1.5.99.4: nicotine dehydrogenase

This is an abbreviated version!
For detailed information about nicotine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.99.4

Reaction

(S)-nicotine
+
acceptor
+
H2O
=
(S)-6-hydroxynicotine
+
reduced acceptor

Synonyms

6-hydroxy-D-nicotine oxidase, 6-hydroxy-L-nicotine oxidase, D-nicotine oxidase, NctA, NDH, NdhAB, nicotine dehydrogenase, nicotine oxidase, nicotinic acid hydroxylase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.99 With unknown physiological acceptors
                1.5.99.4 nicotine dehydrogenase

Cloned

Cloned on EC 1.5.99.4 - nicotine dehydrogenase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene 6hdno of pAO1, DNA and amino acid sequence determination and analysis, sequence comparisons, genetic organization
gene 6hdno of pAO1, DNA sequence analysis, genetic organization, primer extension analysis, transcriptional analysis, binding and regulatory role of repressor HdnoR, effector protein IR1 is involved, overview
gene nox, DNA and amino acid sequence deteremination and analysis, recombinant expression from a broad-host-range cloning vector in Escherichia coli strain DH5alpha and Pseudomonas putida strain KT2440, the enzyme is exxpressed in both hosts but only active in Pseudomonas putida