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1.14.14.47: nitric-oxide synthase (flavodoxin)

This is an abbreviated version!
For detailed information about nitric-oxide synthase (flavodoxin), go to the full flat file.

Word Map on EC 1.14.14.47

Reaction

2 L-arginine + 2 reduced flavodoxin + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 oxidized flavodoxin + 2 H2O

Synonyms

bNOS, GK1676, nitric oxide synthetase, NO synthase, NOS, SANOS, YumC

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.47 nitric-oxide synthase (flavodoxin)

Inhibitors

Inhibitors on EC 1.14.14.47 - nitric-oxide synthase (flavodoxin)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-bromo-7-nitroindazole
-
3-[2,4-di(6-amino-4-methylpyridin-2-yl)ethyl]benzonitrile
inhibitor binds to heme propionate A through a bifurcated H-bond and a pi-pi stacking interaction between the conserved Tyr and aminopyridine group
4-methylquinolin-2-amine
among the most potent aminoquinoline inhibitors tested, KS value 0.00080 mM
6,6'-[(5-amino-1,3-phenylene)di(ethane-2,1-diyl)]bis(4-methylpyridin-2-amine)
compound interacts with the active site Glu243 and heme propionate D through a series of hydrogen bonds between the aminopyridine functional groups. Comparison with inhibition of mammalian NOS isoforms
6,6'-[[(2S,3S)-2-aminobutane-1,3-diyl]bis(oxymethanediyl)]bis(4-methylpyridin-2-amine)
compound impedes the growth of Bacillus subtilis under oxidative stress an is able to displace the tetrahydrobiopterin cofactor in the Bacillus subtilis enzyme but not in the mouse enzyme
6,6'-[[5-(aminomethyl)-1,3-phenylene]di(ethane-2,1-diyl)]bis(4-methylpyridin-2-amine)
compound interacts with the active site Glu243 and heme propionate D through a series of hydrogen bonds between the aminopyridine functional groups. Comparison with inhibition of mammalian NOS isoforms
6-([(3R,5S)-5-][[[[(6-amino-4-methylpyridin-2-yl)methoxy]methyl]pyrrolidin-3-yl]oxy]methyl)-4-methylpyridin-2-amine
compound impedes the growth of Bacillus subtilis under oxidative stress
6-[5-([4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]oxy)pentyl]-4-methylpyridin-2-amine
binding is stabilized by a 3.2 A H-bond between the pyrrolidine ring and the carbonyl group of tetrahydrobiopterin
7-nitroindazole
-
N,N'-[[(2S)-3-aminopropane-1,2-diyl]bis(oxymethylene-3,1-phenylene)]di(thiophene-2-carboximidamide)
inhibitor binds by extending outside the active site to interact with a surface adjacent to residue Y357
N-omega-nitro-L-arginine
-
N1-[6-[2-(6-amino-4-methylpyridin-2-yl)ethyl]pyridin-2-yl]-N1,N2-dimethylethane-1,2-diamine
inhibitor binding distorts the pterin binding site by inducing an alternative rotameric position in residue W329. KS value 18.3 microM
-
Ngamma-nitro-L-arginine
-
competitive
quinolin-2-amine
among the most potent aminoquinoline inhibitors tested, KS value 0.00125 mM