1.14.14.47: nitric-oxide synthase (flavodoxin)
This is an abbreviated version!
For detailed information about nitric-oxide synthase (flavodoxin), go to the full flat file.
Word Map on EC 1.14.14.47
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1.14.14.47
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familia
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latino
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pacientes
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farmworker
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grupos
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condom
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analysis
- 1.14.14.47
-
familia
-
latino
-
pacientes
-
farmworker
-
grupos
-
condom
- analysis
Reaction
2 L-arginine + 2 reduced flavodoxin + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 oxidized flavodoxin + 2 H2O
Synonyms
bNOS, GK1676, nitric oxide synthetase, NO synthase, NOS, SANOS, YumC
ECTree
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Reference on EC 1.14.14.47 - nitric-oxide synthase (flavodoxin)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, Z.; Lawson, R.J.; Buddha, M.R.; Wei, C.; Crane, B.R.; Munro, A.W.; Stuehr, D.J.
Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase
J. Biol. Chem.
282
2196-2202
2007
Bacillus subtilis
Gusarov, I.; Starodubtseva, M.; Wang, Z.Q.; McQuade, L.; Lippard, S.J.; Stuehr, D.J.; Nudler, E.
Bacterial nitric-oxide synthases operate without a dedicated redox partner
J. Biol. Chem.
283
13140-13147
2008
Bacillus anthracis, Bacillus subtilis
Chen, Y.; Rosazza, J.
A bacterial nitric oxide synthase from a Nocardia species
Biochem. Biophys. Res. Commun.
203
1251-1258
1994
Nocardia sp.
Buddha, M.R.; Tao, T.; Parry, R.J.; Crane, B.R.
Regioselective nitration of tryptophan by a complex between bacterial nitric-oxide synthase and tryptophanyl-tRNA synthetase
J. Biol. Chem.
279
49567-49570
2004
Deinococcus radiodurans
Hannibal, L.; Somasundaram, R.; Tejero, J.; Wilson, A.; Stuehr, D.
Influence of heme-thiolate in shaping the catalytic properties of a bacterial nitric-oxide synthase
J. Biol. Chem.
286
39224-39235
2011
Bacillus subtilis
Agapie, T.; Suseno, S.; Woodward, J.; Stoll, S.; Britt, R.; Marletta, M.
NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum
Proc. Natl. Acad. Sci. USA
106
16221-16226
2009
Sorangium cellulosum
Bird, L.; Ren, J.; Zhang, J.; Foxwell, N.; Hawkins, A.; Charles, I.; Stammers, D.
Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus
Structure
10
1687-1696
2002
Staphylococcus aureus (P0A004), Staphylococcus aureus
Pant, K.; Bilwes, A.M.; Adak, S.; Stuehr, D.J.; Crane, B.R.
Structure of a nitric oxide synthase heme protein from Bacillus subtilis
Biochemistry
41
11071-11079
2002
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Santolini, J.; Roman, M.; Stuehr, D.; Mattioli, T.
Resonance Raman study of Bacillus subtilis NO synthase-like protein: Similarities and differences with mammalian NO synthases
Biochemistry
45
1480-1489
2006
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Pant, K.; Crane, B.R.
Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation
Biochemistry
45
2537-2544
2006
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Kabir, M.; Sudhamsu, J.; Crane, B.R.; Yeh, S.R.; Rousseau, D.L.
Substrate-ligand interactions in Geobacillus stearothermophilus nitric oxide synthase
Biochemistry
47
12389-12397
2008
Geobacillus stearothermophilus
Holden, J.K.; Dejam, D.; Lewis, M.C.; Huang, H.; Kang, S.; Jing, Q.; Xue, F.; Silverman, R.B.; Poulos, T.L.
Inhibitor bound crystal structures of bacterial nitric oxide synthase
Biochemistry
54
4075-4082
2015
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Holden, J.K.; Lewis, M.C.; Cinelli, M.A.; Abdullatif, Z.; Pensa, A.V.; Silverman, R.B.; Poulos, T.L.
Targeting bacterial nitric oxide synthase with aminoquinoline-based inhibitors
Biochemistry
55
5587-5594
2016
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Adak, S.; Aulak, K.S.; Stuehr, D.J.
Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis
J. Biol. Chem.
277
16167-16171
2002
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Sudhamsu, J.; Crane, B.R.
Structure and reactivity of a thermostable prokaryotic nitric-oxide synthase that forms a long-lived oxy-heme complex
J. Biol. Chem.
281
9623-9632
2006
Geobacillus kaustophilus (Q5KZC5)
Brunel, A.; Wilson, A.; Henry, L.; Dorlet, P.; Santolini, J.
The proximal hydrogen bond network modulates Bacillus subtilis nitric-oxide synthase electronic and structural properties
J. Biol. Chem.
286
11997-12005
2011
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Holden, J.K.; Lim, N.; Poulos, T.L.
Identification of redox partners and development of a novel chimeric bacterial nitric oxide synthase for structure activity analyses
J. Biol. Chem.
289
29437-29445
2014
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Holden, J.K.; Kang, S.; Hollingsworth, S.A.; Li, H.; Lim, N.; Chen, S.; Huang, H.; Xue, F.; Tang, W.; Silverman, R.B.; Poulos, T.L.
Structure-based design of bacterial nitric oxide synthase inhibitors
J. Med. Chem.
58
994-1004
2015
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Pant, K.; Crane, B.R.
Structure of a loose dimer: an intermediate in nitric oxide synthase assembly
J. Mol. Biol.
352
932-940
2005
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Holden, J.K.; Li, H.; Jing, Q.; Kang, S.; Richo, J.; Silverman, R.B.; Poulos, T.L.
Structural and biological studies on bacterial nitric oxide synthase inhibitors
Proc. Natl. Acad. Sci. USA
110
18127-18131
2013
Bacillus subtilis (O34453), Bacillus subtilis 168 (O34453)
Holden, J.K.; Lim, N.; Poulos, T.L.
Identification of redox partners and development of a novel chimeric bacterial nitric oxide synthase for structure activity analyses
J. Biol. Chem.
289
29437-29445
2014
Bacillus subtilis subsp. subtilis (O05268), Bacillus subtilis subsp. subtilis 168 (O05268)
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