1.8.4.13: L-methionine (S)-S-oxide reductase
This is an abbreviated version!
For detailed information about L-methionine (S)-S-oxide reductase, go to the full flat file.
Reaction
Synonyms
EC 1.8.4.5, free-methionine-R-sulfoxide reductase, fRMsr, fSMsr, methionine sulfoxide reductase
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 1.8.4.13 - L-methionine (S)-S-oxide reductase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
L-(-)-methionine S-oxide + NADPH
L-methionine + NADP+ + H2O
-
the enzyme is specific for the L-(-)-stereoisomer
-
-
ir
L-methionine (S)-sulfoxide + NADPH + H+
L-methionine + NADP+ + H2O
-
membrane-bound enzyme form Mem-R,S-Msr
-
-
?
sulindac + NADPH
sulindac sulfide + NADP+ + H2O
-
activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr
activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity
-
?
?
-
-
the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions
-
-
?
additional information
?
-
-
methionine sulfoxide reduction pathway, overview
-
-
?
additional information
?
-
-
the enzyme might act in vivo on the free methionine sulfoxide substrate or on protein-bound methionine sulfoxide residues
-
-
?
additional information
?
-
-
the enzyme might act in vivo on the free methionine sulfoxide substrate or on protein-bound methionine sulfoxide residues
-
-
?