2.7.4.3: adenylate kinase This is an abbreviated version! For detailed information about adenylate kinase, go to the full flat file .
Reaction
ATP +
AMP =
2 ADP
Synonyms 5'-AMP-kinase, ABC adenylate kinase, AD-004 like protein, adenosine 5'-triphosphate:adenosine 5'-monophosphate phosphotransferase, adenylate kinase, adenylate kinase 1, adenylate kinase 2, adenylate kinase 4, adenylate kinase 5, adenylate kinase 6, adenylate kinase 9, adenylate kinase isoenzyme 1, adenylate kinase isozyme 2, adenylate kinase-2, adenylate kinase-like protein 1, adenylic kinase, adenylokinase, ADK, ADK1, ADK2, ADLP, AK1, AK2, AK4, AK5, AK5p1, AK5p2, AK6, AK7, AK8, AK9, AKE, AKlse4, AKm, AKmeso, AKp, AKpsycrho, AKthermo, ATP:AMP phosphotransferase, CFTR, CINAP, coilin interacting nuclear ATPase protein, cystic fibrosis transmembrane conductance regulator, DAK2, Dak6, kinase, adenylate (phosphorylating), kinase, myo- (phosphorylating), MeADK1, MeADK2, MJ0458, myokinase, nonstructural protein 4B, NS4B, pfSMCnbd, phosphotransferase, Rv0733, Saci_0573, SpAdK, structural maintenance of chromosome protein
ECTree
Localization
Localization on EC 2.7.4.3 - adenylate kinase
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isoenzyme AK1b
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isolated embryonic cilia. A 130000 Dalton isoform is responsible for 93% of nonmitochondrial ATP regeneration from ADP in cilia. Presence of at least one additional adenylate kinase isoform
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adenylate kinase isoform D
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extracellular activity is less than 1% of total activity and due to leaking from leaving cells or to dying cells
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N-myristoylation is required to target isoform AK2 to the parasitophorous vacuole membrane
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isoenzyme AK1b
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nucleolar localization is dependent on nutrient availability and active transcription and ribosome assembly and is lost upon oxidative stress
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decreased expression in growing tubers leads to increased rates of respiratory oxygen consumption and increased carbon fluxes into starch. Increased rates of starch synthesis are accompanied by post-translational redox-activation of ADP-glucose diphosphorylase, while there are no substantial changes in metabolic intermediates or sugar levels
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isoforms AMK2 and AMK5
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isoforms AMK3 and AMK4
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cytosolic and mitochondrial kinases are distinct isozymes
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isoform adenylate kinase 1
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breast muscle enzyme
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isoenzyme AK1
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isoform AK1 and adenylate kinase-like protein 1
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isozyme II
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Rhodopseudomonas rubrum
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cytosolic and mitochondrial kinases are distinct isozymes
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extracellular activity is less than 1% of total activity and due to leaking from leaving cells or to dying cells
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cytoplasmic adenylate kinase 1 is secreted from myotubes but not from myoblasts
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localizes along the entire flagellum, tightly bound to the axoneme. Enzyme contributes 31% of the total non-mitochondrial ATP synthesis associated with the demembranated axoneme
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sperm flagellum. 31% of the nonmitochondrial ATP regeneration are due to the 130000 Dalton adenylate kinase isozyme and 69% due to the flagellar creatine kinase
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isofrms AMK21and AMK7
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most highly expressed isoform AK1
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intermembrane space
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intermembrane space
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cytosolic and mitochondrial kinases are distinct isozymes
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localized in the mitochondrial intermembrane space
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liver enzyme
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intermembrane space
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intermembrane space
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after 2 h from heat shock, rate of ADT/ATP exchange by adenine nucleotide translocator activity, adenylate kinase activity and nucleoside diphosphate kinase EC 2.7.4.6 are inhibitied in a non-competitive-like manner. Externally added ascorbate prevents the inhibition
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intermembrane space
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intermembrane space
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intermembrane space
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cytosolic and mitochondrial kinases are distinct isozymes
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predominant localization
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predominant nuclear localization
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presence of an ecto-adenylate kinase
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additional information
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isoforms AMK1 to AMK5 are much higher expressed than AMK6, while AMK7 is at the detection limit
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additional information
isoforms AMK1 to AMK5 are much higher expressed than AMK6, while AMK7 is at the detection limit
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isoforms AMK1 to AMK5 are much higher expressed than AMK6, while AMK7 is at the detection limit
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additional information
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stroma-associated
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localizes to the mitochondrial sheath in sperm midpiece
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localizes to the mitochondrial sheath in sperm midpiece
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localizes to the mitochondrial sheath in sperm midpiece
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localizes to the sodium dodecyl sulfate insoluble sperm tail fraction
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localizes to the sodium dodecyl sulfate insoluble sperm tail fraction
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localizes to the sodium dodecyl sulfate insoluble sperm tail fraction
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particle-associated
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subcellular distribution of 4 rat isozymes
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