1.13.11.31: arachidonate 12-lipoxygenase
This is an abbreviated version!
For detailed information about arachidonate 12-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.31
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1.13.11.31
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arachidonic
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cyclooxygenase
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12-hete
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eicosanoids
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prostaglandin
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artery
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linoleic
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neutrophil
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phospholipase
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atherosclerosis
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polyunsaturated
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endothelial
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asthma
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12-hydroxyeicosatetraenoic
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cox-2
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lipoxins
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monocyte
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baicalein
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hetes
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reticulocyte
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nordihydroguaiaretic
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thromboxane
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eicosapentaenoic
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ndga
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hydroperoxide
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atherogenesis
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indomethacin
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polymorphonuclear
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docosahexaenoic
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5-lipoxygenase-activating
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erythroderma
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polyenoic
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ichthyosis
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ichthyosiform
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phenidone
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lipoxygenase-1
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esculetin
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medicine
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pro-resolving
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oxylipins
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ferroptosis
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5,8,11,14-eicosatetraynoic
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hydroperoxy
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resolvins
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protectins
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etya
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drug development
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a23187-stimulated
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hydroxyeicosatetraenoic
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14carachidonic
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zileuton
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13-hode
- 1.13.11.31
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arachidonic
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cyclooxygenase
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12-hete
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eicosanoids
- prostaglandin
- artery
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linoleic
- neutrophil
- phospholipase
- atherosclerosis
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polyunsaturated
- endothelial
- asthma
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12-hydroxyeicosatetraenoic
- cox-2
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lipoxins
- monocyte
- baicalein
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hetes
- reticulocyte
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nordihydroguaiaretic
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thromboxane
-
eicosapentaenoic
- ndga
- hydroperoxide
- atherogenesis
- indomethacin
-
polymorphonuclear
-
docosahexaenoic
-
5-lipoxygenase-activating
- erythroderma
-
polyenoic
- ichthyosis
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ichthyosiform
- phenidone
- lipoxygenase-1
- esculetin
- medicine
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pro-resolving
- oxylipins
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ferroptosis
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5,8,11,14-eicosatetraynoic
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hydroperoxy
-
resolvins
-
protectins
- etya
- drug development
-
a23187-stimulated
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hydroxyeicosatetraenoic
-
14carachidonic
- zileuton
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13-hode
Reaction
Synonyms
(12R)-lipoxygenase, (12R)-LOX, 11R-lipoxygenase, 11R-LOX, 12(R)-lipoxygenase, 12(S)-lipoxygenase, 12-hLO, 12-lipoxygenase, 12-LO, 12-LOX, 12/15 lipoxygenase, 12/15-lipoxygenase, 12/15-lipoxygenases, 12/15-LO, 12/15-LOX, 12/15LO, 12DELTA-lipoxygenase, 12LO, 12R-lipoxygenase, 12R-LOX, 12R-LOX-2, 12S-lipoxygenase, 15-lipoxygenase, 15-LO, 2-lipoxygenase, 2/15-lipoxygenase, ALOX 12, ALOX 12/15, ALOX12, Alox12b, Alox15, ALOX15B, ALOX5, arachidonate 12/15-lipoxygenase, C-12 lipoxygenase, cardiac 12/15-LOX, DELTA 12-lipoxygenase, epidermal-type lipoxygenase, hp-12LOX, human platelet 12-lipoxygenase, leukocyte-type 12-lipoxygenase, leukocyte-type 12-LOX, leukocyte-type 12/15-lipoxygenase, leukocyte-type lipoxygenase, leukotriene A4 synthase M, lipoxygenase 12, LOX, LOX-12, LTA4 synthase, oxylipin-producing enzyme, oygenase, arachidonate 12-lip-, P-12LOX, p12-LO, p12-LOX, platelet 12-lipoxygenase, platelet-type 12(S)-lipoxygenase, platelet-type 12-human lipoxygenase, platelet-type 12-lipoxygenase, platelet-type 12-LOX, platelet-type 12LO, Platelet-type lipoxygenase 12, zf12-LOX
ECTree
1.13.11.31 arachidonate 12-lipoxygenaseAdvanced search results
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Localization
Localization on EC 1.13.11.31 - arachidonate 12-lipoxygenase
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LOCALIZATION 
ORGANISM
UNIPROT
COMMENTARY 
GeneOntology No.
LITERATURE
SOURCE
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primarily associated with cytoplasmic vascular smooth muscle cell muscle fibrils binding to alpha-actin, a component of the cytoplasmic myofilaments, not associated with 12-LO serine or tyrosine phosphorylation, overview, the binding is induced by angiotensin II
membrane binding activities of wild-type platelet 12-lipoxygenase and mutant enzymes at pH 7.4, role of the PLAT domain membrane binding, overview
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enzyme is expressed in a cryptic, microsomal-type form in primary culture epithelial cells, this form of enzyme may be selectively regulated by changes in cellular oxidation-reduction conditions dependent on cytosolic levels of GSH versus lipid hydroperoxide
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