2.6.1.44: alanine-glyoxylate transaminase

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For detailed information about alanine-glyoxylate transaminase, go to the full flat file.

Reaction

Synonyms

3-hydroxykynurenine transaminase, 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase, AGT, AGT-Ma, AGT-Mi, AGT1, AGT2, AGX, AGXT, AGXT2, alanine aminotransferase, alanine glyoxalate transaminase 2, alanine glyoxylate aminotransferase, alanine-glyoxalate aminotransferase, alanine-glyoxalate transaminase 1, alanine-glyoxylate aminotransferase, alanine-glyoxylate aminotransferase 2, alanine-glyoxylate aminotransferase isoenzyme 2, alanine-glyoxylate aminotransferase-2, alanine-glyoxylic aminotransferase, alanine: glyoxylate aminotransferase, alanine:2-oxoglutarate aminotransferase, alanine:glyoxylate aminotransferase, alanine:glyoxylate aminotransferase 1, alanine:glyoxylate aminotransferase 2, alanine:glyoxylate aminotransferase type 1, alanine:glyoxylate aminotransferase/beta-alanine:pyruvate aminotransferase, aminotransferase 3, AT3, At3g08860, cytosolic alanine aminotransferase, D-AIB AT, EC 2.6.1.51, GGT, glyoxylate aminotransferase AGT1, L-alanine-glycine transaminase, L-alanine-glyoxylate aminotransferase, L-alanine:glyoxylate aminotransferase, More, serine pyruvate aminotransferase, serine:pyruvate/alanine:glyoxylate aminotransferase, SPT/AGT

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.44 alanine-glyoxylate transaminase

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Results	in table
6	Activating Compound
3685	AA Sequence
17	Application
1	CAS Registry Number
55	Cloned(Commentary)
38	Cofactor
13	Crystallization (Commentary)
482	Disease/ Diagnostics
3	Expression
32	General Information
5	General Stability
31	Inhibitors
46	kcat/KM [mM/s]
9	Ki Value [mM]
130	KM Value [mM]
87	Localization
61	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
119	Organism
1	Oxidation Stability
8	Pathway
52	PDB ID
26	pH Optimum
5	pH Range
2	pH Stability
5	pI Value
93	Protein Variants
33	Purification (Commentary)
4	Reaction
1	Reaction Type
115	Reference
2	Renatured (Commentary)
84	Source Tissue
17	Specific Activity [micromol/min/mg]
19	Storage Stability
167	Substrates and Products (Substrate)
52	Subunits
112	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
3	Temperature Range [°C]
5	Temperature Stability [°C]
68	Turnover Number [1/s]

General Stability

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General Stability on EC 2.6.1.44 - alanine-glyoxylate transaminase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

human AGT can substitute for function of yeast Agx1 (Yeast alanine:glyoxylate aminotransferase) and that mutations associated with disease in humans show reduced growth in yeast. The reduced growth of minor allele mutants reflects reduced protein levels, indicating that these proteins are less stable than wild-type AGT in yeast

Homo sapiens

-

687769

major allele (P11/I340) is more stable against increasing urea concentrations than minor allele (P11L/I340M) or mutant protein P11L/I340M/G170R

Homo sapiens

-

721754

partial digestion by trypsin provides an indicator of proper folding of the enzyme, while for some mutants, sensitivity to trypsin can be ameliorated by addition of pyridoxal 5'-phosphate or aminooxyacetic acid

Homo sapiens

-

689026

partial trypsin digestion provides an indicator of proper folding of the mutant enzyme. For selected mutations the sensitivity to trypsin can be ameliorated by addition of pyridoxal phosphate or aminooxy acetic acid as specific pharmacological chaperones

Homo sapiens

-

689026

pyridoxal 5'-phosphate stabilizes during purification

Gallus gallus

-

640074