1.1.1.168: 2-dehydropantolactone reductase (Re-specific)

This is an abbreviated version!
For detailed information about 2-dehydropantolactone reductase (Re-specific), go to the full flat file.

Word Map on EC 1.1.1.168

Reaction

(R)-pantolactone
+
NADP+
=
2-dehydropantolactone
+
NADPH
+
H+

Synonyms

(R)-pantoyl-lactone:NADP+ oxidoreductase (A-specific), 2-dehydropantoyl-lactone reductase, 2-dehydropantoyl-lactone reductase (A-specific), 2-ketopantoyl lactone reductase, AKR, CPR, ketopantoyl lactone reductase, NADPH-dependent aldo-keto reductase, NADPH-dependent conjugated polyketone reductase, reductase, 2-oxopantoyl lactone

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.168 2-dehydropantolactone reductase (Re-specific)

Reference

Reference on EC 1.1.1.168 - 2-dehydropantolactone reductase (Re-specific)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
King, H.L.; Wilken, D.R.
Separation and preliminary studies on 2-ketopantoyl lactone and 2-ketopantoic acid reductases of yeast
J. Biol. Chem.
247
4096-4098
1972
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Wilken, D.R.; King, H.L.; Dyar, R.E.
Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate
J. Biol. Chem.
250
2311-2314
1975
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hata, H.; Shimizu, S.; Hattori, S.; Yamada, H.
Ketopantoyl-lactone reductase is a conjugated polyketone reductase
FEMS Microbiol. Lett.
58
87-90
1989
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hata, H.; Shimizu, S.; Hattori, S.; Yamada, H.
Ketopantoyl-lactone reductase from Candida parapsilosis: purification and characterization as a conjugated polyketone reductase
Biochim. Biophys. Acta
990
175-181
1989
Candida parapsilosis
Manually annotated by BRENDA team
Wilken, D.R.; Dyar, R.E.
Stereospecificity of pantoyl lactone formed by yeast cells and purified yeast ketopantoyl lactone reductases
Arch. Biochem. Biophys.
189
251-255
1978
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wilken, D.R.; King, H.L.; Dyar, R.E.
Ketopantoyl lactone reductases
Methods Enzymol.
62
209-215
1979
Saccharomyces cerevisiae
Manually annotated by BRENDA team
King, H.L.; Dyar, R.E.; Wilken, D.R.
Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase
J. Biol. Chem.
249
4689-4695
1974
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kataoka, M.; Nomura, Y.; Shimizu, S.; Yamada, H.
Enzymes involved in the NADPH regeneration system coupled with asymmetric reduction of carbonyl compounds in microorganisms
Biosci. Biotechnol. Biochem.
56
820-821
1992
Saccharomyces cerevisiae, Candida parapsilosis, Mucor ambiguus, Mucor ambiguus AKU 3006
Manually annotated by BRENDA team
Julliard, J.H.
Purification and characterization of oxopantoyl lactone reductase from higher plants: role in pantothenate synthesis
Bot. Acta
107
191-200
1994
Spinacia oleracea
-
Manually annotated by BRENDA team
Cheng, P.; Wang, J.; Wu, Y.; Jiang, X.; Pei, X.; Su, W.
Recombinant expression and molecular insights into the catalytic mechanism of an NADPH-dependent conjugated polyketone reductase for the asymmetric synthesis of (R)-pantolactone
Enzyme Microb. Technol.
126
77-85
2019
Candida dubliniensis (B9WJQ5), Candida dubliniensis, Candida dubliniensis CD36 (B9WJQ5), Candida dubliniensis CD36
Manually annotated by BRENDA team
Wang, J.; Cheng, P.; Wu, Y.; Wang, A.; Liu, F.; Pei, X.
Discovery of a new NADPH-dependent aldo-keto reductase from Candida orthopsilosis catalyzing the stereospecific synthesis of (R)-pantolactone by genome mining
J. Biotechnol.
291
26-34
2019
Candida orthopsilosis (H8XA83), Candida orthopsilosis, Candida orthopsilosis 90-125 (H8XA83)
Manually annotated by BRENDA team