1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase

This is an abbreviated version!
For detailed information about hypoxia-inducible factor-asparagine dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.30

Reaction

hypoxia-inducible factor-L-asparagine
+
2-oxoglutarate
+
O2
=
hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine
+
succinate
+
CO2

Synonyms

asparaginyl hydroxylase, asparaginyl-hydroxylase, factor inhibiting HIF, factor inhibiting HIF-1, factor inhibiting hypoxia inducible factor-1alpha, factor-inhibiting HIF, factor-inhibiting hypoxia-inducible factor, FIH, FIH hydroxylase, HIF asparagine hydroxylase, HIF asparaginyl hydroxylase, HIF hydroxylase, hypoxia-inducible factor asparagine hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.30 hypoxia-inducible factor-asparagine dioxygenase

Engineering

Engineering on EC 1.14.11.30 - hypoxia-inducible factor-asparagine dioxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D201A
inactive
D201E
the mutant shows greatly impaired activity compared to the wild type enzyme
D201G
the mutant shows reduced activity compared to the wild type enzyme
additional information
-
FIH silencing by siRNA