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IUBMB CommentsA hemoprotein. The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin. The enzyme oxidizes a bound Mn2+ ion to Mn3+ in the presence of hydrogen peroxide. The product, Mn3+, is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn2+ and insoluble Mn4+ . The complexed Mn3+ ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates . It is inactive with veratryl alcohol or nonphenolic substrates.
Synonyms
manganese peroxidase, manganese-dependent peroxidase, lemnp2, il-mnp1, mnp-gy, hybrid mn-peroxidase, short mnp, peroxidase-m2, mnp-pgy, mrmnp1,
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manganese peroxidase 2
UniProt
manganese-dependent peroxidase
Mn-dependent (NADH-oxidizing) peroxidase
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Mn2+: hydrogen peroxide oxidoreductase
Mn2+:hydrogen peroxide oxidoreductase
MnP-GY
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isoenzyme synthesized in glucose-yeast extract medium has VTCATGQTTANE at the N-terminus
MnP-PGY
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isoenzyme synthesized in peptone-glucose-yeast extract medium has ATCADGRTTANA at the N-terminus
multifunctional manganese peroxidase
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peroxidase, manganese
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short manganese peroxidase
CmMnP
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extralong PMnP
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hybrid Mn-peroxidase
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hybrid Mn-peroxidase
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Il-MnP1
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Il-MnP6
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LeMnP2
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long PMnP
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manganese peroxidase
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manganese peroxidase
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manganese peroxidase
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manganese peroxidase
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manganese peroxidase
Inocybe longicystis
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manganese peroxidase
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manganese peroxidase
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manganese peroxidase
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manganese peroxidase
Lepiota naucina
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manganese peroxidase
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manganese peroxidase
Leptonia lazunila
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manganese peroxidase
Lyophyllum subglobisporium
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manganese peroxidase
Lyophyllum subglobisporium ECN 100606
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manganese peroxidase
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manganese peroxidase
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manganese peroxidase
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manganese peroxidase
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manganese peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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manganese-dependent peroxidase
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Mn2+: hydrogen peroxide oxidoreductase
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Mn2+: hydrogen peroxide oxidoreductase
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Mn2+: hydrogen peroxide oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:H2O2 oxidoreductase
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Mn2+:hydrogen peroxide oxidoreductase
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Mn2+:hydrogen peroxide oxidoreductase
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Mn2+:hydrogen peroxide oxidoreductase
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MnP
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MnP II
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MnP-BBP6
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mnp1
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MnP10
gene name, UniProt
MnP10
gene name, UniProt
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MnP117436
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MnP12
gene name, UniProt
MnP12
gene name, UniProt
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MnP157986
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MnP2
gene name, UniProt
MnP2
gene name, UniProt
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MnP3
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MnP50297
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MnP6
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Moror_3885
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MrMnP1
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Nf b19 MNP2
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rMnP3-BBP6
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short manganese peroxidase
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short manganese peroxidase
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short manganese peroxidase
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short MnP
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
ping-pong mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
kinetic mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
shows properties of a peroxidase and an oxidase
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
the proton-coupled electron transfer (PCET) process dominates the catalytic circle of MnP and the transformation of Mn3+, density functional theory (DFT) calculations, overview. During the reaction of H2O2 in the active MnP system, a typical signal of DMPO-Mn3+ is observed, indicating that MnP catalyzes Mn2+ to Mn3+
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
ping-pong mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
shows properties of a peroxidase and an oxidase
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
the proton-coupled electron transfer (PCET) process dominates the catalytic circle of MnP and the transformation of Mn3+, density functional theory (DFT) calculations, overview. During the reaction of H2O2 in the active MnP system, a typical signal of DMPO-Mn3+ is observed, indicating that MnP catalyzes Mn2+ to Mn3+
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
shows properties of a peroxidase and an oxidase
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
ping-pong mechanism
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
the proton-coupled electron transfer (PCET) process dominates the catalytic circle of MnP and the transformation of Mn3+, density functional theory (DFT) calculations, overview. During the reaction of H2O2 in the active MnP system, a typical signal of DMPO-Mn3+ is observed, indicating that MnP catalyzes Mn2+ to Mn3+
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
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1,4-benzenediol + 2 H+ + H2O2
? + 2 H2O
2 KBr + 2 H+ + H2O2
Br2 + 2 H2O + 2 K+
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?
2 KI + 2 H+ + H2O2
I2 + 2 H2O + 2 K+
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?
2 Mn(II) + 2 H+ + H2O2
2 Mn(III) + 2 H2O
2 Mn2+ + 2 H+ + H2O2
2 Mn3+ + 2 H2O
2 Mn2+ + H2O2 + aflatoxin B1
2 Mn3+ + aflatoxin B1-8,9-dihydrodiol
2 veratryl alcohol + H2O2
2 veratraldehyde + H2O
2,2'-azino-bis(3-ethyl-benzothiazoline-6-sulfonic acid) + H2O2
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2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulphonate + H2O2
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reaction with and without Mn2+
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?
2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) + 2 H+ + H2O2
oxidized 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) + 2 H2O
2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonate) + H2O2
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2,2'-azino-bis(3-ethylbenzthiazole-6-sulfonic acid) + H2O2
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2,2'-azino-bis(3-ethylbenzthiazole-6-sulfonic acid) + H2O2 + H+
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2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) + Mn2+ + ?
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2,2'-azinobis(3-ethylbenzthiazoline)-6-sulfonic acid + H2O2
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2,2'-azinobis(3-ethylbenzthiazoline)-6-sulfonic acid + H2O2 + Mn2+
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?
2,2-azino-di-3-ethylbenzothiazoline-6-sulfonate + H+ + H2O2
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r
2,2-azino-di-3-ethylbenzothiazoline-6-sulfonate + Mn2+ + H2O2
?
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r
2,4,6-trichlorophenol + H2O2
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2,6-dimethoxyphenol + 2 H+ + H2O2
coerulignone + 2 H2O
MnP activity is determined spectrophotometrically by measuring the oxidation of 2,6-dimethoxyphenol to coerulignone (epsilon = 49.6 mM/cm) in 50 mM malonate buffer (pH 4.5) containing 1.0 mM MnSO4, 1.0 mM 2,6-dimethoxyphenol, and 0.2 mM H2O2 at 469 nm, 37°C
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?
2,6-dimethoxyphenol + 2 H+ + H2O2
oxidized 2,6-dimethoxyphenol + 2 H2O
2,6-dimethoxyphenol + H+ + H2O2
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2,6-dimethoxyphenol + H2O2
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2,6-dimethoxyphenol + H2O2
coerulignone + H2O
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r
2,6-dimethoxyphenol + H2O2 + H+
coerulignone + H2O
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r
2,6-dimethoxyphenol + H2O2 + Mn2+
?
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2,6-dimethoxyphenol + Mn2+ + ?
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2,6-dimethoxyphenol + Mn2+ + H2O2
coerulignone + Mn3+ + H2O
2-bromonaphthalene + ?
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oxidation in presence of Tween 80
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?
4-(4-hydroxy-3-methoxy-phenyl)-2-butanone + H2O2
4-[6,2'-dihydroxy-5,3'-dimethoxy-5'-(3-oxo-butyl)-biphenyl]-butan-2-one + 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one + 4-[6,2'-dihydroxy-5,3'-dimethoxy-5'-(3-oxo-butyl)-biphenyl]-3-buten-2-one + 3-(3-oxo-butyl)-hexa-2,4-dienedioic acid-1-methyl ester
4-aminophenol + H2O2
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reaction in presence of Mn2+
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?
4-methoxyphenol + H2O2
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reaction in
1.11.1.13 manganese peroxidase
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