1.14.14.83: geraniol 8-hydroxylase
This is an abbreviated version!
For detailed information about geraniol 8-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.83
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1.14.14.83
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roseus
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catharanthus
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indole
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monoterpenoids
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iridoids
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strictosidine
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ajmalicine
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nadph-cytochrome
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vinblastine
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terpenoid
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co-overexpression
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periwinkle
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vincristine
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croton
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acuminata
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synthesis
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methyljasmonate
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vinca
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camptotheca
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drug development
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pharmacology
- 1.14.14.83
- roseus
-
catharanthus
- indole
-
monoterpenoids
-
iridoids
- strictosidine
- ajmalicine
-
nadph-cytochrome
- vinblastine
-
terpenoid
-
co-overexpression
- periwinkle
- vincristine
-
croton
- acuminata
- synthesis
-
methyljasmonate
- vinca
-
camptotheca
- drug development
- pharmacology
Reaction
Synonyms
10-hydroxygeraniol oxidoreductase, CPR I, Cr10HGO, CYP76B10, CYP76B6, CYP76B6 protein, CYP76F45, EC 1.14.13.152, G10H, G8H, geraniol 10-hydroxylase, geraniol-10-hydroxylase, monoterpene hydroxylase, PgCYP76C9, PgG10H
ECTree
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Application
Application on EC 1.14.14.83 - geraniol 8-hydroxylase
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drug development
co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila
pharmacology
co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila
synthesis
artemisinic acid can be used as a promising elicitor, especially for the production of therapeutically important indole alkaloids
synthesis
introduction of genes encoding strictosidine synthase (STR) and geraniol 8-hydroxylase (G10H), into Ophiorrhiza pumila hairy roots. Overexpression of individual G10H significantly improves camptothecin prdouction. Cooverexpression of G10H and STR genes causes a 56% increase on the yields of camptothecin. Camptothecin extracted from different lines shows similar anti-tumor activity