2.7.1.36: mevalonate kinase

This is an abbreviated version!
For detailed information about mevalonate kinase, go to the full flat file.

Word Map on EC 2.7.1.36

2.7.1.36

fever

autoinflammatory

cholesterol

isoprenoids

mediterranean

aciduria

hereditary

receptor-associated

hyperimmunoglobulinemia

vinyl

ketone

cryopyrin-associated

phosphomevalonate

febrile

igd

isopentenyl

monogenic

farnesyl

tnfrsf1a

isoprene

hyper-igd

anakinra

rash

lymphadenopathy

hmg-coa

inflammasome

geranylgeranylation

amyloidosis

aphthous

porokeratosis

arthralgia

non-sterol

pyoderma

nod2

papa

autoinflammation

gangrenosum

canakinumab

adenitis

pstpip1

hyperimmunoglobulin

medicine

hepatosplenomegaly

cholesterogenesis

etanercept

cryopyrin

synthesis

diagnostics

Reaction

Synonyms

ATP: mevalonate 5-phosphotransferase, ATP:mevalonate 5-phosphotransferase, GbMVK, kinase, mevalonate (phosphorylating), mevalonate 5-phosphotransferase, mevalonate phosphokinase, mevalonic acid kinase, mevalonic kinase, MmMK, MVA kinase, MVK, SSO0383, TcMVK, TeMVK

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.36 mevalonate kinase

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Results	in table
10	Activating Compound
7985	AA Sequence
14	Application
1	CAS Registry Number
34	Cloned(Commentary)
9	Cofactor
10	Crystallization (Commentary)
2073	Disease/ Diagnostics
2	Expression
22	General Information
3	General Stability
9	IC50 Value
106	Inhibitors
2	kcat/KM [mM/s]
48	Ki Value [mM]
160	KM Value [mM]
16	Localization
82	Metals/Ions
42	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
120	Organism
9	Pathway
19	PDB ID
15	pH Optimum
9	pH Range
2	pH Stability
6	pI Value
74	Protein Variants
38	Purification (Commentary)
5	Reaction
1	Reaction Type
119	Reference
84	Source Tissue
22	Specific Activity [micromol/min/mg]
5	Storage Stability
178	Substrates and Products (Substrate)
36	Subunits
34	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
4	Temperature Range [°C]
12	Temperature Stability [°C]
13	Turnover Number [1/s]

KI Value

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KI Value on EC 2.7.1.36 - mevalonate kinase

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0.02

3,3-dimethylallyl diphosphate

Homo sapiens

pH 7.0, 25°C, recombinant mevalonate kinase

641447

2.7

ADP

Enterococcus faecalis

pH 10, 37°C

663334

0.083

dolichol phosphate

Homo sapiens

pH 7.0, 25°C, recombinant mevalonate kinase

641447

0.072

farnesol

Homo sapiens

pH 7.0, 25°C, recombinant mevalonate kinase

641447

0.000034 - 0.046

farnesyl diphosphate

22 entries

0.000029 - 0.045

farnesyl thiodiphosphate

3 entries

0.00055 - 0.116

geranyl diphosphate

8 entries

0.00093 - 0.115

geranylgeranyl diphosphate

6 entries

0.016

isopentenyl diphosphate

Homo sapiens

pH 7.0, 25°C, recombinant mevalonate kinase

641447

0.0036 - 0.016

phytyl diphosphate

4 entries