1.13.11.52: indoleamine 2,3-dioxygenase

This is an abbreviated version!
For detailed information about indoleamine 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.52

Reaction

D-tryptophan
+
O2
=
N-formyl-D-kynurenine

Synonyms

31854, BRAFLDRAFT_126354, CG5163, EC 1.11.1.4, EC 1.13.1.12, hIDO, hIDO1, hTDO, IDO, IDO-1, IDO-2, IDO1, IDO2, INDO, INDOL1, indolamine 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine 2, 3-dioxygenase, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein, indoleamine-2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, L-tryptophan 2,3-dioxygenase, L-tryptophan pyrrolase, mIDO, oxygenase, tryptophan 2,3-di-, proto-IDO, proto-indoleamine 2,3-dioxygenase, superoxygenase, TDO, TDO2, TioF, TO, TRPO, Tryptamin 2,3-dioxygenase, tryptamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, tryptophan dioxygenase, tryptophan oxygenase, tryptophan peroxidase, tryptophan pyrrolase, tryptophan-2,3-dioxygenase, tryptophanase, v1g244579, Vermilion protein

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.52 indoleamine 2,3-dioxygenase

Activating Compound

Activating Compound on EC 1.13.11.52 - indoleamine 2,3-dioxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(1H-indol-3-yl)ethanol
-
effector
3-indoleethanol
-
1 mM, enhances activity by 87%
4-Hydroxypyrazole
-
below 0.1 mM, activation
alpha-interferon
-
alpha-methyl-DL-tryptophan
-
can activate the enzyme when lower concentrations of L-Trp are used
ascorbate
-
promotes IDO peroxidase turnover by reducing Compound II
ascorbic acid
bacterial lipopolysaccharide
-
-
-
beta-interferon
-
induces IDO expression in monocytes
-
cortisone
-
subcutaneously
Cys
-
can reduce the inactive ferric form of the enzyme to the active ferrous form
cytochrome b5
-
D-tryptophan
-
2g subcutaneously
diethyldithiocarbamate
-
inhibits superoxide dismutase
DTT
-
can reduce the inactive ferric form of the enzyme to the active ferrous form
ethylhydroperoxide
-
can reduce the inactive ferric form of the enzyme to the active ferrous form
gamma-interferon
-
GSH
-
can reduce the inactive ferric form of the enzyme to the active ferrous form
hematine
-
-
hydrogen peroxide
-
activates the peroxidase function of IDO to induce protein oxidation and inhibit dioxygenase activity
hyperbaric oxygen
-
hyperoxia
-
induces IDO expression in the lung
-
Inosine
-
0.1 mM, increases activity 5fold
L-ascorbate
required
L-tryptophan
-
2g subcutaneously
lipopolysaccharide
methylene blue
methylhydroperoxide
-
can reduce the inactive ferric form of the enzyme to the active ferrous form
NADPH-cytochrome P450 reductase
-
-
paraquat
-
induces IDO expression in the lung
superoxide
-
the enzyme is inactive unless superoxide anion is present, the native ferric form of the enzyme binds to the superoxide anion to form the oxygenated enzyme
tumor-necrosis-factor-alpha
-
costimulation with gamma-interferon
-
additional information
-