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Information on EC 4.1.1.49 - phosphoenolpyruvate carboxykinase (ATP)
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4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)Specify your search results
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The enzyme appears in viruses and cellular organisms
Synonyms
pepc kinase, protein p60, phosphoenolpyruvate carboxylase kinase, pepk, atp-dependent phosphoenolpyruvate carboxykinase, pep carboxylase kinase, osppck3, pfpepck, osppck1, pepck (atp), 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ADP-linked PEP carboxykinase
ATP-dependent phosphoenolpyruvate carboxykinase
ATP-dependent phosphoenolpyruvate(PEP)carboxykinase
ATP-forming PEP-carboxykinase
ATP-oxaloacetate carboxylase (transphosphorylating)
ATP:oxaloacetate carboxy-lyase
transphosphorylating, interacts also with GTP, EC 4.1.1.32
Carboxykinase, phosphopyruvate (adenosine triphosphate)
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Glycosomal protein P60
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PCK
pckA
PEP carboxykinase
PEP carboxylase
PEPC
PEPCK
PEPCK (ATP)
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PEPK
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phosphoenolpyruvate carboxykinase
Phosphoenolpyruvate carboxylase
Phosphoenolpyruvate carboxylase (ATP)
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phosphoenolpyruvate(PEP)carboxykinase (GTP/ATP:oxaloacetate carboxy-lyase (transphosphorylating)EC 4.1.1.32/49)
phosphoenolpyruvic carboxykinase
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Phosphoenolpyruvic carboxylase
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phosphopyruvate carboxykinase
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Phosphopyruvate carboxykinase (adenosine triphosphate)
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PPC
Protein p60
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PEP carboxykinase
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PEP carboxykinase
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PEP carboxylase
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PEPCK
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phosphoenolpyruvate carboxykinase
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phosphoenolpyruvate carboxykinase
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Phosphoenolpyruvate carboxylase
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phosphoenolpyruvate(PEP)carboxykinase (GTP/ATP:oxaloacetate carboxy-lyase (transphosphorylating)EC 4.1.1.32/49)
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phosphoenolpyruvate(PEP)carboxykinase (GTP/ATP:oxaloacetate carboxy-lyase (transphosphorylating)EC 4.1.1.32/49)
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phosphoenolpyruvate(PEP)carboxykinase (GTP/ATP:oxaloacetate carboxy-lyase (transphosphorylating)EC 4.1.1.32/49)
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
carboxylation
decarboxylation
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)
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CAS REGISTRY NUMBER
COMMENTARY
9073-94-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + oxaloacetate
CDP + phosphoenolpyruvate + CO2
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15% of the activity with ATP
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?
TTP + oxaloacetate
TDP + phosphoenolpyruvate + CO2
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16% of the activity with ATP
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?
UTP + oxaloacetate
UDP + phosphoenolpyruvate + CO2
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20% of the activity with ATP
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?
ADP + (E)-3-fluorophosphoenolpyruvate + CO2
ATP + 3-fluorooxaloacetate
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?
ADP + (E)-3-fluorophosphoenolpyruvate + CO2
ATP + 3-fluorooxaloacetate
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?
ADP + (Z)-3-fluorophosphoenolpyruvate + CO2
ATP + 3-fluorooxaloacetate
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?
ADP + (Z)-3-fluorophosphoenolpyruvate + CO2
ATP + 3-fluorooxaloacetate
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?
ADP + phosphoenolpyruvate + CO2
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catabolic CO2-fixing enzyme, important role in succinate formation
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?
ADP + phosphoenolpyruvate + CO2
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the enzyme is responsible for the CO2 fixation
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?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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in contrast to its normal role in gluconeogenesis, PEP carboxykinase can operate in the reverse direction from phosphoenolpyruvate to oxaloacetate, upon knockout of pyruvate kinase in a riboflavin-producing Bacillus subtilis strain and in wild-type 168
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r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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the enzyme may function in the conversion of carbon skeletons to phosphoenolpyruvate, which, depending on the energy requirements of the phloem, is subsequently utilised by either gluconoeogenesis or the Krebs cycle, which both consume protons
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?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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synthesis of oxaloacetate is a key step in the formation of four-carbon compounds, such as malate, fumarate, and succinate
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r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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Arg70 is important for catalytic efficiency of the enzyme and for binding of phosphoenolpyruvate
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?
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
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r
ADP + phosphoenolpyruvate + CO2
ATP + oxaloacetate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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ATP + oxaloacetate
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the enzyme is neither regulatory nor inducible, the main function is catalyzing the synthesis of phosphoenopyruvate as a part of the gluconeogenetic pathway
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?
ATP + oxaloacetate
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Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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the enzyme is neither regulatory nor inducible, the main function is catalyzing the synthesis of phosphoenopyruvate as a part of the gluconeogenetic pathway
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ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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for the Anaerobiospirillum succiniciproducens enzyme, at physiological concentrations of Mn2+ and Mg2+, the affinity for CO2 increases as the ATP/ADP ratio is increased in the assay medium. The results show that a high ATP/ADP ratio favors CO2 fixation by the PEP carboxykinase from Anaerobiospirillum succiniciproducens
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
Anaerobiospirillum succiniproducens
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
Anaerobiospirillum succiniproducens
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gluconeogenesis and anaplerotic reactions
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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gluconeogenesis and anaplerotic reactions
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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key enzyme in the regulation of flux through the gluconeogenic pathway, gluconeogenic production of sugars from storage oil
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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gluconeogenesis and anaplerotic reactions
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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gluconeogenesis and anaplerotic reactions
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
Coleus scutellarioides
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gluconeogenesis and anaplerotic reactions
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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first commmitted step of gluconeogenesis
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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gluconeogenesis and anaplerotic reactions
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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carbon and nitrogen metabolism
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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gluconeogenesis and anaplerotic reactions
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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gluconeogenesis and anaplerotic reactions
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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gluconeogenesis and anaplerotic reactions
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ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates towards gluconeogenesis
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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first commmitted step of gluconeogenesis
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ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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gluconeogenesis and anaplerotic reactions
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ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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carbon and nitrogen metabolism
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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responsible for light-independent carbon fixation
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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carbon and nitrogen metabolism
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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gluconeogenesis and anaplerotic reactions
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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carbon and nitrogen metabolism
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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carbon and nitrogen metabolism
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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carbon and nitrogen metabolism
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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gluconeogenesis and anaplerotic reactions
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r
ATP + oxaloacetate
ADP + phosphoenolpyruvate + CO2
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ADP is the preferred PCK phosphate acceptor