1.14.14.83: geraniol 8-hydroxylase
This is an abbreviated version!
For detailed information about geraniol 8-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.83
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1.14.14.83
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roseus
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catharanthus
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indole
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monoterpenoids
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iridoids
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strictosidine
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ajmalicine
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nadph-cytochrome
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vinblastine
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terpenoid
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co-overexpression
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periwinkle
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vincristine
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croton
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acuminata
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synthesis
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methyljasmonate
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vinca
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camptotheca
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drug development
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pharmacology
- 1.14.14.83
- roseus
-
catharanthus
- indole
-
monoterpenoids
-
iridoids
- strictosidine
- ajmalicine
-
nadph-cytochrome
- vinblastine
-
terpenoid
-
co-overexpression
- periwinkle
- vincristine
-
croton
- acuminata
- synthesis
-
methyljasmonate
- vinca
-
camptotheca
- drug development
- pharmacology
Reaction
Synonyms
10-hydroxygeraniol oxidoreductase, CPR I, Cr10HGO, CYP76B10, CYP76B6, CYP76B6 protein, CYP76F45, EC 1.14.13.152, G10H, G8H, geraniol 10-hydroxylase, geraniol-10-hydroxylase, monoterpene hydroxylase, PgCYP76C9, PgG10H
ECTree
1.14.14.83 geraniol 8-hydroxylaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.14.14.83 - geraniol 8-hydroxylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
farnesol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyfarnesol + [oxidized NADPH-hemoprotein reductase] + H2O
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
16-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
-
?
nerol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
(R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
GC-MS product analysis
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?
(R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
GC-MS product analysis
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?
cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
GC-MS product analysis
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?
cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
GC-MS product analysis
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?
farnesol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyfarnesol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
farnesol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyfarnesol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
GC-MS product analysis
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?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
GC-MS product analysis
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?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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development and validation of an HPLC detection method for quantification of geraniol and 10-hydroxygeraniol, with separation of geraniol and nerol, overview
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-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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mass spectrometrical product analysis
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?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
-
?
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
16-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
16-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
nerol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
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cis-isomer of geraniol
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?
nerol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
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cis-isomer of geraniol
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-
?
additional information
?
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CrG10H also catalyzed 3'-hydroxylation of the flavanone naringenin to form eriodictyol, a reaction of the flavonoid 3'-hydroxylase. Analysis of the enzyme reactions of the recombinant enzyme with naringenin, apigenin, kaempferol, pcoumaric acid, and ferulic acid, mass spectrometric product analysis, overview
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-
?
additional information
?
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CrG10H also catalyzed 3'-hydroxylation of the flavanone naringenin to form eriodictyol, a reaction of the flavonoid 3'-hydroxylase. Analysis of the enzyme reactions of the recombinant enzyme with naringenin, apigenin, kaempferol, pcoumaric acid, and ferulic acid, mass spectrometric product analysis, overview
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?
additional information
?
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enzyme is a specialized multifunctional enzyme catalyzing two sequential oxidation steps leading to the formation of 8-oxogeraniol from geraniol. The first step, geraniol hydroxylation, is very efficient and fast enough to outcompete geraniol conjugation in plant tissues
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?
additional information
?
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enzyme is a specialized multifunctional enzyme catalyzing two sequential oxidation steps leading to the formation of 8-oxogeraniol from geraniol. The first step, geraniol hydroxylation, is very efficient and fast enough to outcompete geraniol conjugation in plant tissues
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-
?
additional information
?
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CYP76B10 is involved in production of swertiamarin
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-
?
additional information
?
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CYP76B10 is involved in production of swertiamarin
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-
?
