2.7.6.1: ribose-phosphate diphosphokinase

This is an abbreviated version!
For detailed information about ribose-phosphate diphosphokinase, go to the full flat file.

Word Map on EC 2.7.6.1

2.7.6.1

purine

erythrocyte

superactivity

pyrimidine

x-linked

phosphoribosyltransferase

uric

gout

hypoxanthine

hypoxanthine-guanine

deafness

charcot-marie-tooth

sensorineural

hemolysates

diphosphorylated

nonsyndromic

hgprt

hyperuricaemia

lesch-nyhan

phosphoribosyl-pyrophosphate

feedback-resistant

synthesis

medicine

Reaction

Synonyms

5-phospho-alpha D-ribosyl 1-diphosphate synthase, 5-phosphoribose pyrophosphorylase, 5-phosphoribosyl-1-alpha-diphosphate synthase, 5-phosphoribosyl-1-pyrophosphate synthetase, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase, AN6711.2, ATP: D-ribose-5-phosphate pyrophosphotransferase, ATP:D-ribose-5-phosphate pyrophosphotransferase, bsPRS, Pcal_1127, phosphoribosyl diphosphate synthase, phosphoribosyl pyrophosphate synthase 1 (PRS-1), phosphoribosyl pyrophosphate synthase enzyme, phosphoribosyl pyrophosphate synthetase, phosphoribosyl-1-pyrophosphate synthetase, phosphoribosyl-diphosphate synthetase, phosphoribosylpyrophosphate synthase, phosphoribosylpyrophosphate synthetase, phosphoribosylpyrophosphate synthetase 1, phosphoribosylpyrophosphate synthetase subunit 1, PP-ribose P synthetase, PPRibP synthetase, PRibPP synthase, PRPP synthase, PRPP synthetase, PRPPase, PRPPS, PRPPS1, PRPPS2, PRPS1, Prps1a, Prps1b, PRS, PRS-I, PRS1, Prs4, PrsA, PrsB, PrsC, pyrophosphokinase, ribose phosphate, pyrophosphoribosylphosphate synthetase, ribophosphate pyrophosphokinase, ribose-5-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase 1, RPPK, SSO1045, TT_C1184, TT_C1274

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.6 Diphosphotransferases

2.7.6.1 ribose-phosphate diphosphokinase

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Results	in table
57	Activating Compound
43931	AA Sequence
3	Application
1	CAS Registry Number
34	Cloned(Commentary)
7	Cofactor
19	Crystallization (Commentary)
506	Disease/ Diagnostics
2	Expression
19	General Information
12	General Stability
21	IC50 Value
238	Inhibitors
13	kcat/KM [mM/s]
51	Ki Value [mM]
171	KM Value [mM]
13	Localization
114	Metals/Ions
74	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
295	Organism
8	Pathway
89	PDB ID
28	pH Optimum
8	pH Range
6	pH Stability
12	pI Value
38	Protein Variants
34	Purification (Commentary)
23	Reaction
1	Reaction Type
100	Reference
51	Source Tissue
60	Specific Activity [micromol/min/mg]
12	Storage Stability
220	Substrates and Products (Substrate)
57	Subunits
112	Synonyms
1	Systematic Name
27	Temperature Optimum [°C]
1	Temperature Range [°C]
14	Temperature Stability [°C]
17	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.7.6.1 - ribose-phosphate diphosphokinase

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(R)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate

(R)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate

3 entries

(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate

(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate

3 entries

(S)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate

(S)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate

3 entries

(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate

(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate

3 entries

2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate + 5-phospho-alpha-D-ribose 1-diphosphate

2',3'-dideoxy-2',3'-didehydro-adenosine-5'-triphosphate + D-ribose 5-phosphate

3 entries

5'-adenylyl-beta,gamma-imidodiphosphate + D-ribose 5-phosphate

2 entries

9-(2-phosphonylmethoxyethoxy)adenine + 5-phospho-alpha-D-ribose 1-diphosphate

9-(2-phosphonylmethoxyethoxy)adenine-diphosphate + D-ribose 5-phosphate

3 entries

9-(2-phosphonylmethoxyethyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate

9-(2-phosphonylmethoxyethyl)adenine-diphosphate + D-ribose 5-phosphate

3 entries

AMP + 5-phospho-alpha-D-ribose 1-diphosphate

ATP + D-ribose 5-phosphate

3 entries

ATP + 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate

2 entries

ATP + 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate

2 entries

ATP + 6-deoxyhomoribose 6-phosphonate

AMP + 6-deoxyhomoribose 6-phosphonate 1-diphosphate

3 entries

ATP + D-ribose 5-phosphate

AMP + 5-phospho-alpha-D-ribose 1-diphosphate

109 entries

ATP + D-ribose 5-phosphothionate

AMP + 5-phosphotionate-alpha-D-ribose 1-diphosphate

3 entries

ATP + ribulose-5-phosphate

AMP + 5-phospho-ribulose-1-diphosphate

Homo sapiens

642730

CTP + D-ribose 5-phosphate

CMP + 5-phospho-alpha-D-ribose 1-diphosphate

14 entries

D-ribose 5-phosphate + ATP

5-phospho-alpha-D-ribose 1-diphosphate + AMP

Homo sapiens

P60891

biosynthesis of purines and pyrimidines

671203

D-ribose 5-phosphate + ATP

phosphoribosyldiphosphate + AMP

2 entries

dATP + D-ribose 5-phosphate

dAMP + 5-phospho-alpha-D-ribose 1-diphosphate

11 entries

GTP + D-ribose 5-phosphate

GMP + 5-phospho-alpha-D-ribose 1-diphosphate

9 entries

ITP + D-ribose 5-phosphate

IMP + 5-phospho-alpha-D-ribose 1-diphosphate

2 entries

Mg-ATP2- + D-ribose 5-phosphate

Mg-AMP2- + 5-phospho-alpha-D-ribose 1-diphosphate

2 entries

Mn-ATP2- + D-ribose 5-phosphate

Mn-AMP + 5-phospho-alpha-D-ribose 1-diphosphate

2 entries

ribose-5-phosphate + ATP

phosphoribosyldiphosphate + AMP

Homo sapiens

P60891

first step in purine metabolic pathway

671202

UTP + D-ribose 5-phosphate

UMP + 5-phospho-alpha-D-ribose 1-diphosphate

14 entries

additional information

17 entries