mMM Mg2+
0.36
CO2
-
condition: 0.1 mM Mn2+, 5 mM Mg2 /Vmax: 16 micromol/min/mg
0.732
CO2
-
pH 7.0, 25°C, 5 mM Mn2+
1.9
CO2
-
condition: 0.1 mM Mn2+, 5 mM Mg2 /Vmax: 37 micromol/min/mg
2
CO2
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
2 - 3
CO2
-
mutant enzyme K212M, in 100 mM MOPS buffer (pH 6.6), at 30°C
2.77
CO2
-
CO2 in form of NaHCO3
3.1
CO2
-
condition: 4 mM Mn2+ /Vmax: 60 micromol/min/mg
3.7
CO2
-
CO2 in form of HCO3-
5
CO2
-
CO2 in form of HCO3-
8.4
CO2
-
condition: 4 mM Mn2+ /Vmax: 47 micromol/min/mg
9
CO2
-
mutant enzyme E272Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
11
CO2
-
mutant enzyme K213Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
13
CO2
-
CO2 in form of HCO3-
14
CO2
-
mutant enzyme E284Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
14
CO2
-
mutant enzyme L460A, in 100 mM MOPS buffer (pH 6.6), at 30°C
17
CO2
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
17
CO2
-
CO2 in form of HCO3-
17
CO2
-
CO2 in form of HCO3-
18
CO2
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
18
CO2
-
CO2 in form of HCO3-
18
CO2
CO2 in form of HCO3-
26
CO2
-
CO2 in form of HCO3-
29
CO2
-
mutant enzyme Y207L, in 100 mM MOPS buffer (pH 6.6), at 30°C
47
CO2
-
mutant enzyme E299A, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.01
Mn2+

-
kinetic parameter in the PEP formation direction
0.012
Mn2+
-
pH high (pH range:6-8.4), pH:12, PEP carboxylation direction
0.023
Mn2+
-
kinetic parameter in the PEP carboxylation direction
0.056
Mn2+
-
F216Y: kinetic parameter in the PEP carboxylation direction
0.063
Mn2+
-
mutant F216Y
0.123
Mn2+
-
pH low (pH range:6-8.4), PEP carboxylation direction
0.345
Mn2+
-
F216Y: kinetic parameter in the PEP formation direction
0.066
oxalacetate

-
kinetic parameter in the PEP formation direction
0.122
oxalacetate
for the oxaloacetate decarboxylase activity of wild-type
1.079
oxalacetate
-
F216Y: kinetic parameter in the PEP formation direction
5.2
oxalacetate
for the oxaloacetate decarboxylase activity of S252A mutant
0.014
oxaloacetate

-
condition: + 2 mM ADP /Vmax: 0.32 micromol/min/mg
0.024
oxaloacetate
-
mutant enzyme K213Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.026
oxaloacetate
S252A mutant
0.03
oxaloacetate
wild-type
0.041
oxaloacetate
-
exchange reaction
0.051
oxaloacetate
-
mutant enzyme L460A, in 100 mM MOPS buffer (pH 7.0), at 30°C
0.066
oxaloacetate
-
wild type enzyme, in 100 mM MOPS buffer (pH 7.0), at 30°C
0.068
oxaloacetate
-
mutant enzyme K212M, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.079
oxaloacetate
-
condition: no ADP /Vmax: 3.27 micromol/min/mg
0.085
oxaloacetate
-
pH 7.0, 25°C, 5 mM Mn2+
0.09
oxaloacetate
wild-type, pH 7.4, 37°C
0.1
oxaloacetate
-
pH 7.0, 25°C, 5 mM Mn2+, 4 mM Mg2+
0.13
oxaloacetate
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.13
oxaloacetate
-
mutant enzyme E299A, in 100 mM MOPS buffer (pH 7.0), at 30°C
0.156
oxaloacetate
-
pH 7.0, 25°C, 0.010 mM Mn2+, 4 mM Mg2+, light
0.17
oxaloacetate
mutant Y180F, pH 7.4, 37°C
0.2
oxaloacetate
-
mutant enzyme K212R, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.21
oxaloacetate
mutant H205Q, pH 7.4, 37°C
0.238
oxaloacetate
-
mutant enzyme E272Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.304
oxaloacetate
-
pH 7.0, 25°C, 0.010 mM Mn2+, 4 mM Mg2+, dark
0.43
oxaloacetate
-
condition: no ADP /Vmax: 1.51 micromol/min/mg
0.43
oxaloacetate
mutant Y180A, pH 7.4, 37°C
0.99
oxaloacetate
-
condition: + 2 mM ADP /Vmax: 3.36 micromol/min/mg
1.81
oxaloacetate
in 50 mM HEPES (pH 7.0)
2
oxaloacetate
-
Km above 2.0 mM, mutant enzyme E284Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.035
phosphoenolpyruvate

-
-
0.037
phosphoenolpyruvate
for the pyruvate kinase-like activity of S252A mutant
0.04
phosphoenolpyruvate
-
-
0.05
phosphoenolpyruvate
-
pH 7.3, 37°C, 0.05 mM bicarbonate
0.06
phosphoenolpyruvate
at pH 7.0 and 37°C
0.07
phosphoenolpyruvate
-
-
0.07
phosphoenolpyruvate
-
pH 7.3, 37°C, 10 mM bicarbonate
0.082
phosphoenolpyruvate
S252A mutant
0.083
phosphoenolpyruvate
-
0.085
phosphoenolpyruvate
-
pH 6.5, 30°C, mutant enzyme H225E
0.104
phosphoenolpyruvate
-
mutant enzyme L460A, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.108
phosphoenolpyruvate
-
mutant enzyme E299A, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.11
phosphoenolpyruvate
Alternanthera ficoides
-
pH 7.3, 37°C, 0.05 mM bicarbonate
0.135
phosphoenolpyruvate
for the pyruvate kinase-like activity of wild-type
0.15
phosphoenolpyruvate
-
pH 7.3, 37°C, 0.05 mM bicarbonate
0.17
phosphoenolpyruvate
-
mutant enzyme E284Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.185
phosphoenolpyruvate
-
mutant enzyme E272Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.2
phosphoenolpyruvate
Alternanthera ficoides
-
pH 7.3, 37°C, 10 mM bicarbonate
0.216
phosphoenolpyruvate
-
mutant enzyme K212M, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.219
phosphoenolpyruvate
-
pH 6.5, 30°C, wild-type enzyme
0.28
phosphoenolpyruvate
-
pH 7.3, 37°C, 0.05 mM bicarbonate
0.289
phosphoenolpyruvate
-
pH 6.5, 30°C, mutant enzyme D263E
0.29
phosphoenolpyruvate
-
pH 7.3, 37°C, 10 mM bicarbonate
0.3
phosphoenolpyruvate
for R457M mutant
0.307
phosphoenolpyruvate
-
-
0.307
phosphoenolpyruvate
wild-type
0.307
phosphoenolpyruvate
-
pH 6.6, 30°C, wild-type enzyme
0.307
phosphoenolpyruvate
-
kinetic parameter in the PEP carboxylation direction
0.307
phosphoenolpyruvate
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.31
phosphoenolpyruvate
for wild-type
0.32
phosphoenolpyruvate
-
mutant enzyme K213Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.323
phosphoenolpyruvate
-
mutant F216Y
0.36
phosphoenolpyruvate
-
-
0.402
phosphoenolpyruvate
-
0.41
phosphoenolpyruvate
-
pH 6.6, 30°C, mutant enzyme R70K
0.49
phosphoenolpyruvate
-
-
0.5
phosphoenolpyruvate
-
in presence of Mn2+
0.5
phosphoenolpyruvate
-
mutant enzyme Y207L, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.52
phosphoenolpyruvate
in 50 mM HEPES (pH 7.0)
0.54
phosphoenolpyruvate
-
-
0.55
phosphoenolpyruvate
pH 7.0, 37°C
0.59
phosphoenolpyruvate
mutant Y180F, pH 7.4, 37°C
0.62
phosphoenolpyruvate
-
pH 7.3, 37°C, 10 mM bicarbonate
0.651
phosphoenolpyruvate
-
mutant enzyme K212R, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.72
phosphoenolpyruvate
-
pH 6.6, 30°C, mutant enzyme R70Q
0.73
phosphoenolpyruvate
-
pH 6.6, 30°C, mutant enzyme R70M
0.9
phosphoenolpyruvate
wild-type, pH 7.4, 37°C
0.917
phosphoenolpyruvate
-
F216Y: kinetic parameter in the PEP carboxylation direction
1.24
phosphoenolpyruvate
mutant Y180A, pH 7.4, 37°C
1.38
phosphoenolpyruvate
-
pH 7.0, 25°C, 5 mM Mn2+
1.63
phosphoenolpyruvate
mutant H205Q, pH 7.4, 37°C
1.67
phosphoenolpyruvate
-
pH 7.0, 25°C, 5 mM Mn2+, 4 mM Mg2+
2.1
phosphoenolpyruvate
-
pH 7.0, 25°C, 0.010 mM Mn2+, 4 mM Mg2+, light
2.65
phosphoenolpyruvate
-
pH 7.0, 25°C, 0.010 mM Mn2+, 4 mM Mg2+, dark
3
phosphoenolpyruvate
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
8
phosphoenolpyruvate
-
in presence of Mg2+
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.33 - 1.1
(Z)-3-fluorophosphoenolpyruvate
0.08 - 51.54
oxaloacetate
0.014 - 65.52
phosphoenolpyruvate
additional information
additional information
kcat for oxalacetate as a substrate is above 19 1/s for S252A mutant in the phosphoenolpyruvate formation direction
-
0.33
(Z)-3-fluorophosphoenolpyruvate

-
1.1
(Z)-3-fluorophosphoenolpyruvate
-
0.67
ADP

mutant H205Q, pH 7.4, 37°C
3.22
ADP
mutant Y180A, pH 7.4, 37°C
13
ADP
-
mutant enzyme L460A, in 100 mM MOPS buffer (pH 6.6), at 30°C
18
ADP
-
mutant enzyme E299A, in 100 mM MOPS buffer (pH 6.6), at 30°C
29.8
ADP
mutant Y180F, pH 7.4, 37°C
62
ADP
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
78.82
ADP
wild-type, pH 7.4, 37°C
3 - 6
ATP

-
mutant enzyme L460A, in 100 mM MOPS buffer (pH 7.0), at 30°C
3.86
ATP
mutant H205Q, pH 7.4, 37°C
3.93
ATP
mutant Y180A, pH 7.4, 37°C
6.75
ATP
mutant Y180F, pH 7.4, 37°C
32
ATP
-
mutant enzyme E299A, in 100 mM MOPS buffer (pH 7.0), at 30°C
38
ATP
-
wild type enzyme, in 100 mM MOPS buffer (pH 7.0), at 30°C
48.09
ATP
wild-type, pH 7.4, 37°C
0.32
oxalacetate

for the oxaloacetate decarboxylase activity of wild-type
1
oxalacetate
for the oxaloacetate decarboxylase activity of S252A mutant
65
oxalacetate
wild-type, apparent kinetic parameters for wild-type in the phosphoenolpyruvate formation direction
0.08
oxaloacetate

-
Km above 2.0 mM, mutant enzyme E284Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.08
oxaloacetate
-
mutant enzyme E272Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.11
oxaloacetate
-
mutant enzyme K212R, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.28
oxaloacetate
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.58
oxaloacetate
-
mutant enzyme K213Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.85
oxaloacetate
-
mutant enzyme K212M, in 100 mM MOPS buffer (pH 6.6), at 30°C
3.18
oxaloacetate
mutant Y180A, pH 7.4, 37°C
4.41
oxaloacetate
mutant H205Q, pH 7.4, 37°C
9.07
oxaloacetate
mutant Y180F, pH 7.4, 37°C
51.54
oxaloacetate
wild-type, pH 7.4, 37°C
0.014
phosphoenolpyruvate

-
mutant enzyme K212R, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.07
phosphoenolpyruvate
-
mutant enzyme E284Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.13
phosphoenolpyruvate
-
mutant enzyme K212M, in 100 mM MOPS buffer (pH 6.6), at 30°C
0.2
phosphoenolpyruvate
for the pyruvate kinase-like activity of S252A mutant
0.5
phosphoenolpyruvate
S252A mutant, apparent kinetic parameters for S252A mutant in the phosphoenolpyruvate carboxylation direction
0.67
phosphoenolpyruvate
at pH 7.0 and 37°C
0.7
phosphoenolpyruvate
mutant H205Q, pH 7.4, 37°C
0.8
phosphoenolpyruvate
for the pyruvate kinase-like activity of wild-type
2.66
phosphoenolpyruvate
mutant Y180A, pH 7.4, 37°C
3 - 6
phosphoenolpyruvate
for wild-type
5.1
phosphoenolpyruvate
-
mutant enzyme K213Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
9.67
phosphoenolpyruvate
-
-
13
phosphoenolpyruvate
for R457M mutant
19
phosphoenolpyruvate
-
mutant enzyme E272Q, in 100 mM MOPS buffer (pH 6.6), at 30°C
37.78
phosphoenolpyruvate
mutant Y180F, pH 7.4, 37°C
62
phosphoenolpyruvate
wild-type, apparent kinetic parameters for wild-type in the phosphoenolpyruvate carboxylation direction
63
phosphoenolpyruvate
-
wild type enzyme, in 100 mM MOPS buffer (pH 6.6), at 30°C
65.52
phosphoenolpyruvate
wild-type, pH 7.4, 37°C
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