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2.7.4.3: adenylate kinase

This is an abbreviated version!
For detailed information about adenylate kinase, go to the full flat file.

Word Map on EC 2.7.4.3

Reaction

ATP
+
AMP
=
2 ADP

Synonyms

5'-AMP-kinase, ABC adenylate kinase, AD-004 like protein, adenosine 5'-triphosphate:adenosine 5'-monophosphate phosphotransferase, adenylate kinase, adenylate kinase 1, adenylate kinase 2, adenylate kinase 4, adenylate kinase 5, adenylate kinase 6, adenylate kinase 9, adenylate kinase isoenzyme 1, adenylate kinase isozyme 2, adenylate kinase-2, adenylate kinase-like protein 1, adenylic kinase, adenylokinase, ADK, ADK1, ADK2, ADLP, AK1, AK2, AK4, AK5, AK5p1, AK5p2, AK6, AK7, AK8, AK9, AKE, AKlse4, AKm, AKmeso, AKp, AKpsycrho, AKthermo, ATP:AMP phosphotransferase, CFTR, CINAP, coilin interacting nuclear ATPase protein, cystic fibrosis transmembrane conductance regulator, DAK2, Dak6, kinase, adenylate (phosphorylating), kinase, myo- (phosphorylating), MeADK1, MeADK2, MJ0458, myokinase, nonstructural protein 4B, NS4B, pfSMCnbd, phosphotransferase, Rv0733, Saci_0573, SpAdK, structural maintenance of chromosome protein

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.3 adenylate kinase

Localization

Localization on EC 2.7.4.3 - adenylate kinase

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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
isoenzyme AK1b
-
Manually annotated by BRENDA team
-
isolated embryonic cilia. A 130000 Dalton isoform is responsible for 93% of nonmitochondrial ATP regeneration from ADP in cilia. Presence of at least one additional adenylate kinase isoform
Manually annotated by BRENDA team
-
adenylate kinase isoform D
Manually annotated by BRENDA team
-
extracellular activity is less than 1% of total activity and due to leaking from leaving cells or to dying cells
Manually annotated by BRENDA team
-
N-myristoylation is required to target isoform AK2 to the parasitophorous vacuole membrane
Manually annotated by BRENDA team
-
isoenzyme AK1b
Manually annotated by BRENDA team
-
nucleolar localization is dependent on nutrient availability and active transcription and ribosome assembly and is lost upon oxidative stress
Manually annotated by BRENDA team
-
decreased expression in growing tubers leads to increased rates of respiratory oxygen consumption and increased carbon fluxes into starch. Increased rates of starch synthesis are accompanied by post-translational redox-activation of ADP-glucose diphosphorylase, while there are no substantial changes in metabolic intermediates or sugar levels
Manually annotated by BRENDA team
additional information