1.14.14.47: nitric-oxide synthase (flavodoxin)
This is an abbreviated version!
For detailed information about nitric-oxide synthase (flavodoxin), go to the full flat file.
Word Map on EC 1.14.14.47
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1.14.14.47
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familia
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latino
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pacientes
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farmworker
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grupos
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condom
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analysis
- 1.14.14.47
-
familia
-
latino
-
pacientes
-
farmworker
-
grupos
-
condom
- analysis
Reaction
2 L-arginine + 2 reduced flavodoxin + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 oxidized flavodoxin + 2 H2O
Synonyms
bNOS, GK1676, nitric oxide synthetase, NO synthase, NOS, SANOS, YumC
ECTree
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Inhibitors
Inhibitors on EC 1.14.14.47 - nitric-oxide synthase (flavodoxin)
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3-[2,4-di(6-amino-4-methylpyridin-2-yl)ethyl]benzonitrile
inhibitor binds to heme propionate A through a bifurcated H-bond and a pi-pi stacking interaction between the conserved Tyr and aminopyridine group
4-methylquinolin-2-amine
among the most potent aminoquinoline inhibitors tested, KS value 0.00080 mM
6,6'-[(5-amino-1,3-phenylene)di(ethane-2,1-diyl)]bis(4-methylpyridin-2-amine)
compound interacts with the active site Glu243 and heme propionate D through a series of hydrogen bonds between the aminopyridine functional groups. Comparison with inhibition of mammalian NOS isoforms
6,6'-[[(2S,3S)-2-aminobutane-1,3-diyl]bis(oxymethanediyl)]bis(4-methylpyridin-2-amine)
compound impedes the growth of Bacillus subtilis under oxidative stress an is able to displace the tetrahydrobiopterin cofactor in the Bacillus subtilis enzyme but not in the mouse enzyme
6,6'-[[5-(aminomethyl)-1,3-phenylene]di(ethane-2,1-diyl)]bis(4-methylpyridin-2-amine)
compound interacts with the active site Glu243 and heme propionate D through a series of hydrogen bonds between the aminopyridine functional groups. Comparison with inhibition of mammalian NOS isoforms
6-([(3R,5S)-5-][[[[(6-amino-4-methylpyridin-2-yl)methoxy]methyl]pyrrolidin-3-yl]oxy]methyl)-4-methylpyridin-2-amine
compound impedes the growth of Bacillus subtilis under oxidative stress
6-[5-([4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]oxy)pentyl]-4-methylpyridin-2-amine
binding is stabilized by a 3.2 A H-bond between the pyrrolidine ring and the carbonyl group of tetrahydrobiopterin
N,N'-[[(2S)-3-aminopropane-1,2-diyl]bis(oxymethylene-3,1-phenylene)]di(thiophene-2-carboximidamide)
inhibitor binds by extending outside the active site to interact with a surface adjacent to residue Y357
N1-[6-[2-(6-amino-4-methylpyridin-2-yl)ethyl]pyridin-2-yl]-N1,N2-dimethylethane-1,2-diamine
inhibitor binding distorts the pterin binding site by inducing an alternative rotameric position in residue W329. KS value 18.3 microM
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quinolin-2-amine
among the most potent aminoquinoline inhibitors tested, KS value 0.00125 mM