2.3.3.13: 2-isopropylmalate synthase

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For detailed information about 2-isopropylmalate synthase, go to the full flat file.

Reaction

Synonyms

2-isopropylmalate synthase 1, chloroplastic, 2-isopropylmalate synthase 2, chloroplastic, 3-hydroxy-4-methyl-3-carboxy-pentanoate 2-oxo-3-methyl-butanoate lyase (CoA-acetylating), 3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methyl-butyrate lyase (CoA-acetylating), alpha-IPM synthase, Alpha-IPM synthetase, alpha-IPMS, alpha-IPMS-14CR, alpha-IPMS-2CR, Alpha-isopropylmalate synthase, alpha-isopropylmalate synthase I, alpha-isopropylmalate synthase II, alpha-isopropylmalate synthetase, alpha-isopropylmalic synthetase, BatIMS, EC 4.1.3.12, IPM synthase, IPM-synthase, IPMS, IPMS1, IPMS2, IPMS3, isopropylmalate synthase, isopropylmalate synthase 1, isopropylmalate synthetase, LEU4, LEU9, leuA, Mj1195, MtalphaIPMS, MtIPMS, NmeIPMS, Os11g04670, Os12g04440, OsIPMS1, OsIPMS2, ROL17, synthase, 2-isopropylmalate, synthase, alpha-isopropylmalate, TT_C0849

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.3 Acyl groups converted into alkyl groups on transfer

                2.3.3.13 2-isopropylmalate synthase

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Results	in table
1	Activating Compound
38019	AA Sequence
11	Application
1	CAS Registry Number
24	Cloned(Commentary)
3	Cofactor
5	Crystallization (Commentary)
3	Expression
15	General Information
1	General Stability
1	IC50 Value
112	Inhibitors
15	kcat/KM [mM/s]
46	Ki Value [mM]
116	KM Value [mM]
12	Localization
46	Metals/Ions
31	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
589	Organism
8	Pathway
22	PDB ID
25	pH Optimum
3	pH Range
8	pH Stability
1	Posttranslational Modification
50	Protein Variants
27	Purification (Commentary)
2	Reaction
9	Reaction Type
116	Reference
1	Renatured (Commentary)
20	Source Tissue
15	Specific Activity [micromol/min/mg]
8	Storage Stability
224	Substrates and Products (Substrate)
23	Subunits
116	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Range [°C]
11	Temperature Stability [°C]
75	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 2.3.3.13 - 2-isopropylmalate synthase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

acetylation

Thermus thermophilus

Q72JC9

the enzyme is acetylated at four lysine residues. It is acetylated non-enzymatically by acetyl-CoA and deacetylated enzymatically by TT_C0104. Acetylation mimicking mutations at Lys332 markedly decreases enzyme activity in vitro, suggesting that Lys332, which is located in subdomain II, plays a regulatory role in activity

756685