1.5.99.4: nicotine dehydrogenase

This is an abbreviated version!
For detailed information about nicotine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.99.4

Reaction

(S)-nicotine
+
acceptor
+
H2O
=
(S)-6-hydroxynicotine
+
reduced acceptor

Synonyms

6-hydroxy-D-nicotine oxidase, 6-hydroxy-L-nicotine oxidase, D-nicotine oxidase, NctA, NDH, NdhAB, nicotine dehydrogenase, nicotine oxidase, nicotinic acid hydroxylase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.99 With unknown physiological acceptors
                1.5.99.4 nicotine dehydrogenase

Reference

Reference on EC 1.5.99.4 - nicotine dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nagel, M.; Koenig, K.; Andreesen, J.R.
Bactopterin as component of eubacterial dehydrogenases involved in hydroxylation reactions initiating the degradation of nicotine, nicotinate, and 2-furancarboxylate
FEMS Microbiol. Lett.
60
323-326
1989
Pseudarthrobacter oxydans
-
Manually annotated by BRENDA team
Schenk, S.; Hoelz, A.; Krauss, B.; Decker, K.
Gene structures and properties of enzymes of the plasmid-encoded nicotine catabolism of Arthrobacter nicotinovorans
J. Mol. Biol.
284
1323-1339
1998
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Grether-Beck, S.; Igloi, G.L.; Pust, S.; Schilz, E.; Decker, K.; Brandsch, R.
Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans
Mol. Microbiol.
13
929-936
1994
Paenarthrobacter nicotinovorans, Paenarthrobacter nicotinovorans (Q93NH4)
Manually annotated by BRENDA team
Decker, K.; Bleeg, H.
Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans
Biochim. Biophys. Acta
105
313-324
1965
Pseudarthrobacter oxydans
Manually annotated by BRENDA team
Freudenberg, W.; Koenig, K.; Andreesen, J.R.
Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase
FEMS Microbiol. Lett.
52
13-18
1988
Pseudarthrobacter oxydans
-
Manually annotated by BRENDA team
Hochstein, L.L.; Dalton, B.P.
The purification and properties of nicotine oxidase
Biochim. Biophys. Acta
139
56-68
1967
Pseudarthrobacter oxydans
Manually annotated by BRENDA team
Williams, D.E.; Ding, X.; Coon, M.J.
Rabbit nasal cytochrome P-450 NMa has high activity as a nicotine oxidase
Biochem. Biophys. Res. Commun.
166
945-952
1990
Oryctolagus cuniculus
Manually annotated by BRENDA team
Nakayama, H.; Nakashima, T.; Kurogochi, Y.
Heterogeneity of hepatic nicotine oxidase
Biochim. Biophys. Acta
715
254-257
1982
Rattus norvegicus
Manually annotated by BRENDA team
Jones, M.V.
Cytochrome c linked nicotinic acid hydroxylase in Pseudomonas ovalis chester
FEBS Lett.
32
321-324
1973
Pseudomonas putida, Pseudomonas putida Chester
Manually annotated by BRENDA team
Behrman, E.J.; Stanier, R.Y.
The bacterial oxidation of nicotinic acid
J. Biol. Chem.
228
923-945
1957
Pseudomonas fluorescens, Pseudomonas fluorescens N-9
Manually annotated by BRENDA team
Igloi, G.L.; Brandsch, R.
Sequence of the 165-kilobase catabolic plasmid pAO1 from Arthrobacter nicotinovorans and identification of a pAO1-dependent nicotine uptake system
J. Bacteriol.
185
1976-1986
2003
Paenarthrobacter nicotinovorans (Q59127), Paenarthrobacter nicotinovorans (Q59128), Paenarthrobacter nicotinovorans (Q59129)
Manually annotated by BRENDA team
Sandu, C.; Chiribau, C.B.; Brandsch, R.
Characterization of HdnoR, the transcriptional repressor of the 6-hydroxy-D-nicotine oxidase gene of Arthrobacter nicotinovorans pAO1, and its DNA-binding activity in response to L- and D-nicotine Derivatives
J. Biol. Chem.
278
51307-51315
2003
Paenarthrobacter nicotinovorans (Q59127), Paenarthrobacter nicotinovorans (Q59128), Paenarthrobacter nicotinovorans (Q59129)
Manually annotated by BRENDA team
Sachelaru, P.; Schiltz, E.; Brandsch, R.
A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans
Appl. Environ. Microbiol.
72
5126-5131
2006
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Ganas, P.; Sachelaru, P.; Mihasan, M.; Igloi, G.L.; Brandsch, R.
Two closely related pathways of nicotine catabolism in Arthrobacter nicotinovorans and Nocardioides sp. strain JS614
Arch. Microbiol.
189
511-517
2008
Nocardioides sp., Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Qiu, J.; Ma, Y.; Zhang, J.; Wen, Y.; Liu, W.
Cloning of a novel nicotine oxidase gene from Pseudomonas sp. strain HZN6 whose product nonenantioselectively degrades nicotine to pseudooxynicotine
Appl. Environ. Microbiol.
79
2164-2171
2013
no activity in Escherichia coli strain DH5alpha, no activity in Pseudomonas putida strain KT2440, Pseudomonas sp. (M4T5L3), Pseudomonas sp. HZN6 (M4T5L3)
Manually annotated by BRENDA team
Li, H.; Xie, K.; Yu, W.; Hu, L.; Huang, H.; Xie, H.; Wang, S.
Nicotine dehydrogenase complexed with 6-hydroxypseudooxynicotine oxidase involved in the hybrid nicotine-degrading pathway in Agrobacterium tumefaciens S33
Appl. Environ. Microbiol.
82
1745-1755
2016
Agrobacterium tumefaciens, Agrobacterium tumefaciens S33
Manually annotated by BRENDA team
Qiu, J.; Li, N.; Lu, Z.; Yang, Y.; Ma, Y.; Niu, L.; He, J.; Liu, W.
Conversion of nornicotine to 6-hydroxy-nornicotine and 6-hydroxy-myosmine by Shinella sp. strain HZN7
Appl. Microbiol. Biotechnol.
100
10019-10029
2016
Shinella sp. HZN7 (A0A0Y0MN26)
Manually annotated by BRENDA team