1.3.1.3: DELTA4-3-oxosteroid 5beta-reductase

This is an abbreviated version!
For detailed information about DELTA4-3-oxosteroid 5beta-reductase, go to the full flat file.

Word Map on EC 1.3.1.3

Reaction

17,21-dihydroxy-5beta-pregnane-3,11,20-trione
+
NADP+
=
cortisone
+
NADPH
+
H+

Synonyms

3-oxo-DELTA4-steroid 5beta-reductase, 4,5beta-dihydrocortisone:NADP+ DELTA4-oxidoreductase, 5-beta-reductase, 5beta-POR, 5beta-red, AKR1D1, aldo-keto reductase, aldo-keto reductase 1D1, aldo–keto reductase 1D1, androstenedione 5beta-reductase, cortisone 5beta-reductase, cortisone beta-reductase, DELTA 4-5beta-reductase, DELTA4-3-ketosteroid 5beta-reductase, DELTA4-3-oxosteroid 5beta-reductase, DELTA4-hydrogenase, EC 1.3.1.3, h5beta-red, h5beta-reductase, More, P5betaR, progesterone 5beta-reductase, reductase, cholestenone 5beta.-, reductase, cortisone DELTA4-5beta-, steroid 5beta-reductase, steroid 5beta.-reductase, testosterone 5-beta-reductase, testosterone 5beta-reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.3 DELTA4-3-oxosteroid 5beta-reductase

Storage Stability

Storage Stability on EC 1.3.1.3 - DELTA4-3-oxosteroid 5beta-reductase

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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-10°C, stable for 2-3 days
-
4°C, 72 h, 0.05 M Tris-maleate buffer, pH 7.4-8.4, stable
-
4°C, pH 8, 32 days, 25% loss of activity
-
4°C, rapid loss of activity, 2-mercaptoethanol stabilizes
-