2.4.1.38: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
This is an abbreviated version!
For detailed information about beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.38
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2.4.1.38
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galts
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galactosylate
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synthesis
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alpha-lactalbumin
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p34cdc2-related
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beta4galts
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drug development
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pharmacology
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medicine
- 2.4.1.38
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galts
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galactosylate
- synthesis
- alpha-lactalbumin
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p34cdc2-related
- beta4galts
- drug development
- pharmacology
- medicine
Reaction
Synonyms
(alpha4Gal-T1), 4betaGalT, acetyllactosamine synthetase, alpha-1,4-galactosyltransferase I, B4GALT1, beta 1, 4-GalT-I, beta 1,4-galactosyltransferase 1, beta 1,4-GalT-I, beta 1,4GalT V, beta(1,4)-galactosyltransferase, beta(1,4)-GalT, beta(1,4)-GT, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase IV, beta-1,4-galactosyltransferase-I, beta-1,4-GalT, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta-1,4-GalT5, beta-1,4-GalT6, beta-1,4-GalT7, beta-1,4-GT-IV, beta-N-acetyl-beta1-4-galactosyltransferase, beta-N-acetylglucosaminide beta1-4-galactosyltransferase, beta1,4-Gal-transferase T1, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase 1, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase II, beta1,4-galactosyltransferase V, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase-I, beta1,4-galactosyltransferase1, beta1,4-GalT1, beta1,4-GalT7, beta1,4-GT, beta1,4-GT 1, beta1,4GalT II, beta1,4GT1, beta1-4-galactosyltransferase, beta1-4GalT, beta1-4GalT1, beta4 Gal-transferase, beta4-GalT-I, beta4-GalT-II, beta4-GalT-III, beta4-GalT-IV, beta4-GalT-V, beta4Gal-T1, beta4GalT, beta4GalT-II, beta4GalT1, beta4GalT7, betaGalT, betaGalT-1, betaGALT1, betaGT, EC 2.4.1.98, Gal-T, Gal-T1, galactosyltransferase 7, galactosyltransferase, uridine diphosphogalactose-acetylglucosamine, GalNAcT2, GALT, GalT I, GalT V, GalT1, GalTase, GalTI, glycoprotein 4-beta-galactosyl-transferase, glycoprotein beta-galactosyltransferase, HP0826, lactosamine synthase, lactosamine synthetase, lactose synthetase A protein, LgtB, LgtB-A, LgtB-B, LgtH, More, N-acetylglucosamine beta1,4 galactosyltransferase, N-acetyllactosamine synthetase, NAL synthetase, thyroid galactosyltransferase, thyroid glycoprotein beta-galactosyltransferase, UDP-beta-1,4-galactosyltransferase, UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 1, UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase, UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase, UDP-galactose-acetylglucosamine galactosyltransferase, UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase, UDP-galactose-N-acetylglucosamine galactosyltransferase, UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase 2, UDPgalactose-glycoprotein galactosyltransferase, UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase, UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase, UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase, uridine diphosphogalactose-acetylglucosamine galactosyltransferase, uridine diphosphogalactose-glycoprotein galactosyltransferase
ECTree
2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferaseAdvanced search results
results (
results (KM Value
KM Value on EC 2.4.1.38 - beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
6.28
galactosyl-beta-1,4-N-acetylglucosaminyl-beta-1,2-mannosyl-alpha-1,6-(N-acetylglucosaminyl-beta-1,2-mannosyl-alpha-1,3-)mannosyl-beta-1,4-N-acetylglucosaminyl-beta-1,4-(fucosyl-alpha-1,6-)N-acetylglucosaminyl-asparagine
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0.43
N-acetylglucosaminyl-beta-1,2-mannosyl-alpha-1,6-(galactosyl-beta-1,4-N-acetylglucosaminyl-beta-1,2-mannosyl-alpha-1,3-)mannosyl-beta-1,4-N-acetylglucosaminyl-beta-1,4-(fucosyl-alpha-1,6-)N-acetylglucosaminyl-asparagine
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-
0.13
N-acetylglucosaminyl-beta-1,2-mannosyl-alpha-1,6-(N-acetylglucosaminyl-beta-1,2-mannosyl-alpha-1,3-)mannosyl-beta-1,4-N-acetylglucosaminyl-beta-1,4-(fucosyl-alpha-1,6-)N-acetylglucosaminyl-asparagine
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3.4
N-acetylglucosaminyl-beta-1,3-(galactosyl-beta-1,4-N-acetylglucosaminyl-beta-1,6-)galactose
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1.5
N-acetylglucosaminyl-beta-1,6-galactose
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N-acetylglucosaminyl-beta-1,3-(N-acetylglucosaminyl-beta-1,6-)galactose
4
UDP-glucuronic acid
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Km above 4 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
10
UDP-N-acetyl-alpha-D-glucosamine
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Km above 10 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.16
UDP-xylose
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purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.16
4-methylumbelliferyl beta-D-xylopyranoside
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purified beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.27
4-methylumbelliferyl beta-D-xylopyranoside
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purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.35
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme H195R, at pH 7.0 and 37°C
0.35
4-methylumbelliferyl-beta-D-xylopyranoside
recombinant wild type enzyme, at pH 7.0 and 37°C
0.44
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R226A, at pH 7.0 and 37°C
0.46
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R226K, at pH 7.0 and 37°C
0.54
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R270K, at pH 7.0 and 37°C
0.55
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme H195Q, at pH 7.0 and 37°C
0.59
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme Y199F, at pH 7.0 and 37°C
0.6
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme R270A, at pH 7.0 and 37°C
0.64
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme H195A, at pH 7.0 and 37°C
1.06
4-methylumbelliferyl-beta-D-xylopyranoside
mutant enzyme Y196F, at pH 7.0 and 37°C
0.85
4-nitrophenyl beta-D-xylopyranoside
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purified beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
1.27
4-nitrophenyl beta-D-xylopyranoside
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purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.0007
N-acetylglucosamine
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cosubstrate: UDP-galactose, in presence of alpha-lactalbumin, mutant enzyme R228K
0.0013
N-acetylglucosamine
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cosubstrate: UDP-glucose, in presence of alpha-lactalbumin, mutant enzyme R228K
0.0025
N-acetylglucosamine
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cosubstrate: UDP-glucose, in presence of alpha-lactalbumin, wild-type enzyme
0.009
N-acetylglucosamine
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cosubstrate: UDP-glucose, without alpha-lactalbumin, mutant enzyme R228K
0.011
N-acetylglucosamine
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cosubstrate: UDP-galactose, without alpha-lactalbumin, mutant enzyme R228K
0.011
N-acetylglucosamine
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cosubstrate: UDP-galactose, without alpha-lactalbumin, wild-type enzyme
0.074
N-acetylglucosamine
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cosubstrate: UDP-glucose, without alpha-lactalbumin, wild-type enzyme
0.22
UDP-alpha-D-galactose
recombinant wild type enzyme, at pH 7.0 and 37°C
0.0105
UDP-galactose
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cosubstrate: N-acetylglucosamine, in presence of alpha-lactalbumin, mutant enzyme R228K
0.087
UDP-galactose
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cosubstrate: N-acetylglucosamine, without alpha-lactalbumin, mutant enzyme R228K
0.093
UDP-galactose
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cosubstrate: N-acetylglucosamine, without alpha-lactalbumin, wild-type enzyme
0.23
UDP-galactose
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purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.31
UDP-galactose
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purified beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.031
UDP-glucose
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cosubstrate: N-acetylglucosamine, in presence of alpha-lactalbumin, wild-type enzyme
0.044
UDP-glucose
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cosubstrate: N-acetylglucosamine, in presence of alpha-lactalbumin, mutant enzyme R228K
0.091
UDP-glucose
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cosubstrate: N-acetylglucosamine, without alpha-lactalbumin, mutant enzyme R228K
0.148
UDP-glucose
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cosubstrate: N-acetylglucosamine, without alpha-lactalbumin, wild-type enzyme
0.28
UDP-glucose
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purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.2
UDPgalactose
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reaction with glucose, wild-type enzyme and N-deglycosylated recombinant enzyme
additional information
additional information
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effects of cationic polypeptides
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additional information
additional information
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Km-value for ovalbumin for the N-deglycosylated recombinant enzyme is 6 mg/ml, and 15 mg/ml for th recombinant enzyme
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additional information
additional information
kinetics, implications of the oligosaccharide structures on the kinetic parameters, overview
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additional information
additional information
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kinetics, mutant enzyme, overview
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