2.4.1.255: protein O-GlcNAc transferase
This is an abbreviated version!
For detailed information about protein O-GlcNAc transferase, go to the full flat file.
Word Map on EC 2.4.1.255
Reaction
Synonyms
beta-N-acetylglucosaminidase, EGF domain-specific O-GlcNAc transferase, EGF domain-specific O-linked N-acetylglucosamine transferase, EOGT, EOGT1, epidermal growth factor domain-specific O-GlcNAc transferase, glycosyltransferase OGT, Gtf1, GtfA, hOGT, HsOGT, human OGT, mammalian OGT, mOGT, More, N-acetylglucosamine transferase, N-acetylglucosamine-peptide N-acetylglucosaminyltransferase, N-acetylglucosaminyltransferase, ncOGT, nuclear cytoplasmic OGT, nucleocytoplasmic glycosyltransferase, nucleocytoplasmic OGT, O-GlcNAc protein, O-GlcNAc transferase, O-GlcNAc transferase OGT, O-GlcNAc-transferase, O-GlcNAcase, O-glycosylated protein p135, O-linked beta-N-acetylglucosamine transferase, O-linked beta-N-acetylglucosaminyltransferase, O-linked GlcNAc transferase, O-linked N-acetylglucosamine transferase, O-linked N-acetylglucosaminyltransferase, O-N-acetylglucosamine (O-GlcNAc) transferase, OGT, OGT p110, OGT protein, ogta, OGTase, OGTase protein, ogtb, p135, Protein SECRET AGENT, SEC, SECRET AGENT, sOGT, spindly, SPY, super sex combs, Sxc, Synpcc7942_0051, transferase OGT, UDP-GlcNAc: polypeptide O-N-acetylglucosaminyltransferase, UDP-GlcNAc:polypeptidyl transferase, UDP-N-acetylglucosaminyl transferase, uridine diphosphate-N-acetyl-D-glucosamine:polypeptidyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylaminyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase, XcOGT, XcOGT protein
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Reference on EC 2.4.1.255 - protein O-GlcNAc transferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Haltiwanger, R.S.; Blomberg, M.A.; Hart, G.W.
Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase
J. Biol. Chem.
267
9005-9013
1992
Rattus norvegicus
Kreppel, L.K.; Blomberg, M.A.; Hart, G.W.
Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats
J. Biol. Chem.
272
9308-9315
1997
Rattus norvegicus (P56558)
Roos, M.D.; Hanover, J.A.
Structure of O-linked GlcNAc transferase: Mediator of glycan-dependent signaling
Biochem. Biophys. Res. Commun.
271
275-280
2000
Arabidopsis thaliana, Homo sapiens, no activity in Saccharomyces cerevisiae, no activity in Escherichia coli, Rhodobacter sp.
Lubas, W.A.; Hanover, J.A.
Functional expression of O-linked GlcNAc transferase: domain structure and substrate specificity
J. Biol. Chem.
275
10983-10988
2000
Homo sapiens
Konrad, R.J.; Tolar, J.F.; Hale, J.E.; Knierman, M.D.; Becker, G.W.; Kudlow, J.E.
Purification of the O-glycosylated protein p135 and identification as O-GlcNAc transferase
Biochem. Biophys. Res. Commun.
288
1136-1140
2001
Rattus norvegicus
Andrali, S.S.; Marz, P.; Ozcan, S.
Ataxin-10 interacts with O-GlcNAc transferase OGT in pancreatic beta cells
Biochem. Biophys. Res. Commun.
337
149-153
2005
Homo sapiens
Akimoto, Y.; Comer, F.I.; Cole, R.N.; Kudo, A.; Kawakami, H.; Hirano, H.; Hart, G.W.
Localization of the O-GlcNAc transferase and O-GlcNAc-modified proteins in rat cerebellar cortex
Brain Res.
966
194-205
2003
Rattus norvegicus
Zachara, N.E.; O'Donnell, N.; Cheung, W.D.; Mercer, J.J.; Marth, J.D.; Hart, G.W.
Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress: A survival response of mammalian cells
J. Biol. Chem.
279
30133-30142
2004
Chlorocebus aethiops
Wells, L.; Kreppel, L.K.; Comer, F.I.; Wadzinski, B.E.; Hart, G.W.
O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits
J. Biol. Chem.
279
38466-38470
2004
Rattus norvegicus
Lazarus, B.D.; Roos, M.D.; Hanover, J.A.
Mutational analysis of the catalytic domain of O-linked N-acetylglucosaminyl transferase
J. Biol. Chem.
280
35537-35544
2005
Homo sapiens
Chen, D.; Juarez, S.; Hartweck, L.; Alamillo, J.M.; Simon-Mateo, C.; Perez, J.J.; Fernandez-Fernandez, M.R.; Olszewski, N.E.; Garcia, J.A.
Identification of secret agent as the O-GlcNAc transferase that participates in Plum pox virus infection
J. Virol.
79
9381-9387
2005
Nicotiana benthamiana, Arabidopsis thaliana (Q96301), Arabidopsis thaliana (Q9M8Y0), Arabidopsis thaliana
Scott, C.L.; Hartweck, L.M.; de Jesus Perez, J.; Chen, D.; Garcia, J.A.; Olszewski, N.E.
SECRET AGENT, an Arabidopsis thaliana O-GlcNAc transferase, modifies the Plum pox virus capsid protein
FEBS Lett.
580
5829-5835
2006
Arabidopsis thaliana (Q96301), Arabidopsis thaliana (Q9M8Y0), Arabidopsis thaliana
Maerz, P.; Stetefeld, J.; Bendfeldt, K.; Nitsch, C.; Reinstein, J.; Shoeman, R.L.; Dimitriades-Schmutz, B.; Schwager, M.; Leiser, D.; Ozcan, S.; Otten, U.; Ozbek, S.
Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain
J. Biol. Chem.
281
20263-20270
2006
Homo sapiens (O15294), Rattus norvegicus (P56558)
Dehennaut, V.; Hanoulle, X.; Bodart, J.F.; Vilain, J.P.; Michalski, J.C.; Landrieu, I.; Lippens, G.; Lefebvre, T.
Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entry
Biochem. Biophys. Res. Commun.
369
539-546
2008
Homo sapiens
Clarke, A.J.; Hurtado-Guerrero, R.; Pathak, S.; Schuettelkopf, A.W.; Borodkin, V.; Shepherd, S.M.; Ibrahim, A.F.; van Aalten, D.M.
Structural insights into mechanism and specificity of O-GlcNAc transferase
EMBO J.
27
2780-2788
2008
Xanthomonas campestris, Homo sapiens (O15294)
Whelan, S.A.; Lane, M.D.; Hart, G.W.
Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling
J. Biol. Chem.
283
21411-21417
2008
Mus musculus
Martinez-Fleites, C.; Macauley, M.S.; He, Y.; Shen, D.L.; Vocadlo, D.J.; Davies, G.J.
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation
Nat. Struct. Mol. Biol.
15
764-765
2008
Homo sapiens, Xanthomonas campestris
Akimoto, Y.; Kreppel, L.K.; Hirano, H.; Hart, G.W.
Hyperglycemia and the O-GlcNAc transferase in rat aortic smooth muscle cells: elevated expression and altered patterns of O-GlcNAcylation
Arch. Biochem. Biophys.
389
166-175
2001
Rattus norvegicus (P56558)
Hanover, J.A.; Yu, S.; Lubas, W.B.; Shin, S.H.; Ragano-Caracciola, M.; Kochran, J.; Love, D.C.
Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene
Arch. Biochem. Biophys.
409
287-297
2003
Homo sapiens, Rattus norvegicus, Mus musculus (Q8CGY8), Mus musculus
Yang, W.H.; Park, S.Y.; Ji, S.; Kang, J.G.; Kim, J.-E.; Song, H.; Mook-Jung, I.; Choe, K.-M.; Cho, J.W.
O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation
Biochem. Biophys. Res. Commun.
391
756-761
2010
Homo sapiens
Zhang, L.; Ren, F.; Li, J.; Ma, X.; Wang, P.
A modified coupled enzyme method for O-linked GlcNAc transferase activity assay
Biol. Proced. Online
11
170-183
2009
Homo sapiens
Webster, D.M.; Teo, C.F.; Sun, Y.; Wloga, D.; Gay, S.; Klonowski, K.D.; Wells, L.; Dougan, S.T.
O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development
BMC Dev. Biol.
9
28
2009
Danio rerio (Q5GA10), Danio rerio (Q5GA12)
Akimoto, Y.; Kreppel, L.K.; Hirano, H.; Hart, G.W.
Localization of the O-linked N-acetylglucosamine transferase in rat pancreas
Diabetes
48
2407-2413
1999
Rattus norvegicus (P56558)
Golks, A.; Tran, T.T.; Goetschy, J.F.; Guerini, D.
Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation
EMBO J.
26
4368-4379
2007
Homo sapiens
Dieckmann-Schuppert, A.; Bause, E.; Schwarz, R.T.
Studies on O-glycans of Plasmodium-falciparum-infected human erythrocytes. Evidence for O-GlcNAc and O-GlcNAc-transferase in malaria parasites
Eur. J. Biochem.
216
779-788
1993
Homo sapiens
Hartweck, L.M.; Scott, C.L.; Olszewski, N.E.
Two O-linked N-acetylglucosamine transferase genes of Arabidopsis thaliana L. Heynh. have overlapping functions necessary for gamete and seed development
Genetics
161
1279-1291
2002
Arabidopsis thaliana (Q9M8Y0), Arabidopsis thaliana
Lazarus, B.D.; Love, D.C.; Hanover, J.A.
Recombinant O-GlcNAc transferase isoforms: identification of O-GlcNAcase, yes tyrosine kinase, and tau as isoform-specific substrates
Glycobiology
16
415-421
2006
Homo sapiens
Lima, V.V.; Giachini, F.R.; Carneiro, F.S.; Carneiro, Z.N.; Saleh, M.A.; Pollock, D.M.; Fortes, Z.B.; Carvalho, M.H.; Ergul, A.; Webb, R.C.; Tostes, R.C.
O-GlcNAcylation contributes to augmented vascular reactivity induced by endothelin 1
Hypertension
55
180-188
2010
Rattus norvegicus
Gross, B.J.; Kraybill, B.C.; Walker, S.
Discovery of O-GlcNAc transferase inhibitors
J. Am. Chem. Soc.
127
14588-14589
2005
Homo sapiens
Kreppel, L.K.; Hart, G.W.
Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of the tetratricopeptide repeats
J. Biol. Chem.
274
32015-32022
1999
Rattus norvegicus
Gao, Y.; Wells, L.; Comer, F.I.; Parker, G.J.; Hart, G.W.
Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain
J. Biol. Chem.
276
9838-9845
2001
Bos taurus
Iyer, S.P.; Hart, G.W.
Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity
J. Biol. Chem.
278
24608-24616
2003
Rattus norvegicus
Cheung, W.D.; Sakabe, K.; Housley, M.P.; Dias, W.B.; Hart, G.W.
O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins
J. Biol. Chem.
283
33935-33941
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Taylor, R.P.; Parker, G.J.; Hazel, M.W.; Soesanto, Y.; Fuller, W.; Yazzie, M.J.; McClain, D.A.
Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase
J. Biol. Chem.
283
6050-6057
2008
Homo sapiens
Okuyama, R.; Marshall, S.
UDP-N-acetylglucosaminyl transferase (OGT) in brain tissue: temperature sensitivity and subcellular distribution of cytosolic and nuclear enzyme
J. Neurochem.
86
1271-1280
2003
Rattus norvegicus
Caldwell, S.A.; Jackson, S.R.; Shahriari, K.S.; Lynch, T.P.; Sethi, G.; Walker, S.; Vosseller, K.; Reginato, M.J.
Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1
Oncogene
29
2831-2842
2010
Homo sapiens
Dorfmueller, H.C.; Borodkin, V.S.; Blair, D.E.; Pathak, S.; Navratilova, I.; van Aalten, D.M.
Substrate and product analogues as human O-GlcNAc transferase inhibitors
Amino Acids
40
781-972
2011
Homo sapiens
Dorfmueller, H.C.; Borodkin, V.S.; Blair, D.E.; Pathak, S.; Navratilova, I.; van Aalten, D.M.
Substrate and product analogues as human O-GlcNAc transferase inhibitors
Amino Acids
40
781-792
2010
Xanthomonas campestris pv. campestris
Lubas, W.A.; Frank, D.W.; Krause, M.; Hanover, J.A.
O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats
J. Biol. Chem.
272
9316-9324
1997
Caenorhabditis elegans, Oryctolagus cuniculus, Homo sapiens (O15294), Homo sapiens
Sakabe, K.; Hart, G.W.
O-GlcNAc transferase regulates mitotic chromatin dynamics
J. Biol. Chem.
285
34460-34468
2010
Homo sapiens
Zhang, F.; Snead, C.M.; Catravas, J.D.
Hsp90 regulates O-linked beta-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked beta-N-acetylglucosamine modification in endothelial cells
Am. J. Physiol. Cell Physiol.
302
C1786-C1796
2012
Bos taurus, Homo sapiens (O15294), Homo sapiens
Chikanishi, T.; Fujiki, R.; Hashiba, W.; Sekine, H.; Yokoyama, A.; Kato, S.
Glucose-induced expression of MIP-1 genes requires O-GlcNAc transferase in monocytes
Biochem. Biophys. Res. Commun.
394
865-870
2010
Homo sapiens (O15294)
Sakaidani, Y.; Ichiyanagi, N.; Saito, C.; Nomura, T.; Ito, M.; Nishio, Y.; Nadano, D.; Matsuda, T.; Furukawa, K.; Okajima, T.
O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1
Biochem. Biophys. Res. Commun.
419
14-19
2012
Mus musculus (Q8CGY8), Mus musculus
Ruan, H.B.; Han, X.; Li, M.D.; Singh, J.P.; Qian, K.; Azarhoush, S.; Zhao, L.; Bennett, A.M.; Samuel, V.T.; Wu, J.; Yates, J.R.; Yang, X.
O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1alpha stability
Cell Metab.
16
226-237
2012
Homo sapiens (O15294)
Capotosti, F.; Guernier, S.; Lammers, F.; Waridel, P.; Cai, Y.; Jin, J.; Conaway, J.W.; Conaway, R.C.; Herr, W.
O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1
Cell
144
376-388
2011
Homo sapiens (O15294)
Tvaroska, I.; Kozmon, S.; Wimmerova, M.; Koca, J.
Substrate-assisted catalytic mechanism of O-GlcNAc transferase discovered by quantum mechanics/molecular mechanics investigation
J. Am. Chem. Soc.
134
15563-15571
2012
Homo sapiens (O15294)
Shen, D.L.; Gloster, T.M.; Yuzwa, S.A.; Vocadlo, D.J.
Insights into O-linked N-acetylglucosamine (O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates
J. Biol. Chem.
287
15395-15408
2012
Homo sapiens (O15294), Homo sapiens
Gawlowski, T.; Suarez, J.; Scott, B.; Torres-Gonzalez, M.; Wang, H.; Schwappacher, R.; Han, X.; Yates, J.R.; Hoshijima, M.; Dillmann, W.
Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-beta-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes
J. Biol. Chem.
287
30024-30034
2012
Rattus norvegicus (P56558)
Iwashita, Y.; Fukuchi, N.; Waki, M.; Hayashi, K.; Tahira, T.
Genome-wide repression of NF-kappaB target genes by transcription factor MIBP1 and its modulation by O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase
J. Biol. Chem.
287
9887-9900
2012
Homo sapiens (O15294)
Jiang, J.; Lazarus, M.B.; Pasquina, L.; Sliz, P.; Walker, S.
A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase
Nat. Chem. Biol.
8
72-77
2012
Homo sapiens (O15294), Homo sapiens
Lazarus, M.B.; Jiang, J.; Gloster, T.M.; Zandberg, W.F.; Whitworth, G.E.; Vocadlo, D.J.; Walker, S.
Structural snapshots of the reaction coordinate for O-GlcNAc transferase
Nat. Chem. Biol.
8
966-968
2012
Homo sapiens (O15294)
Lazarus, M.; Nam, Y.; Jiang, J.; Sliz, P.; Walker, S.
Structure of human O-GlcNAc transferase and its complex with a peptide substrate
Nature
469
564-569
2011
Homo sapiens (O15294), Homo sapiens
Xu, J.; Wang, S.; Viollet, B.; Zou, M.H.
Regulation of the proteasome by AMPK in endothelial cells: the role of O-GlcNAc transferase (OGT)
PLoS ONE
7
e36717
2012
Mus musculus
Liu, Y.; Li, X.; Yu, Y.; Shi, J.; Liang, Z.; Run, X.; Li, Y.; Dai, C.L.; Grundke-Iqbal, I.; Iqbal, K.; Liu, F.; Gong, C.X.
Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain
PLoS ONE
7
e43724
2012
Rattus norvegicus (P56558)
Alfaro, J.F.; Gong, C.X.; Monroe, M.E.; Aldrich, J.T.; Clauss, T.R.; Purvine, S.O.; Wang, Z.; Camp, D.G.; Shabanowitz, J.; Stanley, P.; Hart, G.W.; Hunt, D.F.; Yang, F.; Smith, R.D.
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets
Proc. Natl. Acad. Sci. USA
109
7280-7285
2012
Mus musculus (Q8CGY8), Mus musculus
Borodkin, V.S.; Schimpl, M.; Gundogdu, M.; Rafie, K.; Dorfmueller, H.C.; Robinson, D.A.; van Aalten, D.M.
Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors
Biochem. J.
457
497-502
2014
Homo sapiens (O15294)
Trapannone, R.; Mariappa, D.; Ferenbach, A.T.; van Aalten, D.M.
Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins
Biochem. J.
473
1693-1702
2016
Homo sapiens (O15294), Homo sapiens
Kim, E.J.; Abramowitz, L.K.; Bond, M.R.; Love, D.C.; Kang, D.W.; Leucke, H.F.; Kang, D.W.; Ahn, J.S.; Hanover, J.A.
Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors
Bioconjug. Chem.
25
1025-1030
2014
Homo sapiens (O15294)
Im, J.
Synthesis of a benzene-containing C1-phosphonate analogue of UDP-GlcNAc for the inhibition of O-GlcNAc transferase
Bull. Korean Chem. Soc.
37
7-12
2016
Homo sapiens
-
Pekkurnaz, G.; Trinidad, J.C.; Wang, X.; Kong, D.; Schwarz, T.L.
Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase
Cell
158
54-68
2014
Rattus norvegicus
Liu, X.; Li, L.; Wang, Y.; Yan, H.; Ma, X.; Wang, P.G.; Zhang, L.
A peptide panel investigation reveals the acceptor specificity of O-GlcNAc transferase
FASEB J.
28
3362-3372
2014
Homo sapiens
Sokol, K.A.; Olszewski, N.E.
The putative eukaryote-like O-GlcNAc transferase of the cyanobacterium Synechococcus elongatus PCC 7942 hydrolyzes UDP-GlcNAc and is involved in multiple cellular processes
J. Bacteriol.
197
354-361
2015
Synechococcus elongatus (Q31S86), Synechococcus elongatus PCC 7942 (Q31S86)
Shi, W.W.; Jiang, Y.L.; Zhu, F.; Yang, Y.H.; Shao, Q.Y.; Yang, H.B.; Ren, Y.M.; Wu, H.; Chen, Y.; Zhou, C.Z.
Structure of a novel O-linked N-acetyl-D-glucosamine (O-GlcNAc) transferase, GtfA, reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins
J. Biol. Chem.
289
20898-20907
2014
Streptococcus pneumoniae TIGR4 (A0A0H2URG7), Streptococcus pneumoniae TIGR4 ATCC BAA-334 (A0A0H2URG7)
Rodriguez, A.C.; Yu, S.H.; Li, B.; Zegzouti, H.; Kohler, J.J.
Enhanced transfer of a photocross-linking N-acetylglucosamine (GlcNAc) analog by an O-GlcNAc transferase mutant with converted substrate specificity
J. Biol. Chem.
290
22638-22648
2015
Homo sapiens
Zhang, Z.; Costa, F.C.; Tan, E.P.; Bushue, N.; DiTacchio, L.; Costello, C.E.; McComb, M.E.; Whelan, S.A.; Peterson, K.R.; Slawson, C.
O-GlcNAc transferase and O-GlcNAcase interact with Mi2beta at the Agamma-globin promoter
J. Biol. Chem.
291
15628-15640
2016
Homo sapiens
Kumari, M.; Kozmon, S.; Kulhanek, P.; Stepan, J.; Tvaroska, I.; Koca, J.
Exploring reaction pathways for O-GlcNAc transferase catalysis. A string method study
J. Phys. Chem. B
119
4371-4381
2015
Homo sapiens (O15294)
Pathak, S.; Alonso, J.; Schimpl, M.; Rafie, K.; Blair, D.; Borodkin, V.; Schüttelkopf, A.; Albarbarawi, O.; Van Aalten, D.
The active site of O-GlcNAc transferase imposes constraints on substrate sequence
Nat. Struct. Mol. Biol.
22
744-749
2015
Homo sapiens (O15294)
Mariappa, D.; Zheng, X.; Schimpl, M.; Raimi, O.; Ferenbach, A.; Müller, H.; Van Aalten, D.
Dual functionality of O-GlcNAc transferase is required for Drosophila development
Open Biology
5
15023
2015
Drosophila melanogaster (Q7KJA9)
Shi, J.; Sharif, S.; Ruijtenbeek, R.; Pieters, R.J.
Activity based high-throughput screening for novel O-GlcNAc transferase substrates using a dynamic peptide microarray
PLoS ONE
11
e0151085
2016
Homo sapiens (O15294)
Mueller, R.; Jenny, A.; Stanley, P.
The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila
PLoS ONE
8
e62835
2013
Homo sapiens (Q5NDL2), Drosophila melanogaster (Q9VQB7)
Ma, X.; Liu, P.; Yan, H.; Sun, H.; Liu, X.; Zhou, F.; Li, L.; Chen, Y.; Muthana, M.M.; Chen, X.; Wang, P.G.; Zhang, L.
Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT)
PLoS ONE
8
e63452
2013
Homo sapiens (O15294), Homo sapiens
Trapannone, R.; Rafie, K.; van Aalten, D.M.
O-GlcNAc transferase inhibitors current tools and future challenges
Biochem. Soc. Trans.
44
88-93
2016
Homo sapiens (O15294)
She, N.; Zhao, Y.; Hao, J.; Xie, S.; Wang, C.
Uridine diphosphate release mechanism in O-N-acetylglucosamine (O-GlcNAc) transferase catalysis
Biochim. Biophys. Acta Gen. Subj.
1863
609-622
2019
Homo sapiens (O15294)
Ghirardello, M.; Perrone, D.; Chinaglia, N.; Sadaba, D.; Delso, I.; Tejero, T.; Marchesi, E.; Fogagnolo, M.; Rafie, K.; van Aalten, D.M.F.; Merino, P.
UDP-GlcNAc analogues as inhibitors of O-GlcNAc transferase (OGT) spectroscopic, computational, and biological studies
Chemistry
24
7264-7272
2018
Homo sapiens (O15294)
Xing, L.; Liu, Y.; Xu, S.; Xiao, J.; Wang, B.; Deng, H.; Lu, Z.; Xu, Y.; Chong, K.
Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering
EMBO J.
37
e98115
2018
Arabidopsis thaliana (Q9M8Y0)
Constable, S.; Lim, J.M.; Vaidyanathan, K.; Wells, L.
O-GlcNAc transferase regulates transcriptional activity of human Oct4
Glycobiology
27
927-937
2017
Homo sapiens (O15294), Homo sapiens
Martin, S.E.S.; Tan, Z.W.; Itkonen, H.M.; Duveau, D.Y.; Paulo, J.A.; Janetzko, J.; Boutz, P.L.; Toerk, L.; Moss, F.A.; Thomas, C.J.; Gygi, S.P.; Lazarus, M.B.; Walker, S.
Structure-based evolution of low nanomolar O-GlcNAc transferase inhibitors
J. Am. Chem. Soc.
140
13542-13545
2018
Homo sapiens
Levine, Z.G.; Fan, C.; Melicher, M.S.; Orman, M.; Benjamin, T.; Walker, S.
O-GlcNAc transferase recognizes protein substrates using an asparagine ladder in the tetratricopeptide repeat (TPR) superhelix
J. Am. Chem. Soc.
140
3510-3513
2018
Homo sapiens (O15294)
Darabedian, N.; Gao, J.; Chuh, K.N.; Woo, C.M.; Pratt, M.R.
The metabolic chemical reporter 6-azido-6-deoxy-glucose further reveals the substrate promiscuity of O-GlcNAc transferase and catalyzes the discovery of intracellular protein modification by O-glucose
J. Am. Chem. Soc.
140
7092-7100
2018
Homo sapiens (O15294)
Joiner, C.M.; Levine, Z.G.; Aonbangkhen, C.; Woo, C.M.; Walker, S.
Aspartate residues far from the active site drive O-GlcNAc transferase substrate selection
J. Am. Chem. Soc.
141
12974-12978
2019
Homo sapiens (O15294)
Sacoman, J.L.; Dagda, R.Y.; Burnham-Marusich, A.R.; Dagda, R.K.; Berninsone, P.M.
Mitochondrial O-GlcNAc transferase (mOGT) regulates mitochondrial structure, function, and survival in HeLa cells
J. Biol. Chem.
292
4499-4518
2017
Homo sapiens (O15294)
Liu, L.; Li, L.; Ma, C.; Shi, Y.; Liu, C.; Xiao, Z.; Zhang, Y.; Tian, F.; Gao, Y.; Zhang, J.; Ying, W.; Wang, P.G.; Zhang, L.
O-GlcNAcylation of Thr12/Ser56 in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity
J. Biol. Chem.
294
16620-16633
2019
Homo sapiens (O15294)
Alam, S.M.D.; Tsukamoto, Y.; Ogawa, M.; Senoo, Y.; Ikeda, K.; Tashima, Y.; Takeuchi, H.; Okajima, T.
N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization
J. Biol. Chem.
295
8560-8574
2020
Mus musculus (Q8BYW9), Mus musculus
Cao, B.; Duan, M.; Xing, Y.; Liu, C.; Yang, F.; Li, Y.; Yang, T.; Wei, Y.; Gao, Q.; Jiang, J.
O-GlcNAc transferase activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E
J. Cell. Mol. Med.
23
2384-2398
2019
Homo sapiens (O15294), Homo sapiens
Wang, Y.; Zhu, J.; Zhang, L.
Discovery of cell-permeable O-GlcNAc transferase inhibitors via tethering in situ click chemistry
J. Med. Chem.
60
263-272
2017
Homo sapiens (O15294)
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